S
Susumu Tonegawa
Researcher at Massachusetts Institute of Technology
Publications - 419
Citations - 85400
Susumu Tonegawa is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & T-cell receptor. The author has an hindex of 150, co-authored 416 publications receiving 79814 citations. Previous affiliations of Susumu Tonegawa include University of Zurich & RIKEN Brain Science Institute.
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Journal ArticleDOI
Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion
Toshiaki Nakashiba,Jesse D. Cushman,Kenneth A. Pelkey,Sophie Renaudineau,Derek L. Buhl,Thomas J. McHugh,Vanessa Rodriguez Barrera,Ramesh Chittajallu,Keisuke S. Iwamoto,Chris J. McBain,Michael S. Fanselow,Susumu Tonegawa +11 more
TL;DR: It is suggested that as adult-born GCs age, their function switches from pattern separation to rapid pattern completion, and older GCs contribute to the rapid recall by pattern completion.
Journal ArticleDOI
Sequences at the somatic recombination sites of immunoglobulin light-chain genes.
TL;DR: This hypothetical structure and gel-blotting analysis of total embryo and myeloma DNA suggest that the somatic recombination may be accompanied by excision of an entire DNA segment between a V gene and a J DNA segment, which may generate antibody diversity by modulation of the precise recombination sites.
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Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice
Peter Mombaerts,Emiko Mizoguchi,Michael J. Grusby,Laurie H. Glimcher,Atul K. Bhan,Susumu Tonegawa +5 more
TL;DR: It is suggested that dysfunction of the mucosal immune system may underly the pathogenesis of some types of IBD in humans.
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Evidence for a differential avidity model of T cell selection in the thymus
Philip G. Ashton-Rickardt,Antonio Bandeira,Joseph R. Delaney,Luc Van Kaer,Hanspeter Pircher,Rolf M. Zinkernagel,Susumu Tonegawa +6 more
TL;DR: A critical parameter that controls the fate of a thymocyte seems to be the number of TCRs engaged with complexes of peptide and major histocompatibility complex and when this number is low, positive selection occurs, and when it is high, negative selection takes place.
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TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells.
Luc Van Kaer,Luc Van Kaer,Philip G. Ashton-Rickardt,Philip G. Ashton-Rickardt,Hidde L. Ploegh,Susumu Tonegawa,Susumu Tonegawa +6 more
TL;DR: Mice with a disrupted TAP1 gene are generated using embryonic stem cell technology and show severely reduced levels of surface class I molecules, strikingly similar to those described for the TAP2 mutant cell line RMA-S.