S
Susumu Tonegawa
Researcher at Massachusetts Institute of Technology
Publications - 419
Citations - 85400
Susumu Tonegawa is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & T-cell receptor. The author has an hindex of 150, co-authored 416 publications receiving 79814 citations. Previous affiliations of Susumu Tonegawa include University of Zurich & RIKEN Brain Science Institute.
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Journal ArticleDOI
Ordered rearrangement of immunoglobulin heavy chain variable region segments.
Frederick W. Alt,George D. Yancopoulos,T K Blackwell,Charles E. Wood,Elise Thomas,Michael Alan Boss,Robert L. Coffman,Naomi Rosenberg,Susumu Tonegawa,David Baltimore +9 more
TL;DR: Results support an ordered mechanism of variable gene assembly during B‐cell differentiation in which D‐to‐JH rearrangements generally occur first and on both chromosomes followed by VH‐to-DJH rearranged, with both types of joining processes occurring by intrachromosomal deletion.
Journal ArticleDOI
Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKCγ
Annika B. Malmberg,Chong Chen,Chong Chen,Susumu Tonegawa,Susumu Tonegawa,Allan I. Basbaum,Allan I. Basbaum +6 more
TL;DR: Mice that lack protein kinase C gamma displayed normal responses to acute pain stimuli, but they almost completely failed to develop a neuropathic pain syndrome after partial sciatic nerve section, and the neurochemical changes that occurred in the spinal cord after nerve injury were blunted.
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Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
TL;DR: Two types of somatic recombination are necessary for the generation of a complete immunoglobulin γ2b gene from germ-line DNA sequences and DNA sequencing studies suggest that the two types of recombination operate by different mechanisms.
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Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions
Nobumichi Hozumi,Susumu Tonegawa +1 more
TL;DR: The results were interpreted to mean that the Vk and Ck genes are joined to form a contiguous polynucleotide stretch during differentiation of lymphocytes, which occurs in both of the homologous chromosomes.
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B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo
TL;DR: There are changes in the reactivity of guanine residues to dimethyl sulfate within the enhancer sequence in myeloma, B, and early B cells, whereas virtually no alterations appear in cells of non-B lineage.