J
Jwc Ho
Researcher at University of Hong Kong
Publications - 11
Citations - 1071
Jwc Ho is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Gene mutation & Colorectal cancer. The author has an hindex of 5, co-authored 11 publications receiving 1037 citations.
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Journal ArticleDOI
Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study
H J N Andreyev,A. R. Norman,David Cunningham,Jacqui Oates,B. R. Dix,Barry Iacopetta,J. Young,T. Walsh,Robyn L. Ward,Nicholas J. Hawkins,M. Beranek,P. Jandik,Robert Benamouzig,E. Jullian,Pierre Laurent-Puig,Sylviane Olschwang,Oliver Müller,Ingrid Hoffmann,H. M. Rabes,C. Zietz,C. Troungos,C. Valavanis,S T Yuen,Jwc Ho,C. T. Croke,D. P. O'Donoghue,Walter Giaretti,A. Rapallo,Antonio Russo,Viviana Bazan,M. Tanaka,K. Omura,T. Azuma,Toshifumi Ohkusa,Takahiro Fujimori,Y. Ono,M. Pauly,C. Faber,R. Glaesener,A.F.P.M. de Goeij,Jan-Willem Arends,S. N. Andersen,T. Lovig,J. Breivik,Gustav Gaudernack,Ole Petter F. Clausen,P.M. De Angelis,G. I. Meling,T. O. Rognum,R. Smith,H S Goh,A. Font,Rafael Rosell,Xiao-Feng Sun,Hong Zhang,J. Benhattar,L. Losi,Jenq Chang Lee,Shan Tair Wang,Paul A. Clarke,Sandra M. Bell,Philip Quirke,Vivien J. Bubb,J. Piris,N. R. Cruickshank,Dion Morton,J. C. Fox,Fahd Al-Mulla,N. Lees,C. N. Hall,D. Snary,K. Wilkinson,Deborah A. Dillon,Jose Costa,V. E. Pricolo,S. D. Finkelstein,J. S. Thebo,Anthony J. Senagore,S. A. Halter,S. Wadler,S Malik,K. Krtolica,N. Urosevic +82 more
TL;DR: In this paper, the effect of the Kirsten ras (Ki-ras) tumour genotype and outcome of patients with colorectal cancer was investigated using a multivariate analysis.
Kirsten ras mutations in patients with colorectal cancer : the ‘RASCAL II’ study
H. J. N. Andreyev,A. R. Norman,David Cunningham,Jacqui Oates,B. R. Dix,Barry Iacopetta,J. Young,T. Walsh,Robyn L. Ward,Nicholas J. Hawkins,M. Beranek,P. Jandik,Robert Benamouzig,Eric Jullian,Pierre Laurent-Puig,Sylviane Olschwang,Oliver Müller,Ingrid Hoffmann,H. M. Rabes,C. Zietz,C. Troungos,C. Valavanis,S T Yuen,Jwc Ho,C. T. Croke,D. P. O'Donoghue,Walter Giaretti,A. Rapallo,Antonio Russo,Bazan,M. Tanaka,K. Omura,T. Azuma,Toshifumi Ohkusa,Takahiro Fujimori,Y. Ono,M. Pauly,C. Faber,R. Glaesener,A.F.P.M. de Goeij,Jan-Willem Arends,S. N. Andersen,T. Lovig,Jarle Breivik,Gustav Gaudernack,Ole Petter F. Clausen,P.M. De Angelis,Gunn Iren Meling,Torleiv O. Rognum,Richard Smith,H S Goh,A. Font,Rafael Rosell,Xiao-Feng Sun,Hong Zhang,J. Benhattar,L. Losi,J. Q Lee,Shan Tair Wang,Paul A. Clarke,Sandra M. Bell,Philip Quirke,Vivien J. Bubb,J. Piris,N. R. Cruickshank,Dion Morton,J. C. Fox,Fahd Al-Mulla,N. Lees,C. N. Hall,D. Snary,K. Wilkinson,Deborah A. Dillon,Jose Costa,V. E. Pricolo,S. D. Finkelstein,J. S. Thebo,Anthony J. Senagore,S. A. Halter,S. Wadler,S Malik,K. Krtolica,N. Urosevic +82 more
TL;DR: It is suggested that not only is the presence of a codon 12 glycine to valine mutation important for cancer progression but also that it may predispose to more aggressive biological behaviour in patients with advanced colorectal cancer.
Journal ArticleDOI
COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.
Ian Tomlinson,Malcolm G. Dunlop,Harry Campbell,Brent W. Zanke,Brent W. Zanke,Brent W. Zanke,Steve Gallinger,Steve Gallinger,Thomas J. Hudson,Thibaud Koessler,Paul D.P. Pharoah,I. Niittymäkix,S. Tuupanenx,Lauri A. Aaltonen,Kari Hemminki,Annika Lindblom,Asta Försti,Oliver M. Sieber,Lara Lipton,T. van Wezel,Hans Morreau,Juul T. Wijnen,Peter Devilee,Koichi Matsuda,Yusuke Nakamura,Sergi Castellví-Bel,Clara Ruiz-Ponte,Antoni Castells,Angel Carracedo,Jwc Ho,Pak C. Sham,Robert M.W. Hofstra,Pavel Vodicka,Hermann Brenner,Jochen Hampe,Clemens Schafmayer,Jürgen Tepel,Stefan Schreiber,Henry Völzke,Markus M. Lerch,C. A. Schmidt,Stephan Buch,Victor Moreno,Cristina M. Villanueva,Paolo Peterlongo,Paolo Radice,Magdalena Echeverry,Alejandro Vélez,Luis G. Carvajal-Carmona,Luis G. Carvajal-Carmona,Rodney J. Scott,Steven Penegar,Peter Broderick,Albert Tenesa,Richard S. Houlston +54 more
TL;DR: The rationale for identifying low-penetrance variants for CRC and the proposed strategy for establishing COGENT are reviewed.
Journal ArticleDOI
Colorectal carcinoma in Hong Kong: epidemiology and genetic mutations.
S T Yuen,Lap Ping Chung,Suet Yi Leung,I. S. C. Luk,S. Y. Chan,J. C. I. Ho,Jwc Ho,Andrew H. Wyllie +7 more
TL;DR: The high incidence of colorectal carcinoma in young people and the raised proportion of frameshift mutations in p53 encourage further search for a genetic basis for susceptibility to this disease in the Hong Kong Chinese population.