S
Sagiv Shifman
Researcher at Hebrew University of Jerusalem
Publications - 83
Citations - 5842
Sagiv Shifman is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 31, co-authored 80 publications receiving 5458 citations. Previous affiliations of Sagiv Shifman include University of Oxford & Wellcome Trust Centre for Human Genetics.
Papers
More filters
Journal ArticleDOI
Identification of loci associated with schizophrenia by genome-wide association and follow-up
Michael Conlon O'Donovan,Nicholas John Craddock,Nadine Norton,Hywel Williams,T. Peirce,Valentina Moskvina,Ivan Nikolov,Marian L. Hamshere,Liam S. Carroll,Lyudmila Georgieva,Sarah Dwyer,Peter Holmans,Jonathan Marchini,Chris C. A. Spencer,Bryan Howie,H. T. Leung,Annette M. Hartmann,Hans-Jürgen Möller,Derek W. Morris,Yongyong Shi,Guo Yin Feng,Per Hoffmann,Peter Propping,Catalina Vasilescu,Wolfgang Maier,Marcella Rietschel,Stanley Zammit,Johannes Schumacher,Emma M. Quinn,Thomas G. Schulze,Nigel Williams,Ina Giegling,Nakao Iwata,Masashi Ikeda,Ariel Darvasi,Sagiv Shifman,Lin He,Jubao Duan,Alan R. Sanders,Douglas F. Levinson,Pablo V. Gejman,Nancy G. Buccola,Bryan J. Mowry,Robert Freedman,Farooq Amin,Donald W. Black,Jeremy M. Silverman,William Byerley,C. Robert Cloninger,Sven Cichon,Markus M. Nöthen,Michael Gill,Aiden Corvin,Dan Rujescu,George Kirov,Michael John Owen +55 more
TL;DR: Meta-analysis provided strongest evidence for association around ZNF804A and this strengthened when the affected phenotype including bipolar disorder included bipolar disorder and the overall pattern of replication was unlikely to occur by chance.
Journal ArticleDOI
A Highly Significant Association between a COMT Haplotype and Schizophrenia
Sagiv Shifman,Michal Bronstein,Meira Sternfeld,Anne Pisanté-Shalom,Efrat Lev-Lehman,Avraham Weizman,Ilya Reznik,Baruch Spivak,Nimrod Grisaru,Leon Karp,Richard Schiffer,Moshe Kotler,Rael D. Strous,Marnina Swartz-Vanetik,Haim Y. Knobler,Eilat Shinar,Jacques S. Beckmann,Benjamin Yakir,Neil Risch,Naomi B. Zak,Ariel Darvasi +20 more
TL;DR: An efficient approach to gene discovery is reported that found a highly significant association between schizophrenia and a COMT haplotype and can be widely implemented for the genetic dissection of other common diseases.
Journal ArticleDOI
Strategies for mapping and cloning quantitative trait genes in rodents
TL;DR: New resources, such as chromosome substitution strains and the proposed Collaborative Cross, together with new analytical tools, including probabilistic ancestral haplotype reconstruction in outbred mice, Yin–Yang crosses and in silico analysis of sequence variants in many inbred strains, could make QTL cloning tractable.
Journal ArticleDOI
Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women
Sagiv Shifman,Martina Johannesson,Michal Bronstein,Sam X. Chen,David A. Collier,Nicholas John Craddock,Kenneth S. Kendler,Tao Li,Tao Li,Michael Conlon O'Donovan,F. Anthony O'Neill,Michael John Owen,Dermot Walsh,Daniel R. Weinberger,Cuie Sun,Jonathan Flint,Ariel Darvasi +16 more
TL;DR: A genome-wide association scan for schizophrenia in an Ashkenazi Jewish population using DNA pooling found a female-specific association with rs7341475, a SNP in the fourth intron of the reelin (RELN) gene, with a significant gene-sex effect.
Journal ArticleDOI
A High-Resolution Single Nucleotide Polymorphism Genetic Map of the Mouse Genome
Sagiv Shifman,Jordana T. Bell,Richard R. Copley,Martin S. Taylor,Robert W. Williams,Richard Mott,Jonathan Flint +6 more
TL;DR: This work reports the highest density genetic map yet created for any organism, except humans, using more than 10,000 single nucleotide polymorphisms evenly spaced across the mouse genome, and separately for males and females.