T
Tamas L. Horvath
Researcher at Yale University
Publications - 513
Citations - 48274
Tamas L. Horvath is an academic researcher from Yale University. The author has contributed to research in topics: Hypothalamus & Energy homeostasis. The author has an hindex of 107, co-authored 483 publications receiving 42023 citations. Previous affiliations of Tamas L. Horvath include Humboldt State University & University of West Hungary.
Papers
More filters
Journal ArticleDOI
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Michael A. Cowley,James L. Smart,Marcelo Rubinstein,Marcelo G. Cerdán,Sabrina Diano,Tamas L. Horvath,Roger D. Cone,Malcolm J. Low +7 more
TL;DR: An integrated model of leptin action and neuronal architecture in the arcuate nucleus of the hypothalamus is proposed and it is shown that melanocortin peptides have an autoinhibitory effect on this circuit.
Journal ArticleDOI
The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis
Michael A. Cowley,Roy G. Smith,Sabrina Diano,Matthias H. Tschöp,Nina Pronchuk,Kevin L. Grove,Christian J. Strasburger,Martin Bidlingmaier,Michael Esterman,Mark L. Heiman,Luis M. Garcia-Segura,Eduardo A. Nillni,Pablo Mendez,Malcolm J. Low,Péter Sótonyi,Jeffrey M. Friedman,Hongyan Liu,Shirly Pinto,William F. Colmers,Roger D. Cone,Tamas L. Horvath +20 more
TL;DR: Using electrophysiological recordings, ghrelin stimulated the activity of arcuate NPY neurons and mimicked the effect of NPY in the paraventricular nucleus of the hypothalamus (PVH), thus representing a novel regulatory circuit controlling energy homeostasis.
Journal ArticleDOI
Interacting appetite-regulating pathways in the hypothalamic regulation of body weight.
TL;DR: Multiple orexigenic and anorexigenic pathways in the hypothalamic ARN appear to represent redundancy, a characteristic of regulated biological systems to provide a "fail-safe" neural mechanism to meet an organism's constant energy needs for growth and maintenance.
Journal ArticleDOI
Obesity is associated with hypothalamic injury in rodents and humans
Joshua P. Thaler,Chun-Xia Yi,Ellen A. Schur,Stephan J. Guyenet,Bang H. Hwang,Marcelo O. Dietrich,Xiaolin Zhao,David A. Sarruf,Vitaly Izgur,Kenneth R. Maravilla,Hong T. Nguyen,Jonathan D. Fischer,Miles E. Matsen,Brent E. Wisse,Gregory J. Morton,Tamas L. Horvath,Denis G. Baskin,Matthias H. Tschöp,Michael W. Schwartz +18 more
TL;DR: Obesity is associated with neuronal injury in a brain area crucial for body weight control in both humans and rodent models, and evidence of increased gliosis in the mediobasal hypothalamus of obese humans is found.
Journal ArticleDOI
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
Yun-Hee Youm,Kim Y. Nguyen,Ryan W. Grant,Emily L. Goldberg,Monica Bodogai,Dongin Kim,Dominic P. D’Agostino,Noah J. Planavsky,Christopher R. Lupfer,Thirumala D. Kanneganti,Seokwon Kang,Tamas L. Horvath,Tarek M. Fahmy,Peter A. Crawford,Arya Biragyn,Emad S. Alnemri,Vishwa Deep Dixit +16 more
TL;DR: In vivo, BHB or a ketogenic diet attenuates caspase-1 activation and IL-1β secretion in mouse models of NLRP3-mediated diseases such as Muckle–Wells syndrome, familial cold autoinflammatory syndrome and urate crystal–induced peritonitis and the findings suggest that the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of theNLRP3 inflammasome.