S
Susumu Tonegawa
Researcher at Massachusetts Institute of Technology
Publications - 419
Citations - 85400
Susumu Tonegawa is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & T-cell receptor. The author has an hindex of 150, co-authored 416 publications receiving 79814 citations. Previous affiliations of Susumu Tonegawa include University of Zurich & RIKEN Brain Science Institute.
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Journal ArticleDOI
Intermediates in the assembly of φX174
Susumu Tonegawa,Masaki Hayashi +1 more
TL;DR: Two φX174 specific precursor particles, 9 and 6 s, were found that can be formed during cell lysis and subsequent sucrose gradient centrifugation from E protein monomer and non-phage proteins existing in the cell and the significance of these particles in the early stages of φ X174 phage assembly is discussed.
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High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes.
Christiaan N. Levelt,Y.P. de Jong,Emiko Mizoguchi,Cliona O'Farrelly,Atul K. Bhan,Susumu Tonegawa,Cox Terhorst,Stephen J. Simpson +7 more
TL;DR: It is demonstrated that single ligands with a high or low affinity for TCR are capable of inducing or inhibiting the maturation of alternative subsets of IELs.
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Alteration of a polyclonal to an oligoclonal immune response to cecal aerobic bacterial antigens in TCRα mutant mice with inflammatory bowel disease
TL;DR: The unique population of CD4+ TCRalpha -beta + cells in TCR alpha -/- mice may be involved in the recognition of these bacterial antigens and the absence of the alpha chain may result in the alteration of immune response.
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Differences in the level of expression of class I major histocompatibility complex proteins on thymic epithelial and dendritic cells influence the decision of immature thymocytes between positive and negative selection
TL;DR: The results suggest that quantitative differences in the level of expression of class I MHC proteins on thymic epithelial and dendritic cells contribute to the opposing roles these cells play in forming the repertoire of mature classI MHC restricted (CD8+) T cells.
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Acceleration of visually cued conditioned fear through the auditory pathway.
TL;DR: The rewired auditory pathway conveys visual information and mediates rapid activity-dependent plasticity in central structures that influence learned behavior in 'rewired' mice that have retinal projections routed to the auditory thalamus.