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Theo M. Luider
Researcher at Erasmus University Rotterdam
Publications - 216
Citations - 8081
Theo M. Luider is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Mass spectrometry & Medicine. The author has an hindex of 46, co-authored 191 publications receiving 7253 citations. Previous affiliations of Theo M. Luider include Instituto Nacional de Saúde Dr. Ricardo Jorge & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4
Pierre-Olivier Mari,Bogdan I. Florea,Stephan P. Persengiev,Nicole S. Verkaik,Hennie T. Brüggenwirth,Mauro Modesti,Giuseppina Giglia-Mari,Karel Bezstarosti,Jeroen Demmers,Theo M. Luider,Adriaan B. Houtsmuller,Dik C. van Gent +11 more
TL;DR: Evidence is provided that a pulsed near IR laser can produce DSBs without any visible alterations in the nucleus, and it is shown that NHEJ proteins accumulate in the irradiated areas, and that XRCC4 may serve as a flexible tether between Ku70/80 and ligase IV.
Journal ArticleDOI
Proteomic Analysis of Exosomes Isolated from Human Malignant Pleural Effusions
Martin P. L. Bard,Joost P.J.J. Hegmans,Annabrita Hemmes,Theo M. Luider,Rob Willemsen,Lies-Anne A. Severijnen,Jan P. van Meerbeeck,Sjaak Burgers,Henk C. Hoogsteden,Bart N. Lambrecht +9 more
TL;DR: In conclusion, sucrose gradient ultracentrifugation allows isolation of exosomes from malignant pleural effusions, however, pleural fluid proteins and especially immunoglobulins are coisolated and may hamper the use ofExosomes isolated frommalignant effusion for immunotherapy programs.
Journal ArticleDOI
Proteomic Analysis of Exosomes Secreted by Human Mesothelioma Cells
Joost P.J.J. Hegmans,Martin P. L. Bard,Annabrita Hemmes,Theo M. Luider,Monique J. Kleijmeer,Jan-Bas Prins,Laurence Zitvogel,Sjaak Burgers,Henk C. Hoogsteden,Bart N. Lambrecht +9 more
TL;DR: Mesothelioma cells release exosomes that express a discrete set of proteins involved in antigen presentation, signal transduction, migration, and adhesion, which may play an important role in the interaction between tumor cells and their environment.
Journal ArticleDOI
Recommendations for Biomarker Identification and Qualification in Clinical Proteomics
Harald Mischak,Guenter Allmaier,Rolf Apweiler,Teresa K. Attwood,Marc Baumann,Ariela Benigni,Samuel E. Bennett,Rainer Bischoff,Erik Bongcam-Rudloff,Giovambattista Capasso,Joshua J. Coon,Patrick C. D'Haese,Anna F. Dominiczak,Mohammed Dakna,Hassan Dihazi,Jochen H. H. Ehrich,Patricia Fernández-Llama,Danilo Fliser,Jørgen Frøkiær,Jérôme Garin,Mark Girolami,William S. Hancock,Marion Haubitz,Denis F. Hochstrasser,Rury R. Holman,John P. A. Ioannidis,Joachim Jankowski,Bruce A. Julian,Jon B. Klein,Walter Kolch,Theo M. Luider,Ziad A. Massy,William B. Mattes,Franck Molina,Bernard Monsarrat,Jan Novak,Karlheinz Peter,Peter Rossing,Marta Sanchez-Carbayo,Joost P. Schanstra,O. John Semmes,Goce Spasovski,Dan Theodorescu,Visith Thongboonkerd,Raymond Vanholder,Timothy D. Veenstra,Eva M. Weissinger,Tadashi Yamamoto,Antonia Vlahou +48 more
TL;DR: It is asserted that successful studies generally use suitable statistical approaches for biomarker definition and confirm results in independent test sets and a brief set of practical and feasible recommendations are described for investigators to properly identify and qualify proteomic biomarkers, which could also be used as reporting requirements.
Journal ArticleDOI
Exosomes as biomarker treasure chests for prostate cancer.
TL;DR: This narrative review describes recent progress in exosome research, focusing on the potential role of exosomes as novel biomarkers for prostate cancer (PCa), to acquaint clinicians and researchers in the field of urology with the potential roles of exOSomes as biomarker treasure chests and with their clinical value.