S
Susumu Tonegawa
Researcher at Massachusetts Institute of Technology
Publications - 419
Citations - 85400
Susumu Tonegawa is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & T-cell receptor. The author has an hindex of 150, co-authored 416 publications receiving 79814 citations. Previous affiliations of Susumu Tonegawa include University of Zurich & RIKEN Brain Science Institute.
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Journal ArticleDOI
Distinct preplay of multiple novel spatial experiences in the rat
George Dragoi,Susumu Tonegawa +1 more
TL;DR: These findings suggest that the place cell sequence of a novel spatial experience is determined, in part, by an online selection of a subset of cellular firing sequences from a larger repertoire of preexisting temporal firing sequences in the hippocampal cellular assembly network that become rapidly bound to the novel experience.
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Unusual organization and diversity of T-cell receptor a-chain genes
Adrian Hayday,Adrian Hayday,Don J. Diamond,Gary Tanigawa,Joseph S. Heilig,Virginia Folsom,Haruo Saito,Susumu Tonegawa +7 more
TL;DR: An initial characterization of the murine T-cell receptor α-chain gene family is presented, and it is concluded that although it is clearly related to the gene families encoding immunoglobulins18, T- Cell receptor β-chains10–16 and also T- cell γ-chains17, it shows unique characteristics.
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Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes.
TL;DR: By demonstrating that a variety of different cell types can be thus converted into target cells for CTL, the approach described in this study may provide opportunities to analyze further the mechanisms by which CTL destroy target cells.
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NMDA receptor-dependent refinement of somatotopic maps.
Takuji Iwasato,Reha S. Erzurumlu,Patricio T. Huerta,Dong Feng Chen,Toshikuni Sasaoka,Emel Ulupinar,Susumu Tonegawa +6 more
TL;DR: It is demonstrated that ectopic expression of a transgene of an NMDAR1 splice variant rescues neonatally fatal N MDAR1 knockout (KO) mice, although the average life span varies depending on the level of the transGene expression.
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Immunobiology of Murine T Cruzi Infection: The Predominance of Parasite-nonspecific Responses and the Activation of TCRIT Cells
TL;DR: Presentation des connaissances actuelles concernant l'immunobiologie de la relation hote-parasite chez l'infection de la souris par Trypanosoma cruzi.