Jonathan Warrell

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: This work integrated genotypes and RNA sequencing in brain samples from 1695 individuals with autism spectrum disorder, schizophrenia, and bipolar disorder, as well as controls to identify causal drivers and define a mechanistic basis for the composite activity of genetic risk variants.

TL;DR: The resource and integrative analyses have uncovered genomic elements and networks in the brain, which in turn have provided insight into the molecular mechanisms underlying psychiatric disorders.

TL;DR: A novel method to decompose an image into large scale perceptually homogeneous elements for efficient salient region detection, using a soft image abstraction representation, which outperforms 18 alternate methods and is computationally more efficient.

TL;DR: A novel algorithm is proposed that produces superpixels that are forced to conform to a grid (a regular superpixel lattice) despite this added topological constraint, which is comparable in terms of speed and accuracy to alternative segmentation approaches.