Thomas F. Lüscher

TL;DR: It is demonstrated that CTGF can also act as a growth inhibitor in human aortic smooth muscle cells at least in part by inducing apoptosis, which may be important for the formation and composition of lesions and plaque stability in atherosclerosis.

TL;DR: Together with the local expression patterns of chemokines and cytokines, the increase of TLR-4 reflects a concerted activation of this inflammatory pathway at the site of coronary occlusion in ACS.

TL;DR: Elevated serum testosterone levels in males and decreased estradiol levels in females are independently associated with MACE in ARVC/D, and directly influence disease pathology, determining the levels of sex hormones may be useful for risk stratification and may open a new window for preventive interventions.

TL;DR: It is suggested that long-term treatment with Ang II modulates endothelin-1 protein expression in the rat aorta, and both antihypertensive drugs lowered blood pressure and normalized endothelial function, but only losartan prevented the increase in tissue endothelins-1 content.

TL;DR: The European Expert Group pointed out the major unmet need of standardization of measurements, trial design and procedural performance, and the need for high-quality, collaborative research and openness to new methods for recruitment, patient selection, and assessment of outcomes will be able to establish incontrovertibly whether device therapies for hypertension are effective.