S
Scott J. Hultgren
Researcher at Washington University in St. Louis
Publications - 393
Citations - 42958
Scott J. Hultgren is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Pilus & Bacterial adhesin. The author has an hindex of 109, co-authored 380 publications receiving 38674 citations. Previous affiliations of Scott J. Hultgren include University College London & Vrije Universiteit Brussel.
Papers
More filters
Journal ArticleDOI
Urinary tract infections: epidemiology, mechanisms of infection and treatment options
TL;DR: How basic science studies are elucidating the molecular details of the crosstalk that occurs at the host–pathogen interface, as well as the consequences of these interactions for the pathophysiology of UTIs is discussed.
Journal ArticleDOI
Role of Escherichia coli Curli Operons in Directing Amyloid Fiber Formation
Matthew George Chapman,Lloyd S. Robinson,Jerome S. Pinkner,Robyn Roth,John E. Heuser,Mårten Hammar,Staffan Normark,Scott J. Hultgren +7 more
TL;DR: Biochemical, biophysical, and imaging analyses revealed that fibers produced by Escherichia coli called curli were amyloid, and curli biogenesis was dependent on the nucleation-precipitation machinery requiring the CsgE and CsgF chaperone-like and nucleator proteins, respectively.
Journal ArticleDOI
Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense
Carole L. Wilson,Andre J. Ouellette,Donald P. Satchell,Tokiyoshi Ayabe,Yolanda S. López-Boado,Jennifer L. Stratman,Scott J. Hultgren,Lynn M. Matrisian,William C. Parks +8 more
TL;DR: This article showed that matrilysin functions in intestinal mucosal defense by regulating the activity of defensins, which may be a common role for this metalloproteinase in its numerous epithelial sites of expression.
Journal ArticleDOI
Intracellular bacterial biofilm-like pods in urinary tract infections
Gregory G. Anderson,Joseph J. Palermo,Joel D. Schilling,Robyn Roth,John E. Heuser,Scott J. Hultgren +5 more
TL;DR: It is discovered that the intracellular bacteria matured into biofilms, creating pod-like bulges on the bladder surface, which explains how bladder infections can persist in the face of robust host defenses.
Journal ArticleDOI
Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli.
Matthew A. Mulvey,Yolanda S. López-Boado,Carole L. Wilson,Robyn Roth,William C. Parks,John E. Heuser,Scott J. Hultgren +6 more
TL;DR: Bacterial attachment resulted in exfoliation of host bladder epithelial cells as part of an innate host defense system through a rapid apoptosis-like mechanism involving caspase activation and host DNA fragmentation.