S
Susumu Tonegawa
Researcher at Massachusetts Institute of Technology
Publications - 419
Citations - 85400
Susumu Tonegawa is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & T-cell receptor. The author has an hindex of 150, co-authored 416 publications receiving 79814 citations. Previous affiliations of Susumu Tonegawa include University of Zurich & RIKEN Brain Science Institute.
Papers
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Enhancement of Learning and Memory by Elevating Brain Magnesium
Inna Slutsky,Nashat Abumaria,Long Jun Wu,Chao Huang,Ling Zhang,Bo I. Li,Xiang Zhao,Arvind Govindarajan,Ming Gao Zhao,Min Zhuo,Susumu Tonegawa,Guosong Liu,Guosong Liu +12 more
TL;DR: In this paper, the authors show that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) leads to the enhancement of learning abilities, working memory, and short and long-term memory in rats.
Posted ContentDOI
Cingulate-motor circuits update rule representations for sequential choice decisions
Takeuchi D,Takeuchi D,Dheeraj S. Roy,Dheeraj S. Roy,Shruti Muralidhar,Kawai T,Lovett C,Heather A. Sullivan,Ian R. Wickersham,Susumu Tonegawa +9 more
TL;DR: In this article, the authors demonstrate that chemogenetic silencing of the projection terminals of cingulate cortical neurons in secondary motor cortex disrupted sequential choice performance in trials immediately following rule switches, suggesting that these inputs are necessary to update rule representations for choice decisions stored in the motor cortex.
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Biological Analyses for Characterization of the Uterine Sarcoma Using Mouse Model
Takuma Hayashi,Tomoyuki Ichimura,Mari Kasai,Yae Kanai,Hirofumi Ando,Koichi Ida,Nobuo Yaegashi,Susumu Tonegawa,Ikuo Konishi +8 more
TL;DR: Uterine sarcomas are neoplastic malignancies that typically arise in tissues of a mesenchymal origin in uterine body and the establishment of new therapies and biomarkers has been hampered by several critical factors.
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Proteasome LMP2/β1i subunit as biomarker for human uterine leiomyosarcoma
Takuma Hayashi,Akiko Horiuchi,Hiroyuki Aburatani,Osamu Ishiko,Nobuo Yaegashi,Yae Kanai,Dorit Zharhary,Susumu Tonegawa,Ikuo Konishi +8 more
TL;DR: It is shown that LMP2/b1i expression was absent in human Ut-LMS, but present in other human uterine mesenchymal tumors including uterine LMA, and may be a targeted molecule for a new therapeutic approach.