D
Dwaipayan Bharadwaj
Researcher at Institute of Genomics and Integrative Biology
Publications - 81
Citations - 4817
Dwaipayan Bharadwaj is an academic researcher from Institute of Genomics and Integrative Biology. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 27, co-authored 75 publications receiving 4202 citations. Previous affiliations of Dwaipayan Bharadwaj include Council of Scientific and Industrial Research & Academy of Scientific and Innovative Research.
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Journal ArticleDOI
The genetic architecture of type 2 diabetes
Christian Fuchsberger,Christian Fuchsberger,Jason Flannick,Jason Flannick,Tanya M. Teslovich,Anubha Mahajan,Vineeta Agarwala,Vineeta Agarwala,Kyle J. Gaulton,Clement Ma,Pierre Fontanillas,Loukas Moutsianas,Davis J. McCarthy,Manuel A. Rivas,John R. B. Perry,Xueling Sim,Thomas W. Blackwell,Neil Robertson,N. William Rayner,N. William Rayner,Pablo Cingolani,Adam E. Locke,Juan Fernandez Tajes,Heather M. Highland,Josée Dupuis,Josée Dupuis,Peter S. Chines,Cecilia M. Lindgren,Cecilia M. Lindgren,Christopher Hartl,Anne U. Jackson,Han Chen,Han Chen,Jeroen R. Huyghe,Martijn van de Bunt,Richard D. Pearson,Ashok Kumar,Ashok Kumar,Martina Müller-Nurasyid,Niels Grarup,Heather M. Stringham,Eric R. Gamazon,Jae-Hoon Lee,Yi Chen,Robert A. Scott,Jennifer E. Below,Peng Chen,Jinyan Huang,Min Jin Go,Michael L. Stitzel,Dorota Pasko,Stephen C. J. Parker,Tibor V. Varga,Todd Green,Nicola L. Beer,Aaron G. Day-Williams,Teresa Ferreira,Tasha E. Fingerlin,Momoko Horikoshi,Cheng Hu,Iksoo Huh,Mohammad Kamran Ikram,Mohammad Kamran Ikram,Bong-Jo Kim,Yongkang Kim,Young-Jin Kim,Min-Seok Kwon,Juyoung Lee,Selyeong Lee,Keng-Han Lin,Taylor J. Maxwell,Yoshihiko Nagai,Xu Wang,Ryan P. Welch,Joon Yoon,Weihua Zhang,Weihua Zhang,Nir Barzilai,Benjamin F. Voight,Bok-Ghee Han,Christopher P. Jenkinson,Christopher P. Jenkinson,Teemu Kuulasmaa,Johanna Kuusisto,Alisa K. Manning,Maggie C.Y. Ng,Nicholette D. Palmer,Beverley Balkau,Alena Stančáková,Hanna E. Abboud,Heiner Boeing,Vilmantas Giedraitis,Dorairaj Prabhakaran,Omri Gottesman,James Scott,Jason Carey,Phoenix Kwan,George B. Grant,Joshua D. Smith,Benjamin M. Neale,Benjamin M. Neale,Shaun Purcell,Shaun Purcell,Shaun Purcell,Adam S. Butterworth,Joanna M. M. Howson,Heung Man Lee,Yingchang Lu,Soo Heon Kwak,Wei Zhao,John Danesh,John Danesh,Vincent K. L. Lam,Kyong Soo Park,Danish Saleheen,Wing-Yee So,Claudia H. T. Tam,Uzma Afzal,David Aguilar,Rector Arya,Tin Aung,Tin Aung,Edmund Chan,Carmen Navarro,Ching-Yu Cheng,Ching-Yu Cheng,Domenico Palli,Adolfo Correa,Joanne E. Curran,Denis Rybin,Vidya S. Farook,Sharon P. Fowler,Barry I. Freedman,Michael Griswold,Daniel E. Hale,Pamela J. Hicks,Chiea Chuen Khor,Satish Kumar,Benjamin Lehne,Dorothée Thuillier,Wei-Yen Lim,Jianjun Liu,Jianjun Liu,Yvonne T. van der Schouw,Marie Loh,Marie Loh,Marie Loh,Solomon K. Musani,Sobha Puppala,William R. Scott,Loic Yengo,Sian-Tsung Tan,Sian-Tsung Tan,Herman A. Taylor,Farook Thameem,Gregory P. Wilson,Tien Yin Wong,Tien Yin Wong,Pål R. Njølstad,Jonathan C. Levy,Massimo Mangino,Lori L. Bonnycastle,Thomas