Stephan Schreiber

TL;DR: The largest genotype association study, to date, in widely used clinical subphenotypes of inflammatory bowel disease with the goal of further understanding the biological relations between diseases.

TL;DR: The COMorbidities among the five immune diseases were best explained by biological pleiotropy rather than heterogeneity (a subgroup of cases genetically identical to those with another disease, possibly owing to diagnostic misclassification, molecular subtypes or excessive comorbidity), and the strong comor bid between primary sclerosing cholangitis and inflammatory bowel disease is likely the result of a unique disease.

TL;DR: The IBD International Genetics Consortium replicated the IBD4 locus on chromosome 14q for CD and showed evidence for a gene‐environment interaction at this locus, and further studies are needed to explore the mechanism by which smoking influences IBD 4.

TL;DR: A strictly anaerobic, Gram-positive, short-rod/coccobacillus-shaped bacterial strain was isolated from the colon of a patient suffering from acute Crohn's disease and revealed that the isolate represents a distinct lineage within the family Coriobacteriaceae and has 94.6 % identity to the type strain of [Eggerthella] hongkongensis, the phylogenetically closest bacterial species.

TL;DR: It is demonstrated that a short-term rehabilitation program with moderate exercise leads to a decreased LPS-induced antagonist response with a shift to a more pro-inflammatory state (decreased antagonist/cytokine ratio) in patients with curatively treated colorectal cancer.