S
Susumu Tonegawa
Researcher at Massachusetts Institute of Technology
Publications - 419
Citations - 85400
Susumu Tonegawa is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & T-cell receptor. The author has an hindex of 150, co-authored 416 publications receiving 79814 citations. Previous affiliations of Susumu Tonegawa include University of Zurich & RIKEN Brain Science Institute.
Papers
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Patent
Methods and compositions for treating alzheimer's disease and other memory-associated disorders and conditions
Susumu Tonegawa,Dheeraj S. Roy +1 more
TL;DR: In this paper, the authors used optogenetic methods to increase dendritic spine density on DG memory engram cells in treatment methods for memory-impairment-associated diseases and conditions.
Journal Article
Biological Significance of the Proteasome Subunit LMP2/1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma
Takuma Hayashi,Akiko Horiuchi,Kenji Sano,Gal Gur,Hiroyuki Aburatani,Osamu Ishiko,Nobuo Yaegashi,Tanri Shiozawa,Yae Kanai,Dorit Zharhary,Susumu Tonegawa,Ikuo Konishi +11 more
TL;DR: Analysis of a human Ut-LMS cell line clarified the biological significance of LMP2/b1i in malignant myometrium transformation and the cell cycle, thus implicating LMP 2/ b1i as an anti-tumorigenic candidate.
Journal ArticleDOI
The Identification of Somatic Mutations in Interferon-g Signal Molecules in Human Uterine Leiomyosarcoma
Takuma Hayashi,Tomoyuki Ichimura,Hirofumi Ando,Koichi Ida,Miki Kawano,Tanri Shiozawa,Susumu Tonegawa,Yae Kanai,Hiroyuki Aburatani,Nobuo Yaegashi,Ikuo Konishi +10 more
TL;DR: The use of research findings of the experiment with mouse model has been successful in increasing the knowledge and understanding of how alterations, in relevant oncogenic, tumour suppressive, and signaling pathways directly impact sarcomagenesis, and may lead to identification of new diagnostic candidates or therapeutic targets in human uterine LMS.
Journal ArticleDOI
Identification of Novel Biomarker For Human Uterine Leiomyosarcoma
Takuma Hayashi,Akiko Horiuchi,Hiroyuki Aburatani,Osamu Ishiko,Nobuo Yaegashi,Yae Kanai,Dorit Zharhary,Susumu Tonegawa,Ikuo Konishi +8 more
TL;DR: It has been shown that LMP2/b1i expression was absent in human Ut-LMS, but present in other human uterine mesenchymal tumors including uterine LMA, and defective-LMP 2/b 1i expression may be one of the risk factors for human ULTIMATE leiomyosarcoma.