S
Serge Gauthier
Researcher at McGill University
Publications - 715
Citations - 61038
Serge Gauthier is an academic researcher from McGill University. The author has contributed to research in topics: Dementia & Disease. The author has an hindex of 93, co-authored 637 publications receiving 52775 citations. Previous affiliations of Serge Gauthier include Hamamatsu University School of Medicine & La Salle University.
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Research update on Alzheimer's disease and introduction to the Expert Review of Neurotherapeutics special issue.
TL;DR: Current trial designs where drugs are simply added on to each other do not allow to adequately measure positive (synergistic) and negative interactions, and none has been demonstrated to achieve disease modification.
Posted ContentDOI
Open Science Datasets from PREVENT-AD, a Longitudinal Cohort of Pre-symptomatic Alzheimer’s Disease
Jennifer Tremblay-Mercier,Cécile Madjar,Cécile Madjar,Samir Das,Alexa Pichet Binette,Alexa Pichet Binette,Stephanie O.M. Dyke,Stephanie O.M. Dyke,Pierre Etienne,Pierre Etienne,Marie-Elyse Lafaille-Magnan,Marie-Elyse Lafaille-Magnan,Marie-Elyse Lafaille-Magnan,Jordana Remz,Pierre Bellec,D. Louis Collins,D. Louis Collins,M. Natasha Rajah,M. Natasha Rajah,Véronique D. Bohbot,Véronique D. Bohbot,Jeannie Marie S. Leoutsakos,Yasser Iturria-Medina,Yasser Iturria-Medina,Justin Kat,Justin Kat,Richard D. Hoge,Serge Gauthier,Serge Gauthier,Christine L. Tardif,Christine L. Tardif,M. Mallar Chakravarty,M. Mallar Chakravarty,Jean-Baptiste Poline,Jean-Baptiste Poline,Pedro Rosa-Neto,Alan C. Evans,Sylvia Villeneuve,Judes Poirier,Judes Poirier,John C.S. Breitner,John C.S. Breitner +41 more
TL;DR: The creation of an open science dataset from a cohort of cognitively unimpaired aging individuals with a parental or multiple-sibling history of Alzheimer’s disease to enable PResymptomatic EValuation of Novel or Experimental Treatments for AD is described.
Journal ArticleDOI
Current status of levodopa therapy in idiopathic Parkinson's disease.
Serge Gauthier,Louise Gauthier +1 more
TL;DR: An inverse correlation was found between age and wearing off, suggesting a marked sensitivity of younger patients to levodopa, and future studies on the use of dopamine agonists should be stratified according to age.
Journal ArticleDOI
Treatment of vascular dementia-evidence from clinical trials with cholinesterase inhibitors.
TL;DR: Control clinical trials with donepezil, galantamine, and rivastigmine in VaD, as well as in patients with AD plus CVD, have demostrated improvement in cognition, behavior and activites of daily living.
Journal ArticleDOI
Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study
Emma L. van der Ende,Carolin Heller,Aitana Sogorb-Esteve,Imogen Swift,David McFall,Georgia Peakman,Arabella Bouzigues,Jackie M. Poos,Lize C. Jiskoot,Jessica L. Panman,Janne M. Papma,Lieke H.H. Meeter,Elise G.P. Dopper,Emily Todd,David M. Cash,Caroline Graff,Matthis Synofzik,Fermin Moreno,Elizabeth Finger,Raquel Sánchez-Valle,Rik Vandenberghe,Robert Laforce,Mario Masellis,Maria Carmela Tartaglia,James B. Rowe,Christopher C Butler,Simon Ducharme,Alexander Gerhard,Adrian Danek,Johannes Levin,Yolande A.L. Pijnenburg,Markus Otto,S. Borroni,Fabrizio Tagliavini,Alexandre de Mendonça,Isabel Santana,Daniela Galimberti,Sandro Sorbi,Henrik Zetterberg,Eric J. Huang,John C. van Swieten,Jonathan D. Rohrer,Harro Seelaar,Sónia Afonso,Maria Rosário Almeida,Sarah Anderl-Straub,Christin Andersson,A. Antonelli,Silvana Archetti,Andrea Arighi,Mircea Balasa,Myriam Barandiaran,Núria Bargalló,Robart Bartha,Benjamin Bender,Alberto Benussi,Luisa Benussi,Valentina Bessi,Giuliano Binetti,Sandra E. Black,Martina Bocchetta,Sergi Borrego-Écija,Jose Bras,Rose Bruffaerts,Marta Cañada,Valentina Cantoni,Paola Caroppo,Miguel Castelo-Branco,Rhian S Convery,Thomas E. Cope,Giuseppe Di Fede,Alina Díez,Diana Duro,Chiara Fenoglio,Camilla Ferrari,Catarina Beatriz Silva Ferreira,Nick C. Fox,Morris Freedman,Giorgio G. Fumagalli,Alazne Gabilondo,Roberto Gasparotti,Serge Gauthier,Stefano Gazzina,Giorgio Giaccone,Ana Gorostidi,Caroline V. Greaves,Rita Guerreiro,Tobias Hoegen,Begoña Indakoetxea,Vesna Jelic,Hans-Otto Karnath,Ron Keren,Tobias Langheinrich,Maria João Leitão,Albert Lladó,Gemma Lombardi,Sandra V. Loosli,Carolina Maruta,Simon Head,Gabriel Miltenberger,Rick van Minkelen,Sara Mitchell,Katrina M. Moore,Benedetta Nacmias,Jennifer M. Nicholas,Linn Öijerstedt,Jaume Olives,Sebastien Ourselin,Alessandro Padovani,Michela Pievani,Cristina Polito,Enrico Premi,Sara Prioni,Catharina Prix,Rosa Rademakers,Veronica Redaelli,Timothy Rittman,Ekaterina Rogaeva,Pedro Rosa-Neto,Giacomina Rossi,Martin Rosser,Beatriz Santiago,Elio Scarpini,Sonja Schönecker,Elisa Semler,Rachelle Shafei,Christen Shoesmith,Miguel Tábuas-Pereira,Mikel Tainta,Ricardo Taipa,David F. Tang-Wai,David L. Thomas,Paul Thompson,Håkan Thonberg,C. Timberlake,Pietro Tiraboschi,Philip Van Damme,Mathieu Vandenbulcke,Michele Veldsman,Ana Verdelho,Jorge Villanua,Jason D. Warren,Carlo Wilke,Ione O.C. Woollacott,Elisabeth Wlasich,Miren Zulaica +145 more
TL;DR: In this paper , the value of complement proteins, which are key components of innate immunity, as biomarkers in cerebrospinal fluid (CSF) and plasma of presymptomatic and symptomatic genetic FTD mutation carriers was determined.