K
Kui Li
Researcher at Civil Aviation Authority of Singapore
Publications - 21
Citations - 3127
Kui Li is an academic researcher from Civil Aviation Authority of Singapore. The author has contributed to research in topics: Population & Gene. The author has an hindex of 10, co-authored 18 publications receiving 2634 citations. Previous affiliations of Kui Li include Chinese Academy of Sciences & Beijing Institute of Genomics.
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Journal ArticleDOI
Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude
Xin Yi,Yu Liang,Emilia Huerta-Sanchez,Xin Jin,Zha Xi Ping Cuo,John E. Pool,John E. Pool,Xun Xu,Hui Jiang,Nicolas Vinckenbosch,Thorfinn Sand Korneliussen,Hancheng Zheng,Tao Liu,Weiming He,Kui Li,Ruibang Luo,Xifang Nie,Honglong Wu,Meiru Zhao,Hongzhi Cao,Jing Zou,Ying Shan,Shuzheng Li,Qi Yang,Asan,Peixiang Ni,Geng Tian,Junming Xu,Xiao Liu,Tao Jiang,Renhua Wu,Guangyu Zhou,Meifang Tang,Junjie Qin,Tong Wang,Shuijian Feng,Guohong Li,Huasang,Jiangbai Luosang,Wei Wang,Fang Chen,Yading Wang,Xiaoguang Zheng,Zhuo Li,Zhuoma Bianba,Ge Yang,Xiznping Wang,Shuhui Tang,Guoyi Gao,Yong Chen,Zhen Luo,Lamu Gusang,Zheng Cao,Qinghui Zhang,Wei-Han OuYang,Xiaoli Ren,Huiqing Liang,Huisong Zheng,Yebo Huang,Jingxiang Li,Lars Bolund,Karsten Kristiansen,Yingrui Li,Yong Zhang,Xiuqing Zhang,Ruiqiang Li,Songgang Li,Huanming Yang,Rasmus Nielsen,Rasmus Nielsen,Jun Wang,Jing Wang +71 more
TL;DR: A population genomic survey has revealed a functionally important locus in genetic adaptation to high altitude, and the strongest signal of natural selection came from endothelial Per-Arnt-Sim domain protein 1 (EPAS1), a transcription factor involved in response to hypoxia.
Journal ArticleDOI
Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA
Emilia Huerta-Sanchez,Xin Jin,Asan,Zhuoma Bianba,Benjamin M. Peter,Nicolas Vinckenbosch,Yu Liang,Xin Yi,Mingze He,Mehmet Somel,Peixiang Ni,Bo Wang,Xiaohua Ou,Huasang,Jiangbai Luosang,Zha Xi Ping Cuo,Kui Li,Guoyi Gao,Ye Yin,Wei Wang,Xiuqing Zhang,Xun Xu,Huanming Yang,Yingrui Li,Jian Wang,Jun Wang,Rasmus Nielsen +26 more
TL;DR: Re-sequencing the region around EPAS1 in 40 Tibetan and 40 Han individuals finds that this gene has a highly unusual haplotype structure that can only be convincingly explained by introgression of DNA from Denisovan or Denisovan-related individuals into humans.
Journal ArticleDOI
Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars
Mingzhou Li,Shilin Tian,Long Jin,Guangyu Zhou,Ying Li,Yuan Zhang,Tao Wang,Carol K.L. Yeung,Lei Chen,Jideng Ma,Jinbo Zhang,Anan Jiang,Ji Li,Chaowei Zhou,Jie Zhang,Yingkai Liu,Xiaoqing Sun,Hongwei Zhao,Zexiong Niu,Pinger Lou,Lingjin Xian,Xiaoyong Shen,Shaoqing Liu,Shunhua Zhang,Mingwang Zhang,Li Zhu,Surong Shuai,Lin Bai,Guoqing Tang,Haifeng Liu,Yanzhi Jiang,Miaomiao Mai,Jian Xiao,Xun Wang,Qi Zhou,Zhiquan Wang,Paul Stothard,Ming Xue,Xiaolian Gao,Zonggang Luo,Yiren Gu,Hongmei Zhu,Xiaoxiang Hu,Yaofeng Zhao,Graham Plastow,Jinyong Wang,Zhi Jiang,Kui Li,Ning Li,Xuewei Li,Ruiqiang Li +50 more
TL;DR: Comparing the genome of Tibetan wild boars with those of neighboring Chinese domestic pigs further showed the impact of thousands of years of artificial selection and different signatures of selection in wild boar and domestic pig.
Journal ArticleDOI
An atlas of DNA methylomes in porcine adipose and muscle tissues
Mingzhou Li,Honglong Wu,Zonggang Luo,Zonggang Luo,Yudong Xia,Jiuqiang Guan,Tao Wang,Yiren Gu,Lei Chen,Kai Zhang,Jideng Ma,Yingkai Liu,Zhijun Zhong,Jing Nie,Shuling Zhou,Zhiping Mu,Xiaoyan Wang,Jingjing Qu,Long Jing,Huiyu Wang,Shujia Huang,Na Yi,Zhe Wang,Dongxing Xi,Juan Wang,Guangliang Yin,Li Wang,Ning Li,Zhi Jiang,Qiulei Lang,Huasheng Xiao,Anan Jiang,Li Zhu,Yanzhi Jiang,Guoqing Tang,Miaomiao Mai,Surong Shuai,Kui Li,Jinyong Wang,Xiuqing Zhang,Yingrui Li,Haosi Chen,Xiaolian Gao,Graham Plastow,Stephen Beck,Huanming Yang,Jian Wang,Jun Wang,Xuewei Li,Ruiqiang Li +49 more
TL;DR: This comprehensive map provides a solid basis for exploring the epigenetic mechanisms of adipose deposition and muscle growth in pig as a model and identifies the differentially methylated regions in promoters.
Journal ArticleDOI
Repertoire of Porcine MicroRNAs in Adult Ovary and Testis by Deep Sequencing
Mingzhou Li,Yingkai Liu,Tao Wang,Jiuqiang Guan,Zonggang Luo,Haosi Chen,Xin-Xin Wang,Lei Chen,Jideng Ma,Zhiping Mu,Anan Jiang,Li-li Zhu,Qiulei Lang,Xiaochuan Zhou,Jinyong Wang,Wenxian Zeng,Ning Li,Kui Li,Xiaolian Gao,Xuewei Li +19 more
TL;DR: The present study characterizes the miRNA transcriptome of adult porcine gonads, with an emphasis on the co-expression patterns of X-linked miRNAs, to facilitate studies of the organ-specific reproductive roles of mi RNAs.