S
Samuel R Josephsen
Researcher at Allen Institute for Brain Science
Publications - 5
Citations - 456
Samuel R Josephsen is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Visual cortex & Dementia. The author has an hindex of 3, co-authored 5 publications receiving 291 citations. Previous affiliations of Samuel R Josephsen include University of Washington.
Papers
More filters
Journal ArticleDOI
Classification of electrophysiological and morphological neuron types in the mouse visual cortex.
Nathan W. Gouwens,Staci A. Sorensen,Jim Berg,Changkyu Lee,Tim Jarsky,Jonathan T. Ting,Susan M. Sunkin,David Feng,Costas A. Anastassiou,Eliza Barkan,Kris Bickley,Nicole Blesie,Thomas Braun,Krissy Brouner,Agata Budzillo,Shiella Caldejon,Tamara Casper,Dan Castelli,Peter Chong,Kirsten Crichton,Christine Cuhaciyan,Tanya L. Daigle,Rachel A. Dalley,Nick Dee,Tsega Desta,Songlin Ding,Samuel Dingman,Alyse Doperalski,Nadezhda Dotson,Tom Egdorf,Michael S. Fisher,Rebecca de Frates,Emma Garren,Marissa Garwood,Amanda Gary,Nathalie Gaudreault,Keith B. Godfrey,Melissa Gorham,Hong Gu,Caroline Habel,Kristen Hadley,James Harrington,Julie A. Harris,Alex M. Henry,DiJon Hill,Samuel R Josephsen,Sara Kebede,Lisa Kim,Matthew Kroll,Brian Lee,Tracy Lemon,Katherine E. Link,Xiaoxiao Liu,Brian Long,Rusty Mann,Medea McGraw,Stefan Mihalas,Alice Mukora,Gabe J. Murphy,Lindsay Ng,Kiet Ngo,Thuc Nghi Nguyen,Philip R. Nicovich,Aaron Oldre,Daniel Park,Sheana Parry,Jed Perkins,Lydia Potekhina,David Reid,Miranda Robertson,David Sandman,Martin Schroedter,Cliff Slaughterbeck,Gilberto J. Soler-Llavina,Josef Sulc,Aaron Szafer,Bosiljka Tasic,Naz Taskin,Corinne Teeter,Nivretta Thatra,Herman Tung,Wayne Wakeman,Grace Williams,Rob Young,Zhi Zhou,Colin Farrell,Hanchuan Peng,Michael Hawrylycz,Ed Lein,Lydia Ng,Anton Arkhipov,Amy Bernard,John W. Phillips,Hongkui Zeng,Christof Koch +94 more
TL;DR: A single-cell characterization pipeline is established using standardized patch-clamp recordings in brain slices and biocytin-based neuronal reconstructions to establish a morpho-electrical taxonomy of cell types for the mouse visual cortex via unsupervised clustering analysis of multiple quantitative features.
Journal ArticleDOI
Neuropathological and transcriptomic characteristics of the aged brain.
Jeremy A. Miller,Angela L. Guillozet-Bongaarts,Laura E. Gibbons,Nadia Postupna,Anne Renz,Allison Beller,Susan M. Sunkin,Lydia Ng,Shannon E. Rose,Kimberly A. Smith,Aaron Szafer,Chris Barber,Darren Bertagnolli,Kristopher Bickley,Krissy Brouner,Shiella Caldejon,Mike Chapin,Mindy L Chua,Natalie M Coleman,Eiron Cudaback,Christine Cuhaciyan,Rachel A. Dalley,Nick Dee,Tsega Desta,Tim A. Dolbeare,Nadezhda Dotson,Michael S. Fisher,Nathalie Gaudreault,Garrett Gee,Terri L. Gilbert,Jeff Goldy,Fiona Griffin,Caroline Habel,Zeb Haradon,Nika Hejazinia,Leanne L Hellstern,Steve Horvath,Kim Howard,Robert Howard,Justin Johal,Nikolas L. Jorstad,Samuel R Josephsen,Chihchau L. Kuan,Florence Lai,Eric Lee,Felix Lee,Tracy Lemon,Xianwu Li,Desiree A. Marshall,Jose Melchor,Shubhabrata Mukherjee,Julie Nyhus,Julie Pendergraft,Lydia Potekhina,Elizabeth Rha,Samantha Rice,David Rosen,Abharika Sapru,Aimee Schantz,Elaine Shen,Emily Sherfield,Shu Shi,Andy J. Sodt,Nivretta Thatra,Michael Tieu,Angela M. Wilson,Thomas J. Montine,Eric B. Larson,Amy Bernard,Paul K. Crane,Richard G. Ellenbogen,C. Dirk Keene,Ed S. Lein +72 more
TL;DR: A comprehensive neuropathological, molecular, and transcriptomic characterization of hippocampus and two regions cortex in 107 aged donors from the Adult Changes in Thought study is generated, highlighting the importance of properly controlling for RNA quality when studying dementia.
