S
Serge Gauthier
Researcher at McGill University
Publications - 715
Citations - 61038
Serge Gauthier is an academic researcher from McGill University. The author has contributed to research in topics: Dementia & Disease. The author has an hindex of 93, co-authored 637 publications receiving 52775 citations. Previous affiliations of Serge Gauthier include Hamamatsu University School of Medicine & La Salle University.
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Frequency of biologically-defined AD in relation to age, sex, APOEε4 and cognitive impairment
Joseph Therriault,Joseph Therriault,Tharick A. Pascoal,Tharick A. Pascoal,Andrea Lessa Benedet,Andrea Lessa Benedet,Cecile Tissot,Cecile Tissot,Melissa Savard,Mira Chamoun,Firoza Z. Lussier,Firoza Z. Lussier,Min Su Kang,Min Su Kang,Gleb Berzgin,Gleb Berzgin,Tina Wang,Tina Wang,Jaime Fernandes-Arias,Jaime Fernandes-Arias,Gassan Massarweh,Gassan Massarweh,Jean-Paul Soucy,Jean-Paul Soucy,Paolo Vitali,Paramita Saha-Chaudhuri,Serge Gauthier,Pedro Rosa-Neto +27 more
TL;DR: In this article, the frequency of biologically defined Alzheimer disease (AD) in relation to age, sex, APOE e4, and clinical diagnosis was assessed in a prospective cohort study evaluated with amyloid-PET and tau-PET.
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Detection of mild cognitive impairment in middle-aged and older adults with obstructive sleep apnoea
Katia Gagnon,Andrée-Ann Baril,Jacques Montplaisir,Julie Carrier,Sirin Chami,Serge Gauthier,Chantal Lafond,Jean-François Gagnon,Nadia Gosselin +8 more
TL;DR: The Montreal Cognitive Assessment performs better than the Mini-Mental State Examination in detecting cognitive impairment in individuals with obstructive sleep apnoea and clinicians should refer patients for neuropsychological assessment when neurodegenerative processes are suspected.
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Association of locus coeruleus integrity with Braak stage and neuropsychiatric symptom severity in Alzheimer’s disease
Clifford M. Cassidy,Joseph Therriault,Tharick A. Pascoal,Victoria Cheung,Melissa Savard,Lauri Tuominen,Mira Chamoun,Adelina McCall,Seyda Nur Celebi,Firoza Z. Lussier,Gassan Massarweh,Jean-Paul Soucy,David Weinshenker,Christine L. Tardif,Zahinoor Ismail,Serge Gauthier,Pedro Rosa-Neto +16 more
TL;DR: In this article , the authors examined whether integrity of the LC-norepinephrine system, assessed with NM-MRI, is associated with stage of Alzheimer's disease and with neuropsychiatric symptoms.
Journal ArticleDOI
Amyloid and Tau Signatures of Brain Metabolic Decline in Preclinical Alzheimer's Disease
Tharick A. Pascoal,Sulantha Mathotaarachchi,Monica Shin,Ah Yeon Park,Sara Mohades,Andrea Lessa Benedet,Min Su Kang,Gassan Massarweh,Jean-Paul Soucy,Jean-Paul Soucy,Serge Gauthier,Pedro Rosa-Neto +11 more
TL;DR: The new concept that combined Aβ and tau thresholds can predict imminent neurodegeneration as an alternative framework with a high statistical power for testing the effect of disease-modifying therapies on [18F]FDG uptake decline over a typical 2-year clinical trial period in individuals with preclinical AD is highlighted.
Journal ArticleDOI
Ethical issues in Alzheimer's disease: an overview.
Antoine Leuzy,Serge Gauthier +1 more
TL;DR: Advances in the neurobiology of AD have translated into an increasing shift toward the diagnosis being made in its pre-dementia stages, when patients have full insight into their prognosis, and new drugs in the near future will require careful stopping rules.