S
Susumu Tonegawa
Researcher at Massachusetts Institute of Technology
Publications - 419
Citations - 85400
Susumu Tonegawa is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & T-cell receptor. The author has an hindex of 150, co-authored 416 publications receiving 79814 citations. Previous affiliations of Susumu Tonegawa include University of Zurich & RIKEN Brain Science Institute.
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Journal ArticleDOI
Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice.
Atsu Aiba,Masanobu Kano,Chong Chen,Chong Chen,Mark E. Stanton,Gregory D. Fox,Karl Herrup,Theresa A. Zwingman,Susumu Tonegawa,Susumu Tonegawa +9 more
TL;DR: It is concluded that mGLUR1 is required for the induction of LTD and that the ataxic behavior and impaired eyeblink conditioning of the mGluR1 mutant mice are primarily due to deficient LTD.
Journal ArticleDOI
Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network
Thomas J. McHugh,Matt Jones,Matt Jones,Jennifer J. Quinn,Jennifer J. Quinn,Nina Balthasar,Nina Balthasar,Roberto Coppari,Roberto Coppari,Joel K. Elmquist,Bradford B. Lowell,Michael S. Fanselow,Matthew A. Wilson,Susumu Tonegawa +13 more
TL;DR: Evidence is provided that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation, by generating and analyzing a mouse strain that lacks the gene encoding the essential subunit of the N-methyl-d-aspartate (NMDA) receptor NR1 in dentates gyrus granule Cells.
Journal ArticleDOI
Translational control by MAPK signaling in long-term synaptic plasticity and memory.
Raymond J. Kelleher,Raymond J. Kelleher,Arvind Govindarajan,Hae-Yoon Jung,Hyejin Kang,Susumu Tonegawa +5 more
TL;DR: A crucial role is suggested for translational control by MAPK signaling in long-lasting forms of synaptic plasticity and memory in hippocampal neurons.
Journal ArticleDOI
Gamma/delta cells
TL;DR: Preliminary results of experiments with gene knock out mice suggest that gamma delta T cells do not function as helper cells in humoral immune responses but may complement alpha beta T cells in the defense against various microorganisms.
Journal ArticleDOI
Creating a False Memory in the Hippocampus
Steve Ramirez,Xu Liu,Xu Liu,Pei-Ann Lin,Junghyup Suh,Michele Pignatelli,Roger L. Redondo,Roger L. Redondo,Tomás J. Ryan,Tomás J. Ryan,Susumu Tonegawa,Susumu Tonegawa +11 more
TL;DR: The data demonstrate that it is possible to generate an internally represented and behaviorally expressed fear memory via artificial means through reactivation of memory engram–bearing cells in the hippocampus.