S
Stefano Lise
Researcher at Institute of Cancer Research
Publications - 63
Citations - 2956
Stefano Lise is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Cancer & Exome sequencing. The author has an hindex of 25, co-authored 58 publications receiving 2529 citations. Previous affiliations of Stefano Lise include International School for Advanced Studies & University College London.
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Journal ArticleDOI
Factors influencing success of clinical genome sequencing across a broad spectrum of disorders
Jenny C. Taylor,Jenny C. Taylor,Hilary C. Martin,Stefano Lise,John Broxholme,Jean-Baptiste Cazier,Andrew J. Rimmer,Alexander Kanapin,Gerton Lunter,Simon Fiddy,Chris Allan,A. Radu Aricescu,Moustafa Attar,Christian Babbs,Jennifer Becq,David Beeson,Celeste Bento,P Bignell,Edward Blair,Veronica J. Buckle,Katherine R. Bull,Katherine R. Bull,Ondrej Cais,Holger Cario,Helen Chapel,Richard R. Copley,Richard R. Copley,Richard J. Cornall,Jude Craft,Jude Craft,Karin Dahan,Emma E. Davenport,Calliope A. Dendrou,Olivier Devuyst,Aimee L. Fenwick,Jonathan Flint,Lars Fugger,Rodney D. Gilbert,Anne Goriely,Angie Green,Ingo H. Greger,Russell J. Grocock,Anja V. Gruszczyk,Robert W. Hastings,Edouard Hatton,Doug Higgs,Adrian V. S. Hill,Adrian V. S. Hill,Christopher Holmes,Christopher Holmes,Malcolm F. Howard,Malcolm F. Howard,Linda Hughes,Peter Humburg,David W. Johnson,Fredrik Karpe,Zoya Kingsbury,Usha Kini,Julian C. Knight,Jon P. Krohn,Sarah Lamble,Craig B. Langman,Lorne Lonie,Joshua Luck,Davis J. McCarthy,Simon J. McGowan,Mary Frances McMullin,Kerry A. Miller,Lisa Murray,Andrea H. Németh,M. Andrew Nesbit,David J. Nutt,Elizabeth Ormondroyd,Annette Bang Oturai,Alistair T. Pagnamenta,Alistair T. Pagnamenta,Smita Y. Patel,Melanie J. Percy,Nayia Petousi,Paolo Piazza,Sian E. Piret,Guadalupe Polanco-Echeverry,Niko Popitsch,Niko Popitsch,Fiona Powrie,Christopher W. Pugh,Lynn Quek,Peter A. Robbins,Kathryn J. H. Robson,Alexandra Russo,Natasha Sahgal,Pauline A. van Schouwenburg,Anna Schuh,Anna Schuh,Earl D. Silverman,Alison Simmons,Per Soelberg Sørensen,Elizabeth Sweeney,John Taylor,John Taylor,Rajesh V. Thakker,Ian Tomlinson,Ian Tomlinson,Amy Trebes,Stephen R.F. Twigg,Holm H. Uhlig,Paresh Vyas,Timothy J. Vyse,Steven A. Wall,Hugh Watkins,Michael P. Whyte,Lorna Witty,Ben Wright,Christopher Yau,David Buck,Sean Humphray,Peter J. Ratcliffe,John I. Bell,Andrew O.M. Wilkie,David Bentley,Peter Donnelly,Peter Donnelly,Gilean McVean +122 more
TL;DR: It is found that jointly calling variants across samples, filtering against both local and external databases, deploying multiple annotation tools and using familial transmission above biological plausibility contributed to accuracy.
Journal ArticleDOI
The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis
Frances M. G. Pearl,Annabel E. Todd,Ian Sillitoe,Mark Dibley,Oliver C. Redfern,Tony E. Lewis,Christopher G. Bennett,Russell L. Marsden,Alastair Grant,David A. Lee,Adrian Akpor,Michael Maibaum,Andrew Harrison,Timothy J. Dallman,Gabrielle A. Reeves,Ilhem Diboun,Sarah Addou,Stefano Lise,Caroline Johnston,Antonio Sillero,Janet M. Thornton,Christine A. Orengo +21 more
TL;DR: The CATH database of protein domain structures currently contains 43 229 domains classified into 1467 superfamilies and 5107 sequence families is expanded with sequence relatives from GenBank and completed genomes, using a variety of efficient sequence search protocols and reliable thresholds.
Journal ArticleDOI
Universal fluctuations in correlated systems
Steven T. Bramwell,Kim Christensen,Jean-Yves Fortin,Peter C. W. Holdsworth,Henrik Jeldtoft Jensen,Stefano Lise,Juan M. López,Mario Nicodemi,Jean-François Pinton,M. Sellitto +9 more
TL;DR: It is demonstrated that this function describes the fluctuations of global quantities in other correlated equilibrium and nonequilibrium systems, including a coupled rotor model, Ising and percolation models, models of forest fires, sandpiles, avalanches, and granular media in a self-organized critical state.
Journal ArticleDOI
PepSite: prediction of peptide-binding sites from protein surfaces
TL;DR: An updated version of the PepSite web server is presented that is orders of magnitude faster than the original implementation, returning results in seconds instead of minutes or hours, and relies on preferred peptide-binding environments calculated from a set of known protein–peptide 3D structures.
Journal ArticleDOI
Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer
Andrew Woolston,Khurum Khan,Georgia Spain,Louise J. Barber,Beatrice Griffiths,Reyes Gonzalez Exposito,Lisa Hornsteiner,Marco Punta,Yatish Patil,Alice Newey,Sonia Mansukhani,Matthew N. Davies,Andrew Furness,Francesco Sclafani,Clare Peckitt,Mirta Jiménez,Kyriakos Kouvelakis,Romana Ranftl,Ruwaida Begum,Isma Rana,Janet Thomas,Annette Bryant,Sergio A. Quezada,Andrew Wotherspoon,Nasir Khan,N. Fotiadis,Teresa Marafioti,Thomas Powles,Stefano Lise,Fernando Calvo,Sebastian Guettler,Katharina von Loga,Sheela Rao,David Watkins,Naureen Starling,Ian Chau,Anguraj Sadanandam,David Cunningham,Marco Gerlinger,Marco Gerlinger +39 more
TL;DR: This genomic and transcriptomic analysis of the cetuximab resistance landscape in 35 RAS wild-type CRCs identified associations of NF1 and non-canonical RAS/RAF aberrations with primary resistance and validated transcriptomic CRC subtypes as non-genetic predictors of benefit.