H
Heather L. MacGregor
Researcher at Princess Margaret Cancer Centre
Publications - 10
Citations - 1454
Heather L. MacGregor is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Cancer & Biology. The author has an hindex of 3, co-authored 3 publications receiving 914 citations. Previous affiliations of Heather L. MacGregor include University Health Network.
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Journal ArticleDOI
International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study
Franck Pagès,Bernhard Mlecnik,Florence Marliot,Gabriela Bindea,Gabriela Bindea,Gabriela Bindea,Fang Shu Ou,Carlo Bifulco,Alessandro Lugli,Inti Zlobec,Tilman T. Rau,Martin D. Berger,Iris D. Nagtegaal,Elisa Vink-Börger,Arndt Hartmann,Carol Geppert,Julie Kolwelter,Susanne Merkel,Robert Grützmann,Marc Van den Eynde,Anne Jouret-Mourin,Alex Kartheuser,Daniel Léonard,Christophe Remue,Julia Y. Wang,Julia Y. Wang,Prashant Bavi,Michael H.A. Roehrl,Michael H.A. Roehrl,Michael H.A. Roehrl,Pamela S. Ohashi,Linh T. Nguyen,Seong Jun Han,Heather L. MacGregor,Sara Hafezi-Bakhtiari,Bradly G. Wouters,Giuseppe Masucci,Emilia Andersson,Eva Zavadova,Michal Vocka,Jan Spacek,Lubos Petruzelka,Bohuslav Konopasek,Pavel Dundr,Helena Skalova,Kristyna Nemejcova,Gerardo Botti,Fabiana Tatangelo,Paolo Delrio,Gennaro Ciliberto,Michele Maio,Luigi Laghi,Fabio Grizzi,Tessa Fredriksen,Tessa Fredriksen,Tessa Fredriksen,Bénédicte Buttard,Bénédicte Buttard,Bénédicte Buttard,Mihaela Angelova,Mihaela Angelova,Mihaela Angelova,Angela Vasaturo,Angela Vasaturo,Angela Vasaturo,Pauline Maby,Pauline Maby,Pauline Maby,Sarah E. Church,Helen K. Angell,Lucie Lafontaine,Lucie Lafontaine,Lucie Lafontaine,Daniela Bruni,Daniela Bruni,Daniela Bruni,Carine El Sissy,Nacilla Haicheur,Amos Kirilovsky,Anne Berger,Christine Lagorce,Jeffrey P. Meyers,Christopher Paustian,Zipei Feng,Carmen Ballesteros-Merino,Jeroen R. Dijkstra,Carlijn van de Water,Shannon van Vliet,Nikki Knijn,Ana Maria Mușină,Dragos Viorel Scripcariu,Boryana Popivanova,Mingli Xu,Tomonobu Fujita,Shoichi Hazama,Nobuaki Suzuki,Hiroaki Nagano,Kiyotaka Okuno,Toshihiko Torigoe,Noriyuki Sato,Tomohisa Furuhata,Ichiro Takemasa,Kyogo Itoh,P. Patel,Hemangini H. Vora,Birva Shah,Jayendrakumar B. Patel,Kruti N. Rajvik,Shashank J. Pandya,Shilin N. Shukla,Yili Wang,Guanjun Zhang,Yutaka Kawakami,Francesco M. Marincola,Paolo A. Ascierto,Daniel J. Sargent,Bernard A. Fox,Bernard A. Fox,Jérôme Galon,Jérôme Galon,Jérôme Galon +120 more
TL;DR: The immunoscore provides a reliable estimate of the risk of recurrence in patients with colon cancer and supports the implementation of the consensus Immunoscore as a new component of a TNM-Immune classification of cancer.
Journal ArticleDOI
Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer.
