S
Susan L. Smalley
Researcher at Semel Institute for Neuroscience and Human Behavior
Publications - 6
Citations - 720
Susan L. Smalley is an academic researcher from Semel Institute for Neuroscience and Human Behavior. The author has contributed to research in topics: Attention deficit hyperactivity disorder & Population. The author has an hindex of 6, co-authored 6 publications receiving 640 citations. Previous affiliations of Susan L. Smalley include University of California, Los Angeles & University of California, Berkeley.
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Journal ArticleDOI
Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder
Josephine Elia,Joseph T. Glessner,Kai Wang,Nagahide Takahashi,Corina Shtir,Dexter Hadley,Patrick M. A. Sleiman,Haitao Zhang,Cecilia E. Kim,Reid J. Robison,Gholson J. Lyon,James H. Flory,Jonathan P. Bradfield,Marcin Imielinski,Cuiping Hou,Edward C. Frackelton,Rosetta M. Chiavacci,Takeshi Sakurai,Cara R. Rabin,Frank A. Middleton,Kelly A. Thomas,Maria Garris,Frank D. Mentch,Christine M. Freitag,Hans-Christoph Steinhausen,Hans-Christoph Steinhausen,Hans-Christoph Steinhausen,Alexandre A. Todorov,Andreas Reif,Aribert Rothenberger,Barbara Franke,Eric Mick,Herbert Roeyers,Jan K. Buitelaar,Klaus-Peter Lesch,Tobias Banaschewski,Richard P. Ebstein,Fernando Mulas,Robert D. Oades,Joseph A. Sergeant,Edmund J.S. Sonuga-Barke,Edmund J.S. Sonuga-Barke,Edmund J.S. Sonuga-Barke,Tobias J. Renner,Marcel Romanos,Jasmin Romanos,Andreas Warnke,Susanne Walitza,Susanne Walitza,Jobst Meyer,Haukur Palmason,Christiane Seitz,Sandra K. Loo,Susan L. Smalley,Joseph Biederman,Lindsey Kent,Philip Asherson,Richard Anney,J. William Gaynor,Philip Shaw,Marcella Devoto,Peter White,Struan F.A. Grant,Struan F.A. Grant,Joseph D. Buxbaum,Judith L. Rapoport,Nigel Williams,Stanley F. Nelson,Stephen V. Faraone,Hakon Hakonarson +69 more
TL;DR: A gene network analysis showed that genes interacting with the genes in the GRM family are enriched for CNVs in ∼10% of the cases, and rare recurrent CNVs affecting glutamatergic neurotransmission genes that were overrepresented in multiple ADHD cohorts were identified.
Journal ArticleDOI
Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3
Nigel Williams,Barbara Franke,Eric Mick,Richard Anney,Christine M. Freitag,Michael Gill,Anita Thapar,Michael Conlon O'Donovan,Michael John Owen,Peter Holmans,Lindsey Kent,Frank A. Middleton,Yanli Zhang-James,Lu Liu,Jobst Meyer,Thuy Trang Nguyen,Jasmin Romanos,Marcel Romanos,Christiane Seitz,Tobias J. Renner,Susanne Walitza,Andreas Warnke,Haukur Palmason,Jan K. Buitelaar,Nanda Rommelse,Alejandro Arias Vasquez,Ziarih Hawi,Kate Langley,Joseph A. Sergeant,Hans-Christoph Steinhausen,Herbert Roeyers,Joseph Biederman,Irina Takova Zaharieva,Hakon Hakonarson,Josephine Elia,Anath C. Lionel,Jennifer Crosbie,Christian R. Marshall,Russell Schachar,Stephen W. Scherer,Alexander A Todorov,Susan L. Smalley,Sandra K. Loo,Stanley F. Nelson,Corina Shtir,Philip Asherson,Andreas Reif,Klaus-Peter Lesch,Stephen V. Faraone +48 more
TL;DR: Findings support the enrichment of large, rare CNVs in ADHD and implicate duplications at 15q13.3 as a novel risk factor for ADHD.
Journal ArticleDOI
Genome-Wide Association Study of the Child Behavior Checklist Dysregulation Profile
Eric Mick,James J. McGough,Sandra K. Loo,Alysa E. Doyle,Janet Wozniak,Timothy E. Wilens,Susan L. Smalley,James T. McCracken,Joseph Biederman,Stephen V. Faraone +9 more
TL;DR: A genome-wide association study of the Child Behavior Checklist profile, comprising the Attention Problems, Anxious/Depressed, and Aggressive Behavior clinical subscales, in children with attention-deficit/hyperactivity disorder (ADHD) found suggestive evidence for developmentally expressed genes operant in hippocampal dependent memory and learning with the CBCL-DP.
Journal ArticleDOI
Genome-wide association study of intelligence: additive effects of novel brain expressed genes.
Sandra K. Loo,Corina Shtir,Alysa E. Doyle,Eric Mick,James J. McGough,James T. McCracken,Joseph Biederman,Susan L. Smalley,Rita M. Cantor,Stephen V. Faraone,Stanley F. Nelson +10 more
TL;DR: The results describe novel variants and additive effects of genes involved in brain development on variability in intelligence within an ADHD sample and the precise mechanisms of these loci in relation to determining individual differences in general cognitive ability require further investigation.
Journal ArticleDOI
Sex-specific influence of DRD2 on ADHD-type temperament in a large population-based birth cohort.
Emma S. Nyman,Anu Loukola,Teppo Varilo,Anja Taanila,Tuula Hurtig,Irma Moilanen,Sandra K. Loo,James J. McGough,Marjo-Riitta Järvelin,Susan L. Smalley,Stanley F. Nelson,Leena Peltonen +11 more
TL;DR: This paper reported an association of DRD2 with low persistence in females (rs1079727 P = 0.02, rs1124491 P=0.03, rs1800497 P= 0.03), the same haplotype associated with ADHD in males in this birth cohort.