M
Munira Grainger
Researcher at Francis Crick Institute
Publications - 8
Citations - 723
Munira Grainger is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Plasmodium falciparum & Protein kinase A. The author has an hindex of 6, co-authored 8 publications receiving 661 citations.
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Journal ArticleDOI
Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle
Karine G. Le Roch,Jeffrey R. Johnson,Laurence Florens,Yingyao Zhou,Andrey Santrosyan,Munira Grainger,S. Frank Yan,Kim C. Williamson,Anthony A. Holder,Daniel J. Carucci,John R. Yates,Elizabeth A. Winzeler +11 more
TL;DR: Potentially post-transcriptionally regulated genes are identified, and families of functionally related genes were observed to share similar patterns of mRNA and protein accumulation.
Journal ArticleDOI
Formation of the food vacuole in Plasmodium falciparum: A potential role for the 19 kDa fragment of merozoite surface protein 1 (MSP119)
Anton R. Dluzewski,Irene T. Ling,John M. Hopkins,Munira Grainger,Gabriele Margos,Graham H. Mitchell,Anthony A. Holder,L. H. Bannister +7 more
TL;DR: This behavior indicates that MSP119 does not simply follow a classical lysosome-like clearance pathway, instead, it may play a significant role in the biogenesis and function of the food vacuole throughout the intra-erythrocytic phase.
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Extensive differential protein phosphorylation as intraerythrocytic Plasmodium falciparum schizonts develop into extracellular invasive merozoites
Edwin Lasonder,Judith L. Green,Munira Grainger,Gordon Langsley,Gordon Langsley,Anthony A. Holder +5 more
TL;DR: It is proposed that alterations in the phosphoproteome and ubiquitinome reflect a starvation‐induced translational arrest as intracellular schizonts transform into extracellular merozoites.
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Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development
Judith L. Green,Robert W. Moon,David Whalley,Paul W. Bowyer,Claire Wallace,Ankit K. Rochani,Rishi Kumar Nageshan,Steven Howell,Munira Grainger,Hayley M. Jones,Keith H. Ansell,Timothy M. Chapman,Debra L. Taylor,Simon A. Osborne,David A. Baker,Utpal Tatu,Anthony A. Holder +16 more
TL;DR: Findings suggest that CDPK1 may not be a suitable target for further inhibitor development and that the primary mechanism through which the imidazopyridazines kill parasites is by inhibition of PKG or HSP90.
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A reference genome and methylome for the Plasmodium knowlesi A1-H.1 line
Ernest Diez Benavente,Paola Florez de Sessions,Robert W. Moon,Munira Grainger,Anthony A. Holder,Michael J. Blackman,Cally Roper,Chris Drakeley,Arnab Pain,Colin J. Sutherland,Martin L. Hibberd,Susana Campino,Taane G. Clark +12 more
TL;DR: A reference genome is assembled for the PkA1-H.1 line of P. knowlesi, a common parasite of macaques, which has improved genome coverage and a novel description of methylation sites, and will enhance the capabilities of the in vitro model to improve the understanding of the parasite's infection in humans.