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Alexander V. Sorokin
Researcher at National Institutes of Health
Publications - 60
Citations - 4236
Alexander V. Sorokin is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Psoriasis. The author has an hindex of 17, co-authored 40 publications receiving 3564 citations. Previous affiliations of Alexander V. Sorokin include Kursk State Medical University.
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Journal ArticleDOI
Comparative genomics of the lactic acid bacteria
Kira S. Makarova,Alexei I. Slesarev,Yuri I. Wolf,Alexander V. Sorokin,Boris Mirkin,Eugene V. Koonin,Andrey R. Pavlov,Nadezhda Pavlova,Valeri N. Karamychev,N. N. Polouchine,V. V. Shakhova,Igor V. Grigoriev,Yunian Lou,D. Rohksar,Susan Lucas,Katherine H. Huang,David Goodstein,Trevor Hawkins,V. Plengvidhya,V. Plengvidhya,Dennis L. Welker,Joanne E. Hughes,Yong Jun Goh,Andrew K. Benson,K. A. Baldwin,Ju-Hoon Lee,I. Diaz-Muniz,B. Dosti,Vladimir V. Smeianov,W. Wechter,Ravi D. Barabote,Graciela L. Lorca,Eric Altermann,Rodolphe Barrangou,Balasubramanian Ganesan,Y. Xie,Helen Rawsthorne,Diana I. Tamir,C. Parker,Frederick Breidt,Frederick Breidt,Jeffery R. Broadbent,Robert W. Hutkins,Daniel J. O'Sullivan,J. L. Steele,Gülhan Ünlü,Milton H. Saier,Todd R. Klaenhammer,Paul G. Richardson,Sergei A. Kozyavkin,Bart C. Weimer,David A. Mills +51 more
TL;DR: Phylogenetic analyses, comparison of gene content across the group, and reconstruction of ancestral gene sets indicate a combination of extensive gene loss and key gene acquisitions via horizontal gene transfer during the coevolution of lactic acid bacteria with their habitats.
Journal ArticleDOI
A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes
Eugene V. Koonin,Natalie D. Fedorova,John D. Jackson,Aviva R. Jacobs,Dmitri M. Krylov,Kira S. Makarova,Raja Mazumder,Raja Mazumder,Sergei L. Mekhedov,Anastasia N. Nikolskaya,B Sridhar Rao,Igor B. Rogozin,Sergei Smirnov,Alexander V. Sorokin,Alexander V. Sverdlov,Sona Vasudevan,Yuri I. Wolf,Jodie J. Yin,Darren A. Natale,Darren A. Natale +19 more
TL;DR: Functional and evolutionary patterns in the recently constructed set of 5,873 clusters of predicted orthologs (eukaryotic orthologous groups or KOGs) from seven eukaryosis genomes are examined, revealing a conserved core of largely essential eukARYotic genes as well as major diversification and innovation associated with evolution of eUKaryotic genomes.
Journal ArticleDOI
Remarkable interkingdom conservation of intron positions and massive, lineage-specific intron loss and gain in eukaryotic evolution.
TL;DR: Almost one-third of the introns in the malaria parasite Plasmodium falciparum are shared with at least one crown group eukaryote; this number indicates that these introns have been conserved through >1.5 billion years of evolution that separate Plas modium from the crown group.
Journal ArticleDOI
The cyanobacterial genome core and the origin of photosynthesis
Armen Y. Mulkidjanian,Eugene V. Koonin,Kira S. Makarova,Sergey L. Mekhedov,Alexander V. Sorokin,Yuri I. Wolf,Alexis Dufresne,Frédéric Partensky,Henry Burd,Denis Kaznadzey,Robert Haselkorn,Michael Y. Galperin +11 more
TL;DR: It is proposed that the first phototrophs were anaerobic ancestors of cyanobacteria (“procyanobacteria”) that conducted anoxygenic photosynthesis using a photosystem I-like reaction center, somewhat similar to the heterocysts of modern filamentous cyanob bacteria.
Journal ArticleDOI
Deinococcus geothermalis: The Pool of Extreme Radiation Resistance Genes Shrinks
Kira S. Makarova,Marina V. Omelchenko,Elena K. Gaidamakova,Vera Y. Matrosova,Alexander Vasilenko,Min Zhai,Alla Lapidus,Alex Copeland,Edwin Kim,Miriam Land,Konstantinos Mavromatis,Samuel Pitluck,Paul G. Richardson,Chris Detter,Thomas Brettin,Elizabeth Saunders,Barry Lai,Bruce Ravel,Kenneth M. Kemner,Yuri I. Wolf,Alexander V. Sorokin,Anna Gerasimova,Mikhail S. Gelfand,James K. Fredrickson,Eugene V. Koonin,Michael J. Daly +25 more
TL;DR: The Deinococcus radiodurans was the first member of this group whose genome was completely sequenced, and a comparative analysis of the two species was performed in this paper.