S
Susumu Tonegawa
Researcher at Massachusetts Institute of Technology
Publications - 419
Citations - 85400
Susumu Tonegawa is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & T-cell receptor. The author has an hindex of 150, co-authored 416 publications receiving 79814 citations. Previous affiliations of Susumu Tonegawa include University of Zurich & RIKEN Brain Science Institute.
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Journal ArticleDOI
The role of engram cells in the systems consolidation of memory.
TL;DR: The theory of system consolidation of memory (SCM) suggests that changes in circuitry and brain networks are required for the maintenance of a memory with time, and various mechanisms by which such changes may take place have been hypothesized as mentioned in this paper.
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Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta.
Antonio Bandeira,Shigeyoshi Itohara,Marc Bonneville,Odile Burlen-Defranoux,T Mota-Santos,Antonio Coutinho,Susumu Tonegawa +6 more
TL;DR: This work shows that a small pool of T cells carrying alpha beta T-cell receptors can also differentiate extrathymically from CD3- fetal liver precursors but with rates of production and peripheral expansion much reduced as compared with those observed in thymus-bearing animals.
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Alterations in Dopamine Release But Not Dopamine Autoreceptor Function in Dopamine D3 Receptor Mutant Mice
Timothy E Koeltzow,Ming Xu,Donald C. Cooper,Xiu-Ti Hu,Susumu Tonegawa,Marina E. Wolf,Francis J. White +6 more
TL;DR: The results suggest that the effects of PD 128907 on dopamine cell function reflect stimulation of D2 as opposed to D3 receptors, which may participate in postsynaptically activated short-loop feedback modulation of DA release.
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Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice.
David J. Gerber,Tatyana D. Sotnikova,Raul R. Gainetdinov,Shu Ying Huang,Marc G. Caron,Susumu Tonegawa +5 more
TL;DR: It is reported that M1 deficiency leads to elevated dopaminergic transmission in the striatum and significantly increased locomotor activity, consistent with the idea that M 1 dysfunction could be a contributing factor in psychiatric disorders in which altered dopamine transmission has been implicated.
Memory engram storage and retrieval
TL;DR: Memory engram technology allows the labeling and subsequent manipulation of components of specific memory engrams in particular brain regions, and it has been established that cell ensembles labeled by this method are both sufficient and necessary for memory recall.