T
Timo Itzel
Researcher at Heidelberg University
Publications - 36
Citations - 945
Timo Itzel is an academic researcher from Heidelberg University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 10, co-authored 25 publications receiving 639 citations. Previous affiliations of Timo Itzel include University of Mainz & National Institutes of Health.
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Journal ArticleDOI
DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery
M Ahrens,Ole Ammerpohl,Witigo von Schönfels,Julia Kolarova,Susanne Bens,Timo Itzel,Andreas Teufel,A Herrmann,Mario Brosch,Holger Hinrichsen,Wiebke Erhart,Jan Hendrik Egberts,Bence Sipos,Stefan Schreiber,Robert Häsler,Felix Stickel,Thomas Becker,Michael Krawczak,Christoph Röcken,Reiner Siebert,Clemens Schafmayer,Jochen Hampe +21 more
TL;DR: Liver samples from morbidly obese patients with all stages of NAFLD and controls were analyzed by array-based DNA methylation and mRNA expression profiling, providing an example of treatment-induced epigenetic organ remodeling in humans.
Journal ArticleDOI
Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues From Patients.
Andreas Teufel,Timo Itzel,Wiebke Erhart,Mario Brosch,X.-Y. Wang,Yong Ook Kim,Witigo von Schönfels,A Herrmann,Stefan Brückner,Felix Stickel,Jean-François Dufour,Triantafyllos Chavakis,Claus Hellerbrand,Rainer Spang,Thorsten Maass,Thomas Becker,Stefan Schreiber,Clemens Schafmayer,Detlef Schuppan,