S
Susumu Tonegawa
Researcher at Massachusetts Institute of Technology
Publications - 419
Citations - 85400
Susumu Tonegawa is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & T-cell receptor. The author has an hindex of 150, co-authored 416 publications receiving 79814 citations. Previous affiliations of Susumu Tonegawa include University of Zurich & RIKEN Brain Science Institute.
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Lack of kainic acid-induced gamma oscillations predicts subsequent CA1 excitotoxic cell death.
Seiichiro Jinde,Juan E. Belforte,Juan E. Belforte,Jun Yamamoto,Matthew A. Wilson,Susumu Tonegawa,Kazu Nakazawa +6 more
TL;DR: In this paper, the authors assessed the relationship between kainic acid (KA)-induced gamma oscillations and excitotoxicity in genetically engineered mice in which N-methyl-D-aspartic acid receptor deletion was confined to CA3 pyramidal cells.
Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease
Dheeraj S. Roy,Autumn L. Arons,Teryn I. Mitchell,Michele Pignatelli di Spinazzola,Tomás J. Ryan,Susumu Tonegawa +5 more
TL;DR: It is shown that in transgenic mouse models of early AD, direct optogenetic activation of hippocampal memory engram cells results in memory retrieval despite the fact that these mice are amnesic in long-term memory tests when natural recall cues are used, revealing a retrieval, rather than a storage impairment.
Journal ArticleDOI
Competition from newborn granule cells does not drive axonal retraction of silenced old granule cells in the adult hippocampus.
Carla M. Lopez,Kenneth A. Pelkey,Ramesh Chittajallu,Toshiaki Nakashiba,Katalin Tóth,Susumu Tonegawa,Chris J. McBain +6 more
TL;DR: The data demonstrate a remarkable stability in the face of a relatively prolonged period of altered synaptic competition between two populations of neurons within the adult brain.
Journal ArticleDOI
Phorbol ester effects at hippocampal synapses act independently of the gamma isoform of PKC.
TL;DR: It is demonstrated that the gamma isotype of PKC is not essential for phorbol ester-mediated synaptic facilitation, and limitations on the possible roles ofPKC in LTP are placed.
Journal ArticleDOI
Hybridization studies with an antibody heavy chain mRNA.
A. Bernardini,Susumu Tonegawa +1 more
TL;DR: There are a very limited number possibly a single copy per subgroup of genes coding for the variable region of immunoglobulin polypeptides, and the results confirm and extend the previous finding that antibody diversity is generated in large part by somatic processes.