Schwarzmayr,João Fadista,Gabriela L. Surdulescu,Christian Herder,Christopher J. Groves,Thomas Wieland,Jette Bork-Jensen,Ivan Brandslund,Cramer Christensen,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Alex S. F. Doney,Leena Kinnunen,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andrew Farmer,Liisa Hakaste,Dylan Hodgkiss,Jasmina Kravic,Valeriya Lyssenko,Mette Hollensted,Marit E. Jørgensen,Torben Jørgensen,Torben Jørgensen,Claes Ladenvall,Johanne Marie Justesen,Annemari Käräjämäki,Jennifer Kriebel,Wolfgang Rathmann,Lars Lannfelt,Torsten Lauritzen,Narisu Narisu,Allan Linneberg,Olle Melander,Lili Milani,Matt Neville,Marju Orho-Melander,Lu Qi,Qibin Qi,Qibin Qi,Michael Roden,Olov Rolandsson,Amy J. Swift,Anders Rosengren,Kathleen Stirrups,Andrew R. Wood,Evelin Mihailov,Christine Blancher,Mauricio O. Carneiro,Jared Maguire,Ryan Poplin,Khalid Shakir,Timothy Fennell,Mark A. DePristo,Martin Hrabé de Angelis,Panos Deloukas,Panos Deloukas,Anette P. Gjesing,Goo Jun,Goo Jun,Peter M. Nilsson,Jacquelyn Murphy,Robert C. Onofrio,Barbara Thorand,Torben Hansen,Torben Hansen,Christa Meisinger,Frank B. Hu,Bo Isomaa,Fredrik Karpe,Liming Liang,Annette Peters,Cornelia Huth,Stephen O'Rahilly,Colin N. A. Palmer,Oluf Pedersen,Rainer Rauramaa,Jaakko Tuomilehto,Veikko Salomaa,Richard M. Watanabe,Ann-Christine Syvänen,Richard N. Bergman,Dwaipayan Bharadwaj,Erwin P. Bottinger,Yoon Shin Cho,Giriraj R. Chandak,Juliana C.N. Chan,Kee Seng Chia,Mark J. Daly,Shah Ebrahim,Claudia Langenberg,Paul Elliott,Kathleen A. Jablonski,Donna M. Lehman,Weiping Jia,Ronald C.W. Ma,Toni I. Pollin,Manjinder S. Sandhu,Manjinder S. Sandhu,Nikhil Tandon,Philippe Froguel,Philippe Froguel,Inês Barroso,Inês Barroso,Yik Ying Teo,Eleftheria Zeggini,Ruth J. F. Loos,Kerrin S. Small,Janina S. Ried,Ralph A. DeFronzo,Harald Grallert,Benjamin Glaser,Andres Metspalu,Nicholas J. Wareham,Mark Walker,Eric Banks,Christian Gieger,Erik Ingelsson,Erik Ingelsson,Hae Kyung Im,Thomas Illig,Paul W. Franks,Paul W. Franks,Paul W. Franks,Gemma Buck,Joseph Trakalo,David Buck,Inga Prokopenko,Inga Prokopenko,Reedik Mägi,Lars Lind,Yossi Farjoun,Katharine R. Owen,Anna L. Gloyn,Konstantin Strauch,Tiinamaija Tuomi,Jaspal S. Kooner,Jaspal S. Kooner,Jong-Young Lee,Taesung Park,Peter Donnelly,Andrew D. Morris,Andrew D. Morris,Andrew T. Hattersley,Donald W. Bowden,Francis S. Collins,Gil Atzmon,Gil Atzmon,John C. Chambers,John C. Chambers,Tim D. Spector,Markku Laakso,Tim M. Strom,Graeme I. Bell,John Blangero,Ravindranath Duggirala,E. Shyong Tai,Gilean McVean,Craig L. Hanis,James G. Wilson,Mark Seielstad,Mark Seielstad,Timothy M. Frayling,James B. Meigs,Nancy J. Cox,Robert Sladek,Eric S. Lander,Stacey Gabriel,Noël P. Burtt,Karen L. Mohlke,Thomas Meitinger,Leif Groop,Leif Groop,Gonçalo R. Abecasis,Jose C. Florez,Jose C. Florez,Laura J. Scott,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Hyun Min Kang,Michael Boehnke,David Altshuler,David Altshuler,David Altshuler,Mark I. McCarthy +349 more
TL;DR: In this paper, the authors performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing for 12,940 individuals from five ancestry groups.
