S
Susumu Tonegawa
Researcher at Massachusetts Institute of Technology
Publications - 419
Citations - 85400
Susumu Tonegawa is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & T-cell receptor. The author has an hindex of 150, co-authored 416 publications receiving 79814 citations. Previous affiliations of Susumu Tonegawa include University of Zurich & RIKEN Brain Science Institute.
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Journal ArticleDOI
Tolerance Induction and Autoimmune Encephalomyelitis Amelioration After Administration of Myelin Basic Protein–derived Peptide
Suzana Marusic,Susumu Tonegawa +1 more
TL;DR: It is proposed that continuous encounters of MBP-specific T cells with p17 play a critical role in the induction and maintenance of tolerance, and seems to be based on reduction in the responsiveness of anti-MBP T cells.
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Blockage of αβ T-cell development by TCR γδ transgenes
Marc Bonneville,I Ishida,Peter Mombaerts,Motoya Katsuki,Sjef Verbeek,A Berns,Susumu Tonegawa +6 more
TL;DR: It is reported that the generation of a αβ T cells is severely blocked in transgenic mice carrying γ- and δ-chain transgenes without the associated silencer, thereby strengthening the validity of the silencer model of T-cell development.
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Entorhinal–hippocampal neuronal circuits bridge temporally discontiguous events
TL;DR: The evidence concerning the role of the EC in associating events separated by time--or temporal associative learning--with emphasis on the function of persistent activity in the medial entorhinal cortex layer III and their direct inputs into the CA1 region of HPC is examined.
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γδ T cells regulate mucosally induced tolerance in a dose-dependent fashion
Kohtaro Fujihashi,Taeko Dohi,Mi-Na Kweon,Jerry R. McGhee,Toshiya Koga,Max D. Cooper,Susumu Tonegawa,Hiroshi Kiyono +7 more
TL;DR: It is indicated that gammadelta T cells play a significant immunoregulatory role in IL-10-mediated, low-dose oral tolerance induction, but are not essential participants in the induction of systemic tolerance to orally introduced antigens given in larger doses.
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DNA sequences of the joining regions of mouse lambda light chain immunoglobulin genes
TL;DR: From the J4 sequence, it is concluded that the lambda 4 gene is most likely nonfunctional (i.e., a pseudogene), which could account in part for the lower level of expression of lambda 3 as compared with lambda 1 in mouse serum.