S
Serge Gauthier
Researcher at McGill University
Publications - 715
Citations - 61038
Serge Gauthier is an academic researcher from McGill University. The author has contributed to research in topics: Dementia & Disease. The author has an hindex of 93, co-authored 637 publications receiving 52775 citations. Previous affiliations of Serge Gauthier include Hamamatsu University School of Medicine & La Salle University.
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Journal ArticleDOI
A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease.
Stephen Salloway,Martin R. Farlow,Eric McDade,David B. Clifford,Guoqiao Wang,Jorge J. Llibre-Guerra,Janice M. Hitchcock,Susan Mills,Anna Santacruz,Andrew J. Aschenbrenner,Jason Hassenstab,Tammie L.S. Benzinger,Brian A. Gordon,Anne M. Fagan,Kelley Coalier,Carlos Cruchaga,Alison Goate,Richard J. Perrin,Chengjie Xiong,Yan Li,John C. Morris,B. Joy Snider,Catherine J. Mummery,G. Mustafa Surti,Didier Hannequin,David Wallon,Sarah B. Berman,James J. Lah,Ivonne Z. Jimenez-Velazquez,Erik D. Roberson,Christopher H. van Dyck,Lawrence S. Honig,Raquel Sánchez-Valle,William S. Brooks,Serge Gauthier,Douglas Galasko,Colin L. Masters,Jared R. Brosch,Ging-Yuek Robin Hsiung,Suman Jayadev,Maïté Formaglio,Mario Masellis,Roger Clarnette,J. Pariente,Bruno Dubois,Florence Pasquier,Clifford R. Jack,Robert A. Koeppe,Peter J. Snyder,Paul S. Aisen,Ronald G. Thomas,Scott M. Berry,Barbara A. Wendelberger,Scott W. Andersen,Karen C. Holdridge,Mark A. Mintun,Roy Yaari,John R. Sims,Monika Baudler,Paul Delmar,Rachelle S. Doody,Paulo Fontoura,Caroline Giacobino,Geoffrey A. Kerchner,Randall J. Bateman +64 more
TL;DR: A randomized, placebo-controlled, multi-arm trial of gantenerumab or solanezumab in participants with DIAD across asymptomatic and symptomatic disease stages was conducted in this paper.
Journal ArticleDOI
Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer's Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial.
Gordon K. Wilcock,Serge Gauthier,Giovanni B. Frisoni,Jianping Jia,Jiri Hardlund,Hans J Moebius,Peter Bentham,Karin A Kook,Bjoern Schelter,Damon Wischik,Charles S Davis,Roger T. Staff,Vesna Vuksanović,Trevor Ahearn,Luc Bracoud,Kohkan Shamsi,Ken Marek,John Seibyl,Gernot Riedel,John Storey,Charles R. Harrington,Claude M. Wischik +21 more
TL;DR: The results are consistent with earlier studies in supporting the hypothesis that LMTM might be effective as monotherapy and that 4 mg twice a day may serve as well as higher doses.
Journal ArticleDOI
Hippocampus and amygdala volumes from magnetic resonance images in children: Assessing accuracy of FreeSurfer and FSL against manual segmentation.
Dorothee Schoemaker,Claudia Buss,Kevin Head,Curt A. Sandman,Elysia Poggi Davis,M. Mallar Chakravarty,Serge Gauthier,Jens C. Pruessner +7 more
TL;DR: The results demonstrate that, at least in a pediatric population, the agreement between amygdala and hippocampus volumes obtained with automated FSL-FIRST and FreeSurfer protocols and those obtained with manual segmentation is not strong.
Book ChapterDOI
The concept of vascular cognitive impairment.
Timo Erkinjuntti,Serge Gauthier +1 more
TL;DR: VCI includes all levels of cognitive decline from mild deficits in one or more cognitive domains to a broad dementia-like syndrome and incorporates the complex interactions between vascular risk factors, CVD etiologies and cellular changes within the brain and cognition.
Journal ArticleDOI
Inhibition impairments in Alzheimer's disease, mild cognitive impairment and healthy aging: effect of congruency proportion in a Stroop task.
TL;DR: Assessment of inhibition and goal maintenance in persons with Alzheimer's disease, mild cognitive impairment, healthy older adults and younger adults shows reduced resistance to interference as a consequence of healthy aging and only partially impaired goal-maintenance capacities.