The genetic architecture of type 2 diabetes
Christian Fuchsberger,Jason Flannick,Tanya M. Teslovich,Anubha Mahajan,Vineeta Agarwala,Kyle J. Gaulton,Clement Ma,Pierre Fontanillas,Loukas Moutsianas,Davis J. McCarthy,Manuel A. Rivas,John R. B. Perry,Xueling Sim,Thomas W. Blackwell,Neil Robertson,N. William Rayner,Pablo Cingolani,Adam E. Locke,Juan Fernandez Tajes,Heather M. Highland,Josée Dupuis,Peter S. Chines,Cecilia M. Lindgren,Christopher Hartl,Anne U. Jackson,Han Chen,Jeroen R. Huyghe,Martijn van de Bunt,Richard D. Pearson,Ashok Kumar,Martina Mueller-Nurasyid,Niels Grarup,Heather M. Stringham,Eric R. Gamazon,Jae-Hoon Lee,Yi Chen,Robert A. Scott,Jennifer E. Below,Peng Chen,Jinyan Huang,Min Jin Go,Michael L. Stitzel,Dorota Pasko,Stephen C. J. Parker,Tibor V. Varga,Todd Green,Nicola L. Beer,Aaron G. Day-Williams,Teresa Ferreira,Tasha E. Fingerlin,Momoko Horikoshi,Cheng Hu,Iksoo Huh,Mohammad Kamran Ikram,Bong-Jo Kim,Yongkang Kim,Young-Jin Kim,Min-Seok Kwon,Juyoung Lee,Selyeong Lee,Keng-Han Lin,Taylor J. Maxwell,Yoshihiko Nagai,Xu Wang,Ryan P. Welch,Joon Yoon,Weihua Zhang,Nir Barzilai,Benjamin F. Voight,Bok-Ghee Han,Christopher P. Jenkinson,Teemu Kuulasmaa,Johanna Kuusisto,Alisa K. Manning,Maggie C.Y. Ng,Nicholette D. Palmer,Beverley Balkau,Alena Stančáková,Hanna E. Abboud,Heiner Boeing,Vilmantas Giedraitis,Dorairaj Prabhakaran,Omri Gottesman,James Scott,Jason Carey,Phoenix Kwan,George B. Grant,Joshua D. Smith,Benjamin M. Neale,Shaun Purcell,Adam S. Butterworth,Joanna M. M. Howson,Heung Man Lee,Yingchang Lu,Soo Heon Kwak,Wei Zhao,John Danesh,Vincent K. L. Lam,Kyong Soo Park,Danish Saleheen,Wing-Yee So,Claudia H. T. Tam,Uzma Afzal,David Aguilar,Rector Arya,Tin Aung,Edmund Chan,Carmen Navarro,Ching-Yu Cheng,Domenico Palli,Adolfo Correa,Joanne E. Curran,Denis Rybin,Vidya S. Farook,Sharon P. Fowler,Barry I. Freedman,Michael Griswold,Daniel E. Hale,Pamela J. Hicks,Chiea Chuen Khor,Satish Kumar,Benjamin Lehne,Dorothée Thuillier,Wei-Yen Lim,Jianjun Liu,Yvonne T. van der Schouw,Marie Loh,Solomon K. Musani,Sobha Puppala,William R. Scott,Loic Yengo,Sian-Tsung Tan,Herman A. Taylor,Farook Thameem,Gregory P. Wilson,Tien Yin Wong,Pål R. Njølstad,Jonathan C. Levy,Massimo Mangino,Lori L. Bonnycastle,Thomas Schwarzmayr,João Fadista,Gabriela L. Surdulescu,Christian Herder,Christopher J. Groves,Thomas Wieland,Jette Bork-Jensen,Ivan Brandslund,Cramer Christensen,Heikki A. Koistinen,Alex S. F. Doney,Leena Kinnunen,Tõnu Esko,Andrew Farmer,Liisa Hakaste,Dylan Hodgkiss,Jasmina Kravic,Valeriya Lyssenko,Mette Hollensted,Marit E. Jørgensen,Torben Jørgensen,Claes Ladenvall,Johanne Marie Justesen,Annemari Käräjämäki,Jennifer Kriebel,Wolfgang Rathmann,Lars Lannfelt,Torsten Lauritzen,Narisu Narisu,Allan