B
Boryana Popivanova
Researcher at Keio University
Publications - 6
Citations - 1468
Boryana Popivanova is an academic researcher from Keio University. The author has contributed to research in topics: Cancer & Immunotherapy. The author has an hindex of 3, co-authored 6 publications receiving 928 citations.
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Journal ArticleDOI
International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study
Franck Pagès,Bernhard Mlecnik,Florence Marliot,Gabriela Bindea,Gabriela Bindea,Gabriela Bindea,Fang Shu Ou,Carlo Bifulco,Alessandro Lugli,Inti Zlobec,Tilman T. Rau,Martin D. Berger,Iris D. Nagtegaal,Elisa Vink-Börger,Arndt Hartmann,Carol Geppert,Julie Kolwelter,Susanne Merkel,Robert Grützmann,Marc Van den Eynde,Anne Jouret-Mourin,Alex Kartheuser,Daniel Léonard,Christophe Remue,Julia Y. Wang,Julia Y. Wang,Prashant Bavi,Michael H.A. Roehrl,Michael H.A. Roehrl,Michael H.A. Roehrl,Pamela S. Ohashi,Linh T. Nguyen,Seong Jun Han,Heather L. MacGregor,Sara Hafezi-Bakhtiari,Bradly G. Wouters,Giuseppe Masucci,Emilia Andersson,Eva Zavadova,Michal Vocka,Jan Spacek,Lubos Petruzelka,Bohuslav Konopasek,Pavel Dundr,Helena Skalova,Kristyna Nemejcova,Gerardo Botti,Fabiana Tatangelo,Paolo Delrio,Gennaro Ciliberto,Michele Maio,Luigi Laghi,Fabio Grizzi,Tessa Fredriksen,Tessa Fredriksen,Tessa Fredriksen,Bénédicte Buttard,Bénédicte Buttard,Bénédicte Buttard,Mihaela Angelova,Mihaela Angelova,Mihaela Angelova,Angela Vasaturo,Angela Vasaturo,Angela Vasaturo,Pauline Maby,Pauline Maby,Pauline Maby,Sarah E. Church,Helen K. Angell,Lucie Lafontaine,Lucie Lafontaine,Lucie Lafontaine,Daniela Bruni,Daniela Bruni,Daniela Bruni,Carine El Sissy,Nacilla Haicheur,Amos Kirilovsky,Anne Berger,Christine Lagorce,Jeffrey P. Meyers,Christopher Paustian,Zipei Feng,Carmen Ballesteros-Merino,Jeroen R. Dijkstra,Carlijn van de Water,Shannon van Vliet,Nikki Knijn,Ana Maria Mușină,Dragos Viorel Scripcariu,Boryana Popivanova,Mingli Xu,Tomonobu Fujita,Shoichi Hazama,Nobuaki Suzuki,Hiroaki Nagano,Kiyotaka Okuno,Toshihiko Torigoe,Noriyuki Sato,Tomohisa Furuhata,Ichiro Takemasa,Kyogo Itoh,P. Patel,Hemangini H. Vora,Birva Shah,Jayendrakumar B. Patel,Kruti N. Rajvik,Shashank J. Pandya,Shilin N. Shukla,Yili Wang,Guanjun Zhang,Yutaka Kawakami,Francesco M. Marincola,Paolo A. Ascierto,Daniel J. Sargent,Bernard A. Fox,Bernard A. Fox,Jérôme Galon,Jérôme Galon,Jérôme Galon +120 more
TL;DR: The immunoscore provides a reliable estimate of the risk of recurrence in patients with colon cancer and supports the implementation of the consensus Immunoscore as a new component of a TNM-Immune classification of cancer.
Journal ArticleDOI
Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer.