Bernhard Mlecnik,Carlo Bifulco,Gabriela Bindea,Gabriela Bindea,Florence Marliot,Alessandro Lugli,J. Jack Lee,Inti Zlobec,Tilman T. Rau,Martin D. Berger,Iris D. Nagtegaal,Elisa Vink-Börger,Arndt Hartmann,Carol Geppert,Julie Kolwelter,Susanne Merkel,Robert Grützmann,Marc Van den Eynde,Anne Jouret-Mourin,Alex Kartheuser,Daniel Léonard,Christophe Remue,Julia Y. Wang,Julia Y. Wang,Prashant Bavi,Michael H.A. Roehrl,Michael H.A. Roehrl,Michael H.A. Roehrl,Pamela S. Ohashi,Linh T. Nguyen,SeongJun Han,Heather L. MacGregor,Sara Hafezi-Bakhtiari,Bradly G. Wouters,Giuseppe Masucci,Emilia Andersson,Eva Zavadova,Michal Vocka,Jan Spacek,Lubos Petruzelka,Bohuslav Konopasek,Pavel Dundr,Helena Skalova,Kristyna Nemejcova,Gerardo Botti,Fabiana Tatangelo,Paolo Delrio,Gennaro Ciliberto,Michele Maio,Luigi Laghi,Fabio Grizzi,Tessa Fredriksen,Tessa Fredriksen,Bénédicte Buttard,Bénédicte Buttard,Lucie Lafontaine,Lucie Lafontaine,Daniela Bruni,Daniela Bruni,Anastasia Lanzi,Anastasia Lanzi,Carine El Sissy,Nacilla Haicheur,Amos Kirilovsky,Anne Berger,Christine Lagorce,Christopher Paustian,Carmen Ballesteros-Merino,Jeroen R. Dijkstra,Carlijn van de Water,Shannon van Lent–van Vliet,Nikki Knijn,Ana-Maria Muşină,Dragos-Viorel Scripcariu,Boryana Popivanova,Mingli Xu,Tomonobu Fujita,Shoichi Hazama,Nobuaki Suzuki,Hiroaki Nagano,Kiyotaka Okuno,Toshihiko Torigoe,Noriyuki Sato,Tomohisa Furuhata,Ichiro Takemasa,Kyogo Itoh,P. Patel,Hemangini H. Vora,Birva Shah,Jayendrakumar B. Patel,Kruti N. Rajvik,Shashank J. Pandya,Shilin N. Shukla,Yili Wang,Guanjun Zhang,Yutaka Kawakami,Francesco M. Marincola,Paolo A. Ascierto,Bernard A. Fox,Franck Pagès,Jérôme Galon,Jérôme Galon +101 more
TL;DR: It is suggested that patients with a high Immunoscore will benefit the most from chemotherapy in terms of recurrence risk, as well as the effect of chemotherapy on time to recurrence (TTR).
Journal ArticleDOI
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts: National Harbor, MD, USA. 9-13 November 2016
Sonja Althammer,Keith Steele,Marlon Rebelatto,Tze Heng Tan,Tobias Wiestler,Guenter Schmidt,Brandon W. Higgs,Xia Li,Li Shi,Xiaoping Jin,Joyce Antal,Ashok Kumar Gupta,Koustubh Ranade,Gerd Binning,Joaquim Bellmunt,Ronald de Wit,David J. Vaughn,Yves Fradet,Jae Lyun Lee,Lawrence Fong,Nicholas J. Vogelzang,Miguel A. Climent,Daniel P. Petrylak,Toni K. Choueiri,Andrea Necchi,Winald R. Gerritsen,Howard Gurney,David I. Quinn,Stéphane Culine,Cora N. Sternberg,Yabing Mai,Markus Puhlmann,Rodolfo F. Perini,Dean F. Bajorin,Padmanee Sharma,Margaret K. Callahan,Emiliano Calvo,Joseph Kim,Filipo de Braud,Patrick A. Ott,Petri Bono,Rathi N. Pillai,Michael A. Morse,Dung T. Le,Matthew H. Taylor,Pavlina Spilliopoulou,Johanna C. Bendell,Dirk Jaeger,Emily Chan,Scott J. Antonia,Paolo A. Ascierto,Delphine Hennicken,Marina Tschaika,Alex Azrilevich,Jonathan E. Rosenberg,Ofer Levy,Christopher T. Chan,Gady