S
Sandra M. Bell
Researcher at University of Leeds
Publications - 56
Citations - 5015
Sandra M. Bell is an academic researcher from University of Leeds. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 28, co-authored 54 publications receiving 4666 citations. Previous affiliations of Sandra M. Bell include Leeds General Infirmary & St James's University Hospital.
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Journal ArticleDOI
Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study
H J N Andreyev,A. R. Norman,David Cunningham,Jacqui Oates,B. R. Dix,Barry Iacopetta,J. Young,T. Walsh,Robyn L. Ward,Nicholas J. Hawkins,M. Beranek,P. Jandik,Robert Benamouzig,E. Jullian,Pierre Laurent-Puig,Sylviane Olschwang,Oliver Müller,Ingrid Hoffmann,H. M. Rabes,C. Zietz,C. Troungos,C. Valavanis,S T Yuen,Jwc Ho,C. T. Croke,D. P. O'Donoghue,Walter Giaretti,A. Rapallo,Antonio Russo,Viviana Bazan,M. Tanaka,K. Omura,T. Azuma,Toshifumi Ohkusa,Takahiro Fujimori,Y. Ono,M. Pauly,C. Faber,R. Glaesener,A.F.P.M. de Goeij,Jan-Willem Arends,S. N. Andersen,T. Lovig,J. Breivik,Gustav Gaudernack,Ole Petter F. Clausen,P.M. De Angelis,G. I. Meling,T. O. Rognum,R. Smith,H S Goh,A. Font,Rafael Rosell,Xiao-Feng Sun,Hong Zhang,J. Benhattar,L. Losi,Jenq Chang Lee,Shan Tair Wang,Paul A. Clarke,Sandra M. Bell,Philip Quirke,Vivien J. Bubb,J. Piris,N. R. Cruickshank,Dion Morton,J. C. Fox,Fahd Al-Mulla,N. Lees,C. N. Hall,D. Snary,K. Wilkinson,Deborah A. Dillon,Jose Costa,V. E. Pricolo,S. D. Finkelstein,J. S. Thebo,Anthony J. Senagore,S. A. Halter,S. Wadler,S Malik,K. Krtolica,N. Urosevic +82 more
TL;DR: In this paper, the effect of the Kirsten ras (Ki-ras) tumour genotype and outcome of patients with colorectal cancer was investigated using a multivariate analysis.
Journal ArticleDOI
A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets
Niantao Deng,Liang Kee Goh,Hannah Wang,Kakoli Das,Jiong Tao,Iain Beehuat Tan,Shenli Zhang,Minghui Lee,Jeanie Wu,Kiat Hon Lim,Zhengdeng Lei,Glenn Goh,Qing-Yan Lim,Angie Lay-Keng Tan,Dianne Yu Sin Poh,Sudep Riahi,Sandra M. Bell,Michael M. Shi,Ronald Linnartz,Feng-Cai Zhu,Khay Guan Yeoh,Han Chong Toh,Wei Peng Yong,Hyun Cheol Cheong,Sun Young Rha,Alex Boussioutas,Heike Grabsch,Steve Rozen,Patrick Tan +28 more
TL;DR: The study demonstrates the existence of five distinct gastric cancer patient subgroups, defined by the signature genomic alterations FGFR2 (9% of tumours), KRAS (9%), EGFR (8%), ERBB2 (7%) and MET (4%).
Journal ArticleDOI
Identification of Microcephalin, a Protein Implicated in Determining the Size of the Human Brain
Andrew P. Jackson,Andrew P. Jackson,Helen Eastwood,Sandra M. Bell,Jimi Adu,Carmel Toomes,Ian M. Carr,Emma Roberts,Daniel J. Hampshire,Yanick J. Crow,Yanick J. Crow,Alan J. Mighell,G. Karbani,Hussain Jafri,Yasmin Rashid,Robert F. Mueller,Robert F. Mueller,Alexander F. Markham,C. Geoffrey Woods,C. Geoffrey Woods +19 more
TL;DR: It is reported that a gene within this interval, encoding a BRCA1 C-terminal domain-containing protein, is mutated in MCPH1 families sharing an ancestral 8p23 haplotype, and this gene, microcephalin, is expressed in the developing cerebral cortex of the fetal brain.
Journal ArticleDOI
Real-time PCR based on SYBR-Green I fluorescence: An alternative to the TaqMan assay for a relative quantification of gene rearrangements, gene amplifications and micro gene deletions
Frederique Ponchel,Carmel Toomes,Kieran Bransfield,Fong T Leong,Susan H. Douglas,Sarah L. Field,Sandra M. Bell,Valérie Combaret,Alain Puisieux,Alan J. Mighell,Philip A. Robinson,Chris F. Inglehearn,John D. Isaacs,Alex F. Markham +13 more
TL;DR: A new assay based on SYBR-Green I binding that is quick, reliable, easily optimised and compares well with the published assay, providing accurate diagnostic results in less time, from less biopsy material and at less cost than assays currently employed such as FISH or Southern blotting.
Journal ArticleDOI
Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer
Sandra M. Bell,Sandra M. Bell,Nigel Scott,Nigel Scott,D Cross,D Cross,Peter M. Sagar,Peter M. Sagar,F A Lewis,F A Lewis,G. Eric Blair,G. Eric Blair,Graham R. Taylor,Graham R. Taylor,Michael F. Dixon,Michael F. Dixon,Philip Quirke,Philip Quirke +17 more
TL;DR: Screening for multiple genetic abnormalities in colorectal cancers excised at surgery may prove to be a useful tool in determining prognosis.