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Shoichi Hazama
Researcher at Yamaguchi University
Publications - 21
Citations - 1827
Shoichi Hazama is an academic researcher from Yamaguchi University. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 12, co-authored 21 publications receiving 1288 citations.
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Journal ArticleDOI
International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study
Franck Pagès,Bernhard Mlecnik,Florence Marliot,Gabriela Bindea,Gabriela Bindea,Gabriela Bindea,Fang Shu Ou,Carlo Bifulco,Alessandro Lugli,Inti Zlobec,Tilman T. Rau,Martin D. Berger,Iris D. Nagtegaal,Elisa Vink-Börger,Arndt Hartmann,Carol Geppert,Julie Kolwelter,Susanne Merkel,Robert Grützmann,Marc Van den Eynde,Anne Jouret-Mourin,Alex Kartheuser,Daniel Léonard,Christophe Remue,Julia Y. Wang,Julia Y. Wang,Prashant Bavi,Michael H.A. Roehrl,Michael H.A. Roehrl,Michael H.A. Roehrl,Pamela S. Ohashi,Linh T. Nguyen,Seong Jun Han,Heather L. MacGregor,Sara Hafezi-Bakhtiari,Bradly G. Wouters,Giuseppe Masucci,Emilia Andersson,Eva Zavadova,Michal Vocka,Jan Spacek,Lubos Petruzelka,Bohuslav Konopasek,Pavel Dundr,Helena Skalova,Kristyna Nemejcova,Gerardo Botti,Fabiana Tatangelo,Paolo Delrio,Gennaro Ciliberto,Michele Maio,Luigi Laghi,Fabio Grizzi,Tessa Fredriksen,Tessa Fredriksen,Tessa Fredriksen,Bénédicte Buttard,Bénédicte Buttard,Bénédicte Buttard,Mihaela Angelova,Mihaela Angelova,Mihaela Angelova,Angela Vasaturo,Angela Vasaturo,Angela Vasaturo,Pauline Maby,Pauline Maby,Pauline Maby,Sarah E. Church,Helen K. Angell,Lucie Lafontaine,Lucie Lafontaine,Lucie Lafontaine,Daniela Bruni,Daniela Bruni,Daniela Bruni,Carine El Sissy,Nacilla Haicheur,Amos Kirilovsky,Anne Berger,Christine Lagorce,Jeffrey P. Meyers,Christopher Paustian,Zipei Feng,Carmen Ballesteros-Merino,Jeroen R. Dijkstra,Carlijn van de Water,Shannon van Vliet,Nikki Knijn,Ana Maria Mușină,Dragos Viorel Scripcariu,Boryana Popivanova,Mingli Xu,Tomonobu Fujita,Shoichi Hazama,Nobuaki Suzuki,Hiroaki Nagano,Kiyotaka Okuno,Toshihiko Torigoe,Noriyuki Sato,Tomohisa Furuhata,Ichiro Takemasa,Kyogo Itoh,P. Patel,Hemangini H. Vora,Birva Shah,Jayendrakumar B. Patel,Kruti N. Rajvik,Shashank J. Pandya,Shilin N. Shukla,Yili Wang,Guanjun Zhang,Yutaka Kawakami,Francesco M. Marincola,Paolo A. Ascierto,Daniel J. Sargent,Bernard A. Fox,Bernard A. Fox,Jérôme Galon,Jérôme Galon,Jérôme Galon +120 more
TL;DR: The immunoscore provides a reliable estimate of the risk of recurrence in patients with colon cancer and supports the implementation of the consensus Immunoscore as a new component of a TNM-Immune classification of cancer.
Journal ArticleDOI
Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells
Koji Ueno,Shoichi Hazama,S Mitomori,Mitsuaki Nishioka,Yutaka Suehiro,Hiroshi Hirata,M. Oka,Kohzoh Imai,Rajvir Dahiya,Yuji Hinoda +9 more
TL;DR: It is suggested that FZD7 may be involved in enhancement of survival, invasion and metastatic capabilities of colon cancer cells through non-canonical Wnt signalling pathways as well as the canonical pathway.
Journal Article
Impact of Chemotherapy for Colorectal Cancer on Regulatory T-Cells and Tumor Immunity
Kazunari Maeda,Shoichi Hazama,Kazuhisa Tokuno,Shin Kan,Yoshinari Maeda,Yusaku Watanabe,Ryoji Kamei,Yoshitaro Shindo,Noriko Maeda,Kiyoshi Yoshimura,Shigefumi Yoshino,Masaaki Oka +11 more
TL;DR: FOLFOX and FOLFIRI may enhance antitumor immunity via suppression of Tregs and other immune effectors through enhancement of immunological self-tolerance and immune homeostasis.
Journal ArticleDOI
Prospective phase II study of FOLFIRI for mCRC in Japan, including the analysis of UGT1A1 28/6 polymorphisms
Yusuke Okuyama,Shoichi Hazama,Hiroshi Nozawa,Michiya Kobayashi,Kenichi Takahashi,Koshi Fujikawa,Takeshi Kato,Naoki Nagata,Humihiko Kimura,Koji Oba,Junichi Sakamoto,Hideyuki Mishima +11 more
TL;DR: FOLFIRI is effective and tolerable for Japanese metastatic colorectal cancer patients and homozygosity for UGT1A1 28 or 6 and heterozygosity For both UGT 1A128 and 6 and 6 are associated with severe neutropenia.
Journal ArticleDOI
Possible involvement of Wnt11 in colorectal cancer progression.
Mitsuaki Nishioka,Koji Ueno,Shoichi Hazama,Toshiyuki Okada,Kouhei Sakai,Yutaka Suehiro,Naoko Okayama,Hiroshi Hirata,Masaaki Oka,Kohzoh Imai,Rajvir Dahiya,Yuji Hinoda +11 more
TL;DR: The expression levels of candidate FZD7 ligands, Wnt3 and Wnt11 in colon cancer cell lines and primary CRC tissues are measured by quantitative RT‐PCR and suggest that Wnt 11 may play an important role in CRC progression.