Cojocaru,Spencer Liang,Eran Ophir,Sudipto Ganguly,Amir Toporik,Maya Kotturi,Tal Fridman Kfir,Benjamin Murter,Kathryn Logronio,Liat Dassa,Ling Leung,Shirley Greenwald,Meir Azulay,Sandeep Kumar,Zoya Alteber,Xiaoyu Pan,Arthur Machlenkin,Yair Benita,Andrew W. Drake,Ayelet Chajut,Ran Salomon,Ilan Vankin,Einav Safyon,John Hunter,Zurit Levine,Mark White,Rom Leidner,Hyunseok Kang,Robert I. Haddad,Neil H. Segal,Lori J. Wirth,Robert L. Ferris,F. Stephen Hodi,Rachel E. Sanborn,Thomas F. Gajewski,William H. Sharfman,Dan McDonald,Shivani Srivastava,Xuemin Gu,Penny Phillips,Chaitali Passey,Tanguy Y. Seiwert,Tsadik Habtetsion,Gang Zhou,Donastas Sakellariou-Thompson,Cara Haymaker,Caitlin Creasy,Mark W. Hurd,Naohiro Uraoka,Jaime Rodriguez Canales,Scott Koptez,Patrick Hwu,Anirban Maitra,Chantale Bernatchez,Scott M. Coyle,Kole T. Roybel,Levi J. Rupp,Stephen Santoro,Stephanie Secrest,Michael Spelman,Hanson Ho,Tina Gomes,Tiffany Tse,Chia Yung-Wu,Jack Taunton,Wendell A. Lim,Peter Emtage,Tarsem Moudgil,Carmen Ballesteros-Merino,Traci Hilton,Christopher Paustian,David B. Page,Walter J. Urba,Bernard A. Fox,Bryan Bell,Ashish A. Patel,Tove Olafsen,Daulet Satpayev,Michael Torgov,Filippo Marchioni,Jason Romero,Ziyue Karen Jiang,Charles Zamilpa,Jennifer S. Keppler,Alessandro Mascioni,Fang Jia,Chen-Yu Lee,Jean Gudas,Ryan J. Sullivan,Yujin Hoshida,Theodore F. Logan,Nikhil I. Khushalani,Anita Giobbie-Hurder,Kim Margolin,Joanna Roder,Rupal S. Bhatt,Henry B. Koon,Thomas Olencki,Thomas E. Hutson,Brendan D. Curti,Shauna M. Blackmon,James W. Mier,Igor Puzanov,Heinrich Roder,John H. Stewart,Asim Amin,Marc S. Ernstoff,Joseph I. Clark,Michael B. Atkins,Howard L. Kaufman,Jeffrey A. Sosman,Sabina Signoretti,David F. McDermott,Abraham Anderson,Mohammed M. Milhem,Robert H.I. Andtbacka,David R. Minor,Kevin S. Gorski,Daniel M. Baker,Omid Hamid,Emmanuel T. Akporiaye,Yoshinobu Koguchi,Kim Sutcliffe,Kristie Conder,Thomas U. Marron,Nina Bhardwaj,Linda Hammerich,Fiby George,Seunghee Kim-Schulze,Tibor Keler,Thomas Davis,Elizabeth Crowley,Andres Salazar,Joshua Brody,Arta Monjazeb,Megan E. Daly,Jonathan W. Riess,Tianhong Li,William J. Murphy,Karen Kelly,Zhiwei Hu,Rulong Shen,Amanda Campbell,Elizabeth L. McMichael,Lianbo Yu,Bhuvaneswari Ramaswam,Cheryl A. London,Tian Xu,William E. Carson,Kathleen M. Kokolus,Elizabeth A. Repasky,Todd D. Schell,Joseph D. Drabick,David J. Messenheimer,Shawn M. Jensen,Mark P. Rubinstein,Kristina Andrijauskaite,Marzena Swiderska-Syn,Kristin Lind,Agnes Choppin,Marina K. Roell,John Wrangle,Peter R. Rhode,Hing C. Wong,Shamim Ahmad,Mason Webb,Rasha Abu-Eid,Rajeev K. Shrimali,Vivek Verma,Atbin Doroodchi,Zuzana Berrong,David Yashar,Raed Samara,Mikayel Mkrtichyan,Samir N. Khleif,Steven Francis Powell,Mark Gitau,Christopher Sumey,Andrew Terrell,Michele Lohr,Ryan K. Nowak,Steven McGraw,Ash Jensen,Miran Blanchard,Kathryn A. Gold,Ezra E.W. Cohen,Christie Ellison,Lora