S
Sofia Nordling
Researcher at Stanford University
Publications - 7
Citations - 239
Sofia Nordling is an academic researcher from Stanford University. The author has contributed to research in topics: Lymph node & Lymphatic system. The author has an hindex of 4, co-authored 7 publications receiving 95 citations. Previous affiliations of Sofia Nordling include Uppsala University & Veterans Health Administration.
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Journal ArticleDOI
Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss
Maarja Andaloussi Mäe,Liqun He,Liqun He,Sofia Nordling,Sofia Nordling,Elisa Vazquez-Liebanas,Khayrun Nahar,Bongnam Jung,Xidan Li,Bryan C. Tan,Juat Chin Foo,Amaury Cazenave-Gassiot,Markus R. Wenk,Yvette Zarb,Bàrbara Laviña,Susan E. Quaggin,Marie Jeansson,Marie Jeansson,Chengua Gu,David L. Silver,Michael Vanlandewijck,Michael Vanlandewijck,Eugene C. Butcher,Annika Keller,Christer Betsholtz,Christer Betsholtz +25 more
TL;DR: In this article, pericytes are described as capillary mural cells playing a role in stabilizing newly formed blood vessels during development and tissue repair, and loss of pericyte has been described in several brain d...
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A molecular map of murine lymph node blood vascular endothelium at single cell resolution
Kevin Brulois,Anusha Rajaraman,Anusha Rajaraman,Agata Szade,Agata Szade,Sofia Nordling,Ania Bogoslowski,Denis Dermadi,Milladur Rahman,Helena Kiefel,Edward O'Hara,Jasper J. Koning,Hiroto Kawashima,Bin Zhou,Dietmar Vestweber,Kristy Red-Horse,Reina E. Mebius,Ralf H. Adams,Paul Kubes,Junliang Pan,Eugene C. Butcher,Eugene C. Butcher +21 more
TL;DR: The authors profile murine BECs from peripheral lymph nodes by single cell analysis and identify subsets of cells specialised for immune cell recruitment and vascular homeostasis, including a medullary venous population whose gene signature predicts a selective role in myeloid cell (vs lymphocyte) recruitment to the medulla.
Journal ArticleDOI
A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature.
Menglan Xiang,Menglan Xiang,Rubén Adrián Grosso,Akira Takeda,Junliang Pan,Tove Bekkhus,Kevin Brulois,Denis Dermadi,Sofia Nordling,Sofia Nordling,Michael Vanlandewijck,Michael Vanlandewijck,Sirpa Jalkanen,Maria H. Ulvmar,Eugene C. Butcher,Eugene C. Butcher +15 more
TL;DR: In this paper, a single-cell analysis of mouse lymph node (LN) lymphatic endothelial cells (LEC) at singlecell resolution is presented, which reveals a conserved cross-species pattern of lymphatic vascular niches and gene expression, as well as specialized human subsets and genes unique to each species.
Posted ContentDOI
A single-cell transcriptional roadmap of the mouse and human lymph node lymphatic vasculature
Menglan Xiang,Rubén Adrián Grosso,Akira Takeda,Junliang Pan,Tove Bekkhus,Kevin Brulois,Denis Dermadi,Sofia Nordling,Michael Vanlandewijck,Sirpa Jalkanen,Maria H. Ulvmar,Eugene C. Butcher +11 more
TL;DR: Computational alignments predict LN LEC organization in situ, revealing a continuum of phenotypes punctuated by specialized clusters Multiple intermediate phenotypes suggest LEC malleability Gene profiles define niche-specific functional specialization in Medullary sinus LECs.
Journal ArticleDOI
Retinoic Acid Promotes Endothelial Cell Cycle Early G1 State to Enable Human Hemogenic Endothelial Cell Specification.
TL;DR: It is demonstrated that RA treatment significantly increases human hemogenic endothelial cell specification, and insights provide guidance for the ex vivo generation of autologous human hemogen endothelial cells that are needed to produce human HSPCs for regenerative medicine applications.