S
Susumu Tonegawa
Researcher at Massachusetts Institute of Technology
Publications - 419
Citations - 85400
Susumu Tonegawa is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & T-cell receptor. The author has an hindex of 150, co-authored 416 publications receiving 79814 citations. Previous affiliations of Susumu Tonegawa include University of Zurich & RIKEN Brain Science Institute.
Papers
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Journal ArticleDOI
Expression of cloned immunoglobulin genes introduced into mouse L cells.
S D Gilles,Susumu Tonegawa +1 more
TL;DR: The results suggest that the expression of rearranged heavy-chain and light-chain genes are controlled differently and that these differences can be seen in transfected, non-lymphoid cells.
Journal ArticleDOI
Differentiation of forebrain and hippocampal dopamine 1‐class receptors, D1R and D5R, in spatial learning and memory
TL;DR: The data provide evidence that forebrain D5R activation plays a unique role in spatial learning and memory in conjunction with D1R activation, and suggest that mPFC and striatal, but not DG D1r activation are essential for spatiallearning and memory.
Journal ArticleDOI
Antibody and T-cell receptors.
TL;DR: A VERTEBRATE is an attractive culture medium for viruses, bacteria, fungi, and metazoan parasites, it is therefore understandable that vertebrates have had to develop a body defense mechanism directed toward these pathogens for their emergence and survival.
Journal Article
Distribution of thymocytes expressing gamma delta receptors in the murine thymus during development.
TL;DR: Ulastructural immunohistochemistry confirmed the close association between medullary thymic epithelial cells and gamma delta+ thymocytes in the neonatal thymus and also showed that some TCR-gamma delta molecules were patched to areas of contact with medullARY epithelial Cells.
Book
The Network Collective: Rise and Fall of a Scientific Paradigm
Klaus Eichmann,Oswald T. Avery,David Baltimore,Emil Von Behring,Baruj Benacerraf,David Bloor,Jules J.B.V. Bordet,Constantin Bona,Edward A. Boyse,F. Macfarlane Burnet,Harvey Cantor,Pierre André Cazenave,Henry N. Claman,Melvin Cohn,Antonio Coutinho,Mark M. Davis,Francis H. Crick,Theodosius G. Dobzhansky,Peter C. Doherty,Umberto Eco,Gerald M. Edelman,Paul Ehrlich,Paul Feyerabend,Ludwik Fleck,Joan Fujimura,Richard K. Gershon,Ronald N. Germain,James L. Gowans,Mark I. Greene,Ian Hacking,Felix Haurowitz,Pekka Häyry,Michael Heidelberger,Leonard N. Herzenberg,Norbert Hilschmann,Geoffrey W. Hoffmann,Leroy Hood,Kurt Hübner,David A. Hume,Charles A. Janeway,Cristina Joao,Niels K. Jerne,Elvin A. Kabat,Michel D. Kazatchkine,Shibasaburo Kitasato,Karin Knorr-Cetina,Georges Köhler,Heinz Kohler,Hilary Koprowski,Thomas S. Kuhn,Henry G. Kunkel,Imre Lakatos,Karl Landsteiner,Bruno Latour,Larry Laudan,Joshua Lederberg,Ronald Levy,Tak W. Mak,Philippa Marrack,John J. Marchalonis,Polly Matzinger,Hugh O. McDevitt,Peter Medawar,Jaques F.A. Miller,Cesar Milstein,N. Avrion Mitchison,Göran Möller,Alfred Nisonoff,Gustav J. V. Nossal,Susumu Ohno,Jacques Oudin,William E. Paul,Linus Pauling,Karl Popper,Rodney R. Porter,Michael Potter,Willard V. O. Quine,Martin Raff,Klaus Rajewsky,Hans Reichenbach,Scott L. Rodkey,Michael Sela,Eli E. Sercarz,Morton Simonsen,Alan D. Sokal,Tomio Tada,David W. Talmage,Arne W. K. Tiselius,Susumu Tonegawa,Thure Von Uexküll,Emil R. Unanue,Jonathan W. Uhr,Jacques Urbain,Francisco J. Varela,Nelson M. Vaz,James D. Watson,Norbert Wiener,Hans Wigzell,Rolf M. Zinkernagel +98 more
TL;DR: A first-hand account of the rise and fall of a scientific paradigm shows how scientific fiction turns to fact and develops a general perspective on how solid knowledge is derived from error-prone scientific methodology, namely by exposure of scientific notions to the scrutiny of reality.