Black,John K. Lee,William C. Spanos,Erik Wennerberg,Emily Schwitzer,Claire Lhuillier,Graeme J. Koelwyn,Rebecca L. Hiner,Lee W. Jones,Sandra Demaria,Vandeveer Amanda,John W. Greiner,Jeffrey Schlom,Michelle L. Bookstaver,Christopher M. Jewell,Andrew Gunderson,Brian C. Boulmay,Rui Li,Bradley Spieler,Kyle I. Happel,Zipei Feng,Christopher Dubay,Brenda Fisher,Sandra Aung,Eileen Mederos,Carlo Bifulco,Michael McNamara,Keith Bahjat,William Redmond,Augusto C. Ochoa,Hong-Ming Hu,Adi Mehta,Fridtjof Lund-Johansen,Frank Bedu-Addo,Greg Conn,Michael King,Panna Dutta,Robert Shepard,Mark H. Einstein,Sylvia Adams,Ena Wang,Ping Jin,Yelena Novik,Debra J. Morrison,Ruth Oratz,F. M. Marincola,David F. Stroncek,Judith D. Goldberg,Silvia C. Formenti,Jérôme Galon,Bernhard Mlecnik,Florence Marliot,Fang Shu Ou,Alessandro Lugli,Inti Zlobec,Tilman T. Rau,Iris D. Nagtegaal,Elisa Vink-Börger,Arndt Hartmann,Carol Geppert,Michael H.A. Roehrl,Prashant Bavi,Pamela S. Ohashi,Julia Y. Wang,Linh T. Nguyen,SeongJun Han,Heather L. MacGregor,Sara Hafezi-Bakhtiari,Bradley G. Wouters,Yutaka Kawakami,Boryana Papivanova,Mingli Xu,Tomonobu Fujita,Shoichi Hazama,Nobuaki Suzuki,Hiroaki Nagano,Kiyotaka Okuno,Kyogo Itoh,Eva Zavadova,Michal Vocka,Jan Spacek,Lubos Petruzelka,Bohuslav Konopasek,Pavel Dundr,Helena Skalova,Toshihiko Torigoe,Noriyuki Sato,Tomohisa Furuhata,Ichiro Takemasa,Marc Van den Eynde,Anne Jouret-Mourin,Jean-Pascal Machiels,Tessa Fredriksen,Lucie Lafontaine,Bénédicte Buttard,Sarah E. Church,Pauline Maby,Helen K. Angell,Mihaela Angelova,Angela Vasaturo,Gabriela Bindea,Anne Berger,Christine Lagorce,P. Patel,Hemangini H. Vora,Birva Shah,Jayendrakumar B. Patel,Kruti N. Rajvik,Shashank J. Pandya,Shilin N. Shukla,Yili Wang,Guanjun Zhang,Giuseppe Masucci,Emilia Andersson,Fabio Grizzi,Luigi Laghi,Gerardo Botti,Fabiana Tatangelo,Paolo Delrio,Gennaro Cilberto,Franco Marincola,Daniel J. Sargent,Bernard A. Fox,Alain Algazi,Katy K. Tsai,Michael Rosenblum,Prachi Nandoskar,Amy Li,John Nonomura,Kathryn Toshimi Takamura,Mary Dwyer,Erica Browning,Reneta Talia,Chris Twitty,Sharron Gargosky,Jean S. Campbell,Mai Le,Robert H. Pierce,Adil Daud,Robyn D. Gartrell,Douglas K. Marks,Edward C. Stack,Yan Lu,Daisuke Izaki,Kristen M. Beck,Dan Tong Jia,Paul Armenta,Ashley White-Stern,Yichun Fu,Zoe Blake,Bret Taback,Basil A. Horst,Yvonne M. Saenger,Steven Leonardo,Keith Gorden,Ross B. Fulton,Kathryn A. Fraser,Takashi Kangas,Richard Walsh,Kathleen Ertelt,J.N. Graff,Mark T. Uhlik,Jennifer S. Sims,Liang Lei,Takashi Tsujiuchi,Jeffrey N. Bruce,Peter Canoll,Anthony W. Tolcher,Evan W. Alley,Gurunadh Reddy Chichili,Jan E Canoll,Paul Moore,Ezio Bonvini,Syd Johnson,Sadhna Shankar,James Vasselli,Jon M. Wigginton,John Powderly +421 more
TL;DR: O1 Combinatorial CD8+ and PD-L1+ cell densities correlate with response and improved survival in non-small cell lung cancer patients treated with durvalumab.
