T
Tao Chen
Researcher at Fourth Military Medical University
Publications - 128
Citations - 11519
Tao Chen is an academic researcher from Fourth Military Medical University. The author has contributed to research in topics: Long-term potentiation & Excitatory postsynaptic potential. The author has an hindex of 36, co-authored 111 publications receiving 8564 citations. Previous affiliations of Tao Chen include Xi'an Jiaotong University & UPRRP College of Natural Sciences.
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Journal ArticleDOI
Clinical and immunological features of severe and moderate coronavirus disease 2019.
Guang Chen,Di Wu,Wei Guo,Yong Cao,Da Huang,Hongwu Wang,Tao Wang,Xiaoyun Zhang,Huilong Chen,Haijing Yu,Xiaoping Zhang,Minxia Zhang,Shiji Wu,Jianxin Song,Tao Chen,Meifang Han,Shusheng Li,Xiaoping Luo,Jianping Zhao,Qin Ning +19 more
TL;DR: The SARS-CoV-2 infection may affect primarily T lymphocytes particularly CD4+T and CD8+ T cells, resulting in decrease in numbers as well as IFN-γ production, which may be of importance due to their correlation with disease severity in COVID-19.
Journal ArticleDOI
Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study.
Tao Chen,Di Wu,Huilong Chen,Weiming Yan,Danlei Yang,Guang Chen,Ke Ma,Dong Xu,Haijing Yu,Hongwu Wang,Tao Wang,Wei Guo,Jia Chen,Chen Ding,Xiaoping Zhang,Jiaquan Huang,Meifang Han,Shusheng Li,Xiaoping Luo,Jianping Zhao,Qin Ning +20 more
TL;DR: Severe acute respiratory syndrome coronavirus 2 infection can cause both pulmonary and systemic inflammation, leading to multi-organ dysfunction in patients at high risk, including patients with cardiovascular comorbidity.
Journal ArticleDOI
Sleep deprivation impairs cAMP signalling in the hippocampus
Christopher G. Vecsey,George S. Baillie,Devan Jaganath,Robbert Havekes,Andrew Daniels,Mathieu E. Wimmer,Ted Huang,Kim M. Brown,Xiang-Yao Li,Giannina Descalzi,Susan S. Kim,Tao Chen,Yuze Shang,Min Zhuo,Miles D. Houslay,Ted Abel +15 more
TL;DR: It is demonstrated that brief sleep deprivation disrupts hippocampal function by interfering with cAMP signalling through increased PDE4 activity, and drugs that enhance camp signalling may provide a new therapeutic approach to counteract the cognitive effects of sleep deprivation.
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Alleviating Neuropathic Pain Hypersensitivity by Inhibiting PKMζ in the Anterior Cingulate Cortex
Xiang-Yao Li,Xiang-Yao Li,Hyoung-Gon Ko,Tao Chen,Tao Chen,Giannina Descalzi,Kohei Koga,Hansen Wang,Susan S. Kim,Yuze Shang,Chuljung Kwak,Soowon Park,Jaehoon Shim,Jaehoon Shim,Kyungmin Lee,Kyungmin Lee,Graham L. Collingridge,Graham L. Collingridge,Bong-Kiun Kaang,Bong-Kiun Kaang,Min Zhuo,Min Zhuo +21 more
TL;DR: It is found that protein kinase M zeta (PKMζ) maintains pain-induced persistent changes in the mouse anterior cingulate cortex (ACC) and could be a new therapeutic target for treating chronic pain.
Journal ArticleDOI
Coexistence of Two Forms of LTP in ACC Provides a Synaptic Mechanism for the Interactions between Anxiety and Chronic Pain
Kohei Koga,Giannina Descalzi,Tao Chen,Tao Chen,Hyoung Gon Ko,Jinshan Lu,Shermaine Li,Junehee Son,Tae Hyun Kim,Chuljung Kwak,Richard L. Huganir,Ming Gao Zhao,Bong-Kiun Kaang,Graham L. Collingridge,Min Zhuo,Min Zhuo +15 more
TL;DR: This work characterized two forms of long-term potentiation in the anterior cingulate cortex (ACC) that require kainate receptors and a postsynaptic form (post-LTP) that requires N-methyl-D-aspartate receptors, providing a mechanism by which two form of LTP in the ACC may converge to mediate the interaction between anxiety and chronic pain.