Bernhard Mlecnik,Carlo Bifulco,Gabriela Bindea,Gabriela Bindea,Florence Marliot,Alessandro Lugli,J. Jack Lee,Inti Zlobec,Tilman T. Rau,Martin D. Berger,Iris D. Nagtegaal,Elisa Vink-Börger,Arndt Hartmann,Carol Geppert,Julie Kolwelter,Susanne Merkel,Robert Grützmann,Marc Van den Eynde,Anne Jouret-Mourin,Alex Kartheuser,Daniel Léonard,Christophe Remue,Julia Y. Wang,Julia Y. Wang,Prashant Bavi,Michael H.A. Roehrl,Michael H.A. Roehrl,Michael H.A. Roehrl,Pamela S. Ohashi,Linh T. Nguyen,SeongJun Han,Heather L. MacGregor,Sara Hafezi-Bakhtiari,Bradly G. Wouters,Giuseppe Masucci,Emilia Andersson,Eva Zavadova,Michal Vocka,Jan Spacek,Lubos Petruzelka,Bohuslav Konopasek,Pavel Dundr,Helena Skalova,Kristyna Nemejcova,Gerardo Botti,Fabiana Tatangelo,Paolo Delrio,Gennaro Ciliberto,Michele Maio,Luigi Laghi,Fabio Grizzi,Tessa Fredriksen,Tessa Fredriksen,Bénédicte Buttard,Bénédicte Buttard,Lucie Lafontaine,Lucie Lafontaine,Daniela Bruni,Daniela Bruni,Anastasia Lanzi,Anastasia Lanzi,Carine El Sissy,Nacilla Haicheur,Amos Kirilovsky,Anne Berger,Christine Lagorce,Christopher Paustian,Carmen Ballesteros-Merino,Jeroen R. Dijkstra,Carlijn van de Water,Shannon van Lent–van Vliet,Nikki Knijn,Ana-Maria Muşină,Dragos-Viorel Scripcariu,Boryana Popivanova,Mingli Xu,Tomonobu Fujita,Shoichi Hazama,Nobuaki Suzuki,Hiroaki Nagano,Kiyotaka Okuno,Toshihiko Torigoe,Noriyuki Sato,Tomohisa Furuhata,Ichiro Takemasa,Kyogo Itoh,P. Patel,Hemangini H. Vora,Birva Shah,Jayendrakumar B. Patel,Kruti N. Rajvik,Shashank J. Pandya,Shilin N. Shukla,Yili Wang,Guanjun Zhang,Yutaka Kawakami,Francesco M. Marincola,Paolo A. Ascierto,Bernard A. Fox,Franck Pagès,Jérôme Galon,Jérôme Galon +101 more
TL;DR: It is suggested that patients with a high Immunoscore will benefit the most from chemotherapy in terms of recurrence risk, as well as the effect of chemotherapy on time to recurrence (TTR).
Journal ArticleDOI
Improvement of cancer immunotherapy by combining molecular targeted therapy.
Yutaka Kawakami,Tomonori Yaguchi,Hidetoshi Sumimoto,Chie Kudo-Saito,Tomoko Iwata-Kajihara,Shoko Nakamura,Takahiro Tsujikawa,Jeong Hoon Park,Boryana Popivanova,Junichiro Miyazaki,Naoshi Kawamura +10 more
TL;DR: Since common signaling pathways are involved in manifestation of several hallmarks of cancer, including cancer cell proliferation/survival, invasion/metastasis, and immunosuppression, targeting these shared signaling pathways in combination with immunotherapy may be a promising strategy for cancer treatment.
Book ChapterDOI
Development of Personalized Combination Cancer Immunotherapy Based on the Patients’ Immune Status
Yutaka Kawakami,Li Qian,Naoshi Kawamura,Junichiro Miyazaki,Haruna Nagumo,Kinya Tsubota,Tomonari Kinoshita,Kenta Nakamua,Gaku Ohmura,Ryosuke Satomi,Juri Sugiyama,Hiroshi Nishio,Taeko Hayakawa,Boryana Popivanova,Sunthamala Nuchsupha,Tracy Hsin-ju Liu,Hajime Kamijuku,Chie Kudo-Saito,Nobuo Tsukamoto,Toshiharu Sakurai,Tomonobu Fujita,Tomonori Yaguchi +21 more
TL;DR: Balance of anti-tumor T cell induction pathway and immunosuppressive pathway, which are regulated by characteristics of both cancer cells and patients’ immune reactivity, may define the differential immune status among cancer patients along with environmental factors such as intestinal microbiota.
Book ChapterDOI
Cancer Induced Immunosuppression and Its Modulation by Signal Inhibitors
Yutaka Kawakami,Li Qian,Naoshi Kawamura,Junichiro Miyazaki,Kinya Tsubota,Tomonari Kinoshita,Kenta Nakamura,Gaku Ohmura,Ryosuke Satomi,Juri Sugiyama,Hiroshi Nishio,Taeko Hayakawa,Boryana Popivanova,Sunthamala Nuchsupha,Tracy Hsin-ju Liu,Hajime Kamijuku,Chie Kudo-Saito,Nobuo Tsukamoto,Toshiharu Sakurai,Tomonobu Fujita,Tomonori Yaguchi +20 more
TL;DR: Since the oncogene-signal activation status is different among patients, personalized immunotherapy combined with appropriate signal inhibitors may be considered for the development of effective immunotherapy.