T
Thomas F. Lüscher
Researcher at University of Zurich
Publications - 1613
Citations - 88517
Thomas F. Lüscher is an academic researcher from University of Zurich. The author has contributed to research in topics: Endothelium & Myocardial infarction. The author has an hindex of 134, co-authored 1560 publications receiving 79034 citations. Previous affiliations of Thomas F. Lüscher include University of Texas Southwestern Medical Center & Durham University.
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Is takotsubo syndrome a microvascular acute coronary syndrome? Towards of a new definition
TL;DR: The diagnosis of ACS relies on typical symptoms of ischaemia (chest pain) and typical ECG changes and/or elevated levels of cardiac troponins or other biomarkers of myocardial necrosis.
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Thrombin-induced endothelium-dependent inhibition and direct activation of platelet-vessel wall interaction. Role of prostacyclin, nitric oxide, and thromboxane A2.
Zhihong Yang,U. Arnet,Erwin Bauer,L. K. Von Segesser,R. Siebenmann,M. I. Turina,Thomas F. Lüscher +6 more
TL;DR: In arteries devoid of functional endothelial cells, as occurs in patients with coronary artery disease, a combined inhibition of thromboxane production and action provides a potent therapeutic tool to interfere with the thrombin-induced activation of platelet-vessel wall interaction.
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Endothelium-independent relaxation and hyperpolarization to C-type natriuretic peptide in porcine coronary arteries.
TL;DR: In conclusion, in contrast to bradykinin, CNP induces endothelium-independent and weaker relaxation and hyperpolarization of coronary artery vascular smooth muscle, suggesting that CNP is an unlikely mediator of endothelia-dependent hyperpolarsization of porcine coronary arteries.
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Cardiac CT and echocardiographic evaluation of peri‐device flow after percutaneous left atrial appendage closure using the AMPLATZER cardiac plug device
Milosz Jaguszewski,Costantina Manes,Gilbert Puippe,Sacha P. Salzberg,Maja Müller,Volkmar Falk,Thomas F. Lüscher,Andreas R. Luft,Hatem Alkadhi,Ulf Landmesser +9 more
TL;DR: The aim of the study was to examine frequency, size, and localization of peri‐device leaks after percutaneous left atrial appendage‐closure with the AMPLATZER‐Cardiac‐Plug by using a multimodal imaging approach, i.e. combined cardiac‐CT and TEE follow‐up.
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Pharmacological Mechanisms of Clinically Favorable Properties of a Selective β1‐Adrenoceptor Antagonist, Nebivolol
TL;DR: The antioxidant property of nebivolol can at least in part explain why treatment with this drug enhances eNOS activity and minimizes the reperfusion-induced myocardial injury and make nebivlol a promising therapeutic tool for the treatment of arterial hypertension and chronic heart failure.