Posted ContentDOI
Classification of electrophysiological and morphological types in mouse visual cortex
Nathan W. Gouwens,Staci A. Sorensen,Jim Berg,Changkyu Lee,Tim Jarsky,Jonathan T. Ting,Susan M. Sunkin,David Feng,Costas A. Anastassiou,Eliza Barkan,Kris Bickley,Nicole Blesie,Thomas Braun,Krissy Brouner,Agata Budzillo,Shiella Caldejon,Tamara Casper,Dan Castelli,Peter Chong,Kirsten Crichton,Christine Cuhaciyan,Tanya L. Daigle,Rachel A. Dalley,Nick Dee,Tsega Desta,Samuel Dingman,Alyse Doperalski,Nadezhda Dotson,Tom Egdorf,Michael S. Fisher,Rebecca de Frates,Emma Garren,Marissa Garwood,Amanda Gary,Nathalie Gaudreault,Keith B. Godfrey,Melissa Gorham,Hong Gu,Caroline Habel,Kristen Hadley,James Harrington,Julie A. Harris,Alex M. Henry,DiJon Hill,Samuel R Josephsen,Sara Kebede,Lisa Kim,Matthew Kroll,Brian Lee,Tracy Lemon,Xiaoxiao Liu,Brian Long,Rusty Mann,Medea McGraw,Stefan Mihalas,Alice Mukora,Gabe J. Murphy,Lindsay Ng,Kiet Ngo,Thuc Nghi Nguyen,Philip R. Nicovich,Aaron Oldre,Daniel Park,Sheana Parry,Jed Perkins,Lydia Potekhina,David Reid,Miranda Robertson,David Sandman,Martin Schroedter,Cliff Slaughterbeck,Gilberto J. Soler-Llavina,Josef Sulc,Aaron Szafer,Bosiljka Tasic,Naz Taskin,Corinne Teeter,Nivretta Thatra,Herman Tung,Wayne Wakeman,Grace Williams,Rob Young,Zhi Zhou,Colin Farrell,Hanchuan Peng,Michael Hawrylycz,Ed Lein,Lydia Ng,Anton Arkhipov,Amy Bernard,John W. Phillips,Hongkui Zeng,Christof Koch +92 more
TL;DR: A taxonomy of morphologically- and electrophysiologically-defined cell types for this region of cortex is established with 17 e-types and 35 m-types, as well as an initial correspondence with previously-defined transcriptomic cell types using the same transgenic mouse lines.
Journal ArticleDOI
Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice.
Yue Yang,Macarena S. Aloi,Eiron Cudaback,Samuel R Josephsen,Samantha Rice,Nikolas L. Jorstad,C. Dirk Keene,Thomas J. Montine +7 more
TL;DR: The results showed that wt bone marrow transplantation (BMT) partially reconstituted progranulin in the periphery and in cerebral cortex of Grn−/− mice and suggest that BMT can be administered as a stem cell-based approach to prevent or to treat neurodegenerative diseases.
Peer ReviewDOI
Author response: Neuropathological and transcriptomic characteristics of the aged brain
Jeremy A. Miller,Angela L. Guillozet-Bongaarts,Laura E. Gibbons,Nadia Postupna,Anne Renz,Allison Beller,Susan M. Sunkin,Lydia Ng,Shannon E. Rose,Kimberly A. Smith,Aaron Szafer,Chris Barber,Darren Bertagnolli,Kristopher Bickley,Krissy Brouner,Shiella Caldejon,Mike Chapin,Mindy L Chua,Natalie M Coleman,Eiron Cudaback,Christine Cuhaciyan,Rachel A. Dalley,Nick Dee,Tsega Desta,Tim A. Dolbeare,Nadezhda Dotson,Michael S. Fisher,Nathalie Gaudreault,Garrett Gee,Terri L. Gilbert,Jeff Goldy,Fiona Griffin,Caroline Habel,Zeb Haradon,Nika Hejazinia,Leanne L Hellstern,Steve Horvath,Kim Howard,Robert Howard,Justin Johal,Nikolas L. Jorstad,Samuel R Josephsen,Chihchau L. Kuan,Florence Lai,Eric Lee,Felix Lee,Tracy Lemon,Xianwu Li,Desiree A. Marshall,Jose Melchor,Shubhabrata Mukherjee,Julie Nyhus,Julie Pendergraft,Lydia Potekhina,Elizabeth Rha,Samantha Rice,David Rosen,Abharika Sapru,Aimee Schantz,Elaine Shen,Emily Sherfield,Shu Shi,Andy J. Sodt,Nivretta Thatra,Michael Tieu,Angela M. Wilson,Thomas J. Montine,Eric B. Larson,Amy Bernard,Paul K. Crane,Richard G. Ellenbogen,C. Dirk Keene,Ed S. Lein +72 more