Identification of loci associated with schizophrenia by genome-wide association and follow-up

doi:10.1038/NG.201

Journal ArticleDOI

Identification of loci associated with schizophrenia by genome-wide association and follow-up

Michael Conlon O'Donovan, +55 more

- 01 Sep 2008 -

Nature Genetics

- Vol. 40, Iss: 9, pp 1053-1055

Chats0

TLDR

Meta-analysis provided strongest evidence for association around ZNF804A and this strengthened when the affected phenotype including bipolar disorder included bipolar disorder and the overall pattern of replication was unlikely to occur by chance.

Abstract:

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P = 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).

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Biological insights from 108 schizophrenia-associated genetic loci

Stephan Ripke, +354 more

- 24 Jul 2014 -

Nature

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Shaun Purcell, +81 more

- 06 Aug 2009 -

Nature

TL;DR: The extent to which common genetic variation underlies the risk of schizophrenia is shown, using two analytic approaches, and the major histocompatibility complex is implicate, which is shown to involve thousands of common alleles of very small effect.

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Oliver D. Howes, +1 more

- 01 May 2009 -

Schizophrenia Bulletin

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Eric J. Nestler, +1 more

- 01 Oct 2010 -

Nature Neuroscience

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