T
Thomas F. Lüscher
Researcher at University of Zurich
Publications - 1613
Citations - 88517
Thomas F. Lüscher is an academic researcher from University of Zurich. The author has contributed to research in topics: Endothelium & Myocardial infarction. The author has an hindex of 134, co-authored 1560 publications receiving 79034 citations. Previous affiliations of Thomas F. Lüscher include University of Texas Southwestern Medical Center & Durham University.
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Journal ArticleDOI
Statin Prevents Tissue Factor Expression in Human Endothelial Cells Role of Rho/Rho-Kinase and Akt Pathways
TL;DR: Endothelial tissue factor induction by thrombin is regulated by Rho/Rho-kinase, Akt, and p38 MAP kinase, which provides new insights into the action of statins in acute coronary syndromes.
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Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial.
Inder S. Anand,John J.V. McMurray,Jay N. Cohn,Marvin A. Konstam,Thomas Notter,Kurt Quitzau,Frank Ruschitzka,Thomas F. Lüscher +7 more
TL;DR: Endothelin(A) blockade with darusentan did not improve cardiac remodelling or clinical symptoms or outcomes in patients with chronic heart failure receiving an angiotensin-converting-enzyme inhibitor, beta blocker, or aldosterone antagonist, and is unlikely to be useful as an add-on treatment in such patients.
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Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors
Xinmin S. Li,Slayman Obeid,Roland Klingenberg,Baris Gencer,François Mach,Lorenz Räber,Stephan Windecker,Nicolas Rodondi,David Nanchen,Olivier Muller,Melroy X. Miranda,Christian M. Matter,Yuping Wu,Lin Li,Zeneng Wang,Hassan S. Alamri,Hassan S. Alamri,Valentin Gogonea,Valentin Gogonea,Yoon-Mi Chung,W.H. Wilson Tang,W.H. Wilson Tang,Stanley L. Hazen,Stanley L. Hazen,Thomas F. Lüscher +24 more
TL;DR: Plasma TMAO levels among patients presenting with chest pain predict both near- and long-term risks of incident cardiovascular events, and may thus provide clinical utility in risk stratification among subjects presenting with suspected ACS.
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Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66shc Gene
Marcello Rota,Nicole LeCapitaine,Toru Hosoda,Alessandro Boni,Antonella De Angelis,Maria Elena Padin-Iruegas,Grazia Esposito,Serena Vitale,Konrad Urbanek,Claudia Casarsa,Marco Giorgio,Thomas F. Lüscher,Pier Giuseppe Pelicci,Piero Anversa,Annarosa Leri,Jan Kajstura +15 more
TL;DR: In a model of insulin-dependent diabetes mellitus, the generation of reactive oxygen species (ROS) leads to telomeric shortening, expression of the senescent associated proteins p53 and p16INK4a, and apoptosis of CPCs, impairing the growth reserve of the heart, suggesting that intact CPCs can effectively counteract the impact of uncontrolled diabetes on the heart.
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Angiotensin II Increases Tissue Endothelin and Induces Vascular Hypertrophy
Pierre Moreau,Livius V. d’Uscio,Sidney G. Shaw,Hiroyuki Takase,Matthias Barton,Thomas F. Lüscher +5 more
TL;DR: In this paper, the endogenous effect of endothelin-1 on angiotensin II-induced hypertrophy of small arteries in vivo has been investigated and it was shown that endothein-1 increased media thickness, media/lumen ratio, and cross-sectional area of basilar and small mesenteric arteries.