S
Swee Lay Thein
Researcher at National Institutes of Health
Publications - 335
Citations - 21617
Swee Lay Thein is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Fetal hemoglobin & Population. The author has an hindex of 62, co-authored 316 publications receiving 19670 citations. Previous affiliations of Swee Lay Thein include King's College & University of Oxford.
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Journal ArticleDOI
Hypervariable 'minisatellite' regions in human DNA.
TL;DR: A probe based on a tandem-repeat of the core sequence can detect many highly variable loci simultaneously and can provide an individual-specific DNA ‘fingerprint’ of general use in human genetic analysis.
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Individual-specific 'fingerprints' of human DNA.
TL;DR: It is shown that other variant (core)n probes can detect additional sets of hypervariable minisatellites to produce somatically stable DNA ‘fingerprints’ which are completely specific to an individual (or to his or her identical twin) and can be applied directly to problems of human identification, including parenthood testing.
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Selection of housekeeping genes for gene expression studies in human reticulocytes using real-time PCR
TL;DR: GAPDH was found to be the most suitable housekeeping gene for expression studies in reticulocytes while the commonly used B2M should be avoided.
Journal ArticleDOI
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
Nicole Soranzo,Nicole Soranzo,Tim D. Spector,Massimo Mangino,Brigitte Kühnel,Augusto Rendon,Alexander Teumer,Christina Willenborg,Benjamin J. Wright,Li Chen,Mingyao Li,Perttu Salo,Perttu Salo,Benjamin F. Voight,Benjamin F. Voight,Philippa Burns,Roman A. Laskowski,Yali Xue,Stephan Menzel,David Altshuler,John Bradley,Suzannah Bumpstead,Mary-Susan Burnett,Joseph M. Devaney,Angela Döring,Roberto Elosua,Stephen E. Epstein,Wendy N. Erber,Mario Falchi,Mario Falchi,Stephen F. Garner,Mohammed J. R. Ghori,Alison H. Goodall,Rhian Gwilliam,Hakon Hakonarson,Alistair S. Hall,Naomi Hammond,Christian Hengstenberg,Thomas Illig,Inke R. König,Christopher W. Knouff,Ruth McPherson,Olle Melander,Vincent Mooser,Matthias Nauck,Markku S. Nieminen,Christopher J. O'Donnell,Leena Peltonen,Leena Peltonen,Simon C. Potter,Holger Prokisch,Daniel J. Rader,Catherine M. Rice,Robert Roberts,Veikko Salomaa,Veikko Salomaa,Jennifer G. Sambrook,Stefan Schreiber,Heribert Schunkert,Stephen M. Schwartz,Jovana Serbanovic-Canic,Juha Sinisalo,David S. Siscovick,Klaus Stark,Ida Surakka,Jonathan Stephens,John R. Thompson,Uwe Völker,Henry Völzke,Nicholas A. Watkins,George A. Wells,H-Erich Wichmann,David A. van Heel,Chris Tyler-Smith,Swee Lay Thein,Sekar Kathiresan,Markus Perola,Markus Perola,Muredach P. Reilly,Alexandre F.R. Stewart,Jeanette Erdmann,Nilesh J. Samani,Christa Meisinger,Andreas Greinacher,Panos Deloukas,Willem H. Ouwehand,Willem H. Ouwehand,Christian Gieger +87 more
TL;DR: A long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction is identified and it is shown that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.
Journal ArticleDOI
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.
Stephan Menzel,Chad Garner,Ivo Gut,Fumihiko Matsuda,Masao Yamaguchi,Simon Heath,Mario Foglio,Diana Zelenika,Anne Boland,Helen Rooks,Steve Best,Tim D. Spector,Martin Farrall,G. Mark Lathrop,Swee Lay Thein,Swee Lay Thein +15 more
TL;DR: A genome-wide association mapping strategy is applied to individuals with contrasting extreme trait values and a new F cell quantitative trait locus is mapped to BCL11A, which encodes a zinc-finger protein, on chromosome 2p15.