S
Susumu Tonegawa
Researcher at Massachusetts Institute of Technology
Publications - 419
Citations - 85400
Susumu Tonegawa is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & T-cell receptor. The author has an hindex of 150, co-authored 416 publications receiving 79814 citations. Previous affiliations of Susumu Tonegawa include University of Zurich & RIKEN Brain Science Institute.
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Journal ArticleDOI
Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes
Yoshikazu Kurosawa,Harald von Boehmer,Werner Haas,Hitoshi Sakano,André Trauneker,Susumu Tonegawa +5 more
TL;DR: The results support the 12/23-base pair model for somatic generation of immunoglobulin V genes, and rule out the possibility that the cytolytic T cells use assembled VH, D and JH sequences to encode their antigen receptors.
Journal ArticleDOI
What is memory? The present state of the engram
Mu-ming Poo,Michele Pignatelli,Tomás J. Ryan,Tomás J. Ryan,Susumu Tonegawa,Susumu Tonegawa,Tobias Bonhoeffer,Kelsey C. Martin,Andrii Rudenko,Li-Huei Tsai,Richard W. Tsien,Gord Fishell,Caitlin Mullins,J. Tiago Gonçalves,Matthew Shtrahman,Stephen T. Johnston,Fred H. Gage,Yang Dan,John D. Long,György Buzsáki,Charles F. Stevens +20 more
TL;DR: This Forum brings together leading contemporary views on the mechanisms of memory and what the engram means today.
Bidirectional switch of the valence associated with a hippocampal contextual memory engram
TL;DR: This article found that the neurons carrying the memory engram of a given neutral context have plasticity such that the valence of a conditioned response evoked by their reactivation can be reversed by re-associating this contextual memory embedding with a new unconditioned stimulus of an opposite valence.
Journal Article
Somatic generation of antibody diversity.
TL;DR: This paper showed that base sequence homology among lambda-mRNAs is so high that any lambda-RNAs should cross-hybridize with all or most of the germ line V lambda genes and concluded that the number of germ line genes is too small to account for the diversity of lambda chains.
Journal ArticleDOI
Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes
TL;DR: A putative diversity segment of immunoglobulin heavy-chain genes (D segment) has been identified 700 base pairs 5′ to JH1 DNA on the germ-line genome of the mouse and allelic exclusion is discussed with respect to D segments.