Linneberg,Olle Melander,Lili Milani,Matt Neville,Marju Orho-Melander,Lu Qi,Qibin Qi,Michael Roden,Olov Rolandsson,Amy J. Swift,Anders Rosengren,Kathleen Stirrups,Andrew R. Wood,Evelin Mihailov,Christine Blancher,Mauricio O. Carneiro,Jared Maguire,Ryan Poplin,Khalid Shakir,Timothy R. Fennell,Mark A. DePristo,Martin Hrabé de Angelis,Panos Deloukas,Anette P. Gjesing,Goo Jun,Peter M. Nilsson,Jacquelyn Murphy,Robert C. Onofrio,Barbara Thorand,Torben Hansen,Christa Meisinger,Frank B. Hu,Bo Isomaa,Fredrik Karpe,Liming Liang,Annette Peters,Cornelia Huth,Stephen O'Rahilly,Colin N. A. Palmer,Oluf Pedersen,Rainer Rauramaa,Jaakko Tuomilehto,Veikko Salomaa,Richard M. Watanabe,Ann-Christine Syvänen,Richard N. Bergman,Dwaipayan Bharadwaj,Erwin P. Bottinger,Yoon Shin Cho,Giriraj R. Chandak,Juliana C.N. Chan,Kee Seng Chia,Mark J. Daly,Shah Ebrahim,Claudia Langenberg,Paul Elliott,Kathleen A. Jablonski,Donna M. Lehman,Weiping Jia,Ronald C.W. Ma,Toni I. Pollin,Manjinder S. Sandhu,Nikhil Tandon,Philippe Froguel,Inês Barroso,Yik Ying Teo,Eleftheria Zeggini,Ruth J. F. Loos,Kerrin S. Small,Janina S. Ried,Ralph A. DeFronzo,Harald Grallert,Benjamin Glaser,Andres Metspalu,Nicholas J. Wareham,Mark Walker,Eric Banks,Christian Gieger,Erik Ingelsson,Hae Kyung Im,Thomas Illig,Paul W. Franks,Gemma Buck,Joseph Trakalo,David Buck,Inga Prokopenko,Reedik Mägi,Lars Lind,Yossi Farjoun,Katharine R. Owen,Anna L. Gloyn,Konstantin Strauch,Tiinamaija Tuomi,Jaspal S. Kooner,Jong-Young Lee,Taesung Park,Peter Donnelly,Andrew D. Morris,Andrew T. Hattersley,Donald W. Bowden,Francis S. Collins,Gil Atzmon,John C. Chambers,Tim D. Spector,Markku Laakso,Tim M. Strom,Graeme I. Bell,John Blangero,Ravindranath Duggirala,E. Shyong Tai,Gilean McVean,Craig L. Hanis,James G. Wilson,Mark Seielstad,Timothy M. Frayling,James B. Meigs,Nancy J. Cox,Robert Sladek,Eric S. Lander,Stacey Gabriel,Noël P. Burtt,Karen L. Mohlke,Thomas Meitinger,Leif Groop,Gonçalo R. Abecasis,Jose C. Florez,Laura J. Scott,Andrew P. Morris,Hyun Min Kang,Michael Boehnke,David Altshuler,Mark I. McCarthy +300 more
TL;DR: Large-scale sequencing does not support the idea that lower-frequency variants have a major role in predisposition to type 2 diabetes, but most fell within regions previously identified by genome-wide association studies.
Journal ArticleDOI
The major receptor for C-reactive protein on leukocytes is fcgamma receptor II.
Dwaipayan Bharadwaj,Mary-Pat Stein,Michael Volzer,Carolyn Mold,Terry W. Du Clos,Terry W. Du Clos +5 more
TL;DR: It is determined that CRP also interacts with FcγRIIa (CD32), the low affinity receptor for IgG on monocytes and neutrophils, and this interaction could not account for the majority of binding of CRP to neutrophil or monocytic cells.