Journal ArticleDOI
Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study
Bernhard Mlecnik,Toshihiko Torigoe,Gabriela Bindea,Boryana K. Popivanova,Mingli Xu,Tomonobu Fujita,Shoichi Hazama,Nobuaki Suzuki,Hiroaki Nagano,Kiyotaka Okuno,Yoshihiko Hirohashi,Tomohisa Furuhata,Ichiro Takemasa,P. M. Patel,Hemangini H. Vora,Birva A. Shah,Jayendrakumar B. Patel,Kruti N. Rajvik,Shashank J. Pandya,Shilin N. Shukla,Yili Wang,Guanjun Zhang,Takayuki Yoshino,Hiroya Taniguchi,Carlo Bifulco,Alessandro Lugli,J. Lee,Inti Zlobec,Tilman T. Rau,Martin D. Berger,Iris D. Nagtegaal,Elisa Vink-Börger,Arndt Hartmann,Carol Geppert,Julie Kolwelter,Susanne Merkel,Robert Grützmann,Marc Van den Eynde,Anne Jouret-Mourin,Alex Kartheuser,Daniel Léonard,Christophe Remue,Julia Wang,Prashant Bavi,Michael H.A. Roehrl,Pamela S. Ohashi,Linh T. Nguyen,SeongJun Han,Heather L. MacGregor,Sara Hafezi-Bakhtiari,Bradly G. Wouters,Giuseppe Masucci,Emilia Andersson,Eva Zavadova,Michal Vocka,Jan Spacek,Lubos Petruzelka,Bohuslav Konopasek,Pavel Dundr,Helena Skalova,Kristyna Nemejcova,Gerardo Botti,Fabiana Tatangelo,Paolo Delrio,Gennaro Ciliberto,Michele Maio,Luigi Laghi,Fabio Grizzi,Florence Marliot,Tessa Fredriksen,Bénédicte Buttard,Lucie Lafontaine,Pauline Maby,Amine Majdi,Assia Hijazi,Carine El Sissy,Amos Kirilovsky,Anne Berger,Christine Lagorce,Christopher Paustian,Carmen Ballesteros-Merino,J. Dijkstra,Carlijn van de Water,Shannon van Lent–van Vliet,Nikki Knijn,Ana Maria Mușină,Dragos Viorel Scripcariu,Francesco M. Marincola,Paolo A. Ascierto,Bernard A. Fox,Franck Pagès,Yutaka Kawakami,Jérôme Galon +92 more
TL;DR: A High Immunoscore is significantly associated with the prolonged survival of CC patients within the Asian population and showed a significant association with prolonged TTR, OS, and DFS.
Journal ArticleDOI
Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer
Bernhard Mlecnik,Alessandro Lugli,Gabriela Bindea,Florence Marliot,Carlo Bifulco,J. Lee,Inti Zlobec,Tilman T. Rau,Martin D. Berger,Iris D. Nagtegaal,Elisa Vink-Börger,Arndt Hartmann,Carol Geppert,Julie Kolwelter,Susanne Merkel,Robert Grützmann,Marc Van den Eynde,Anne Jouret-Mourin,Alex Kartheuser,Daniel Léonard,Christophe Remue,Julia Wang,Prashant Bavi,Michael H.A. Roehrl,Pamela S. Ohashi,Linh T. Nguyen,SeongJun Han,Heather L. MacGregor,Sara Hafezi-Bakhtiari,Bradly G. Wouters,Giuseppe Masucci,Emilia Andersson,Eva Zavadova,Michal Vocka,Jan Spacek,Lubos Petruzelka,Bohuslav Konopasek,Pavel Dundr,Helena Skalova,Kristyna Nemejcova,Gerardo Botti,Fabiana Tatangelo,Paolo Delrio,Gennaro Ciliberto,Michele Maio,Luigi Laghi,Fabio Grizzi,Tessa Fredriksen,Bénédicte Buttard,Lucie Lafontaine,Pauline Maby,Amine Majdi,Assia Hijazi,Carine El Sissy,Amos Kirilovsky,Anne Berger,Christine Lagorce,Christopher Paustian,Carmen Ballesteros-Merino,J. Dijkstra,Carlijn van de Water,Shannon van Vliet,Nikki Knijn,Ana Maria Mușină,Dragos Viorel Scripcariu,Boryana K. Popivanova,Mingli Xu,Tomonobu Fujita,Shoichi Hazama,Nobuaki Suzuki,Hiroaki Nagano,Kiyotaka Okuno,Toshihiko Torigoe,Noriyuki Sato,Tomohisa Furuhata,Ichiro Takemasa,P. M. Patel,Hemangini H. Vora,Birva A. Shah,Jayendrakumar B. Patel,Kruti N. Rajvik,Shashank J. Pandya,Shilin N. Shukla,Yili Wang,Guanjun Zhang,Yutaka Kawakami,Francesco M. Marincola,Paolo A. Ascierto,Bernard A. Fox,Franck Pagès,Jérôme Galon +90 more
TL;DR: In this paper , the authors determined the predictive value of the consensus Immunoscore in 1885 patients with AJCC/UICC-TNM stage I-II colon cancer from North American, European, and Asian care centers.