Serge Gauthier

TL;DR: It is found that the concentration of the 5-HT metabolite 5-hy-droxyindoleacetic acid (5-HI A A) is low in the lumbar cerebrospinal fluid (CSF) of folate-deficient patients who have folATE-responsive neuropsychiatrie symptoms, and low brain 5- HT levels in the brains of rats fed folate -deficient or over-supplemented diets.

TL;DR: This evaluation shows an [18F]MK-6240 distribution in concordance with postmortem studies and that simplified quantitative approaches such as the SUVR offer valid estimates of neurofibrillary tangle load 90 min post injection.

TL;DR: Occupational therapy should include the assessment of spatial orientation skills in persons who are in the early stages of dementia, because spatial disorientation poses a danger and limits a person's ability to independently perform daily activities that require navigation outside of the home.

TL;DR: The results showed that the subjects of the treated experimental group maintained their functional status after 1 year, demonstrated a significant decrease of bradykinesia, and perceived a significant improvement in their psychological well-being.

TL;DR: Alzhemed appears to be well tolerated with long-term exposure and reduces CSF Abeta(42) levels in mild-to-moderate AD subjects, and these findings will be discussed in the context of two large-scale randomized, double-blind, placebo-controlled Phase III clinical trials that are currently being conducted to test the long- term safety and efficacy of Alzhemed.