Journal ArticleDOI
Genetic landscape of the people of India: A canvas for disease gene exploration
Samir K. Brahmachari,Partha P. Majumder,Mitali Mukerji,Saman Habib,Debasis Dash,Kunal Ray,Samira Bahl,Lalji Singh,Abhay Sharma,Susanta Roychoudhury,Giriraj R. Chandak,Kumarasamy Thangaraj,Devendra Parmar,Shantanu Sengupta,Dwaipayan Bharadwaj,Srikanta Kumar Rath,Jagmohan Singh,Ganga Nath Jha,Komal Virdi,V. R. Rao,Swapnil Sinha,Ashok K. Singh,Amit Kumar Mitra,Shrawan K. Mishra,Qadar Pasha,Sridhar Sivasubbu,Rajesh Pandey,Aradhita Baral,Prashant Singh,Amitabh Sharma,Jitender Kumar,Tsering Stobdan,Yasha Bhasin,Chitra Chauhan,Ashiq Hussain,Elyanambi Sundaramoorthy,Suchita Singh,Arun Bandyopadhyay,Krishanu Dasgupta,A. K. Reddy,Charles J. Spurgeon,M. Mohd Idris,Vinay K. Khanna,Alok Dhawan,Mohini Anand,Ravi Shankar,R. S. Bharti,Madhu Singh,Arvind P. Singh,Anwar J. Khan,Parag P. Shah,A. B. Pant,Rupinder Kaur,Kamlesh Bisht,Ashok Kumar,Victor Rajamanickam,Eugene Wilson,Antony Thangadurai,Pankaj Jha,Mahua Maulik,Neelam Makhija,Abdur Rahim,Sangeeta Sharma,Rupali Chopra,Pooja Rana,Manickam Chidambaram,Arindam Maitra,Ruchi Chawla,Suruchika Soni,Preeti Khurana,Mohamed Nadeem Khan,Sushanta Das Sutar,Amit Tuteja,K. Narayansamy,Rachna Shukla,S. Prakash,Swapna Mahurkar,K. Radha Mani,J. Hemavathi,Seema Bhaskar,Pankaj Khanna,G. S. Ramalakshmi,Shalini Mani Tripathi,Nikita Thakur,Balaram Ghosh,Ritushree Kukreti,Taruna Madan,Ranjana Verma,G. Sudheer,Anubha Mahajan,Sreenivas Chavali,Rubina Tabassum,Sandeep Grover,Meenal Gupta,Jyotsna Batra,Amrendra Kumar,Abdoulazim Nejatizadeh,Mudit Vaid,Swapan K Das,Shilpy Sharma,Mamta Sharma,Rajshekhar Chatterjee,Jinny A. Paul,Pragya Srivastava,Charu Rajput,Uma Mittal,Mridula Singh,Manoj Hariharan,S.K. Das,Keya Chaudhuri,Mainak Sengupta,Moulinath Acharya,Ashima Bhattacharyya,A Saha,Arindam Biswas,Moumita Chaki,Arnab Gupta,Saibal Mukherjee,Suddhasil Mookherjee,Ishita Chattopadhyay,Taraswi Banerjee,Meenakshi Chakravorty,Chaitali Misra,Gourish Monadal,Shiladitya Sengupta,Dipanjana Dutta De,Swati Bajaj,Ishani Deb,Arunava Banerjee,Rajdeep Chowdhury,Debalina Banerjee,Deepak Kumar,Sumit Ranjan Das,Shrish Tiwari,Anshu Bharadwaj,Ikhlak Ahmed,Sumera Parveen,Nivedita Singh,Dipayan Dasgupta,Siddharth Singh Bisht,Sangeeta Khanna,Rashmi Rajput,Biswaroop Ghosh,Naveen Kumar,Amit Kumar Chaurasia,James Kappukalayil Abraham,Amit Sinha,Vinod Scaria,Tavpritesh Sethi,A. Mandal,Arijit Mukhopadhyay +150 more
TL;DR: High levels of genetic divergence are observed between groups of populations that cluster largely on the basis of ethnicity and language in diverse populations of India.
Journal ArticleDOI
C-reactive protein binding to FcγRIIa on human monocytes and neutrophils is allele-specific
Mary-Pat Stein,Jeffrey C. Edberg,Robert P. Kimberly,Erin K. Mangan,Dwaipayan Bharadwaj,Carolyn Mold,Terry W. Du Clos +6 more
TL;DR: Direct genetic evidence is provided for FcgammaRIIa as the functional, high-affinity CRP receptor on leukocytes while emphasizing the reciprocal relationship between IgG and CRP binding avidities.