S
Susumu Tonegawa
Researcher at Massachusetts Institute of Technology
Publications - 419
Citations - 85400
Susumu Tonegawa is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & T-cell receptor. The author has an hindex of 150, co-authored 416 publications receiving 79814 citations. Previous affiliations of Susumu Tonegawa include University of Zurich & RIKEN Brain Science Institute.
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Journal ArticleDOI
A Role for Calcium-Permeable AMPA Receptors in Synaptic Plasticity and Learning
Brian J. Wiltgen,Brian J. Wiltgen,Gordon Royle,Erin E. Gray,Andrea Abdipranoto,Nopporn Thangthaeng,Nathan S. Jacobs,Faysal Saab,Susumu Tonegawa,Stephen F. Heinemann,Thomas J. O'Dell,Michael S. Fanselow,Bryce Vissel +12 more
TL;DR: Results suggest that GluR2-lacking AMPARs play a functional and previously unidentified role in learning; they appear to mediate changes in synaptic strength that occur after plasticity has been established by NMDARs.
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Direct excitation of parvalbumin‐positive interneurons by M1 muscarinic acetylcholine receptors: roles in cellular excitability, inhibitory transmission and cognition
Feng Yi,Jackson Ball,Kurt Stoll,Vaishali C. Satpute,Samantha M. Mitchell,Jordan L. Pauli,Benjamin B. Holloway,April Johnston,Neil M. Nathanson,Karl Deisseroth,David Gerber,Susumu Tonegawa,J. Josh Lawrence +12 more
TL;DR: In this article, the authors examined PV interneurons in hippocampus (HC) and prefrontal cortex (PFC) and their modulation by muscarinic acetylcholine receptors (mAChRs).
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Presentation of endogenous viral proteins in association with major histocompatibility complex class II: On the role of intracellular compartmentalization, invariant chain and the TAP transporter system
Annette Oxenius,Martin F. Bachmann,Philip G. Ashton-Rickardt,Susumu Tonegawa,Rolf M. Zinkernagel,Hans Hengartner +5 more
TL;DR: The MHC class II‐associated presentation of endogenously synthesized membrane associated glycoprotein and the cytosolic nucleoprotein of lymphocytic choriomeningitis virus in professional antigen presenting cells (APC) of mice was efficient and could not be inhibited by chloroquine or leupeptin.
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Tap1-independent loading of class i molecules by exogenous viral proteins
Martin F. Bachmann,Annette Oxenius,Hanspeter Pircher,Hans Hengartner,Philip A. Ashton-Richardt,Susumu Tonegawa,Rolf M. Zinkernagel +6 more
TL;DR: It is found that recombinant glycoand nucleop protein from lymphocytic choriomeningitis virus and nucleoprotein of vesicular stomatitis virus were presented as efficiently by TAP1 −/− cells as by control cells, suggesting this new, TAP‐independent pathway of class I‐associated antigen presentation may be applicable for vaccine strategies.
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Somatic mutation creates diversity in the major group of mouse immunoglobulin kappa light chains.
TL;DR: It is concluded that, as in the lambda 1 light chains, the variant V regions are encoded by gene segments derived by a few somatic mutations from the corresponding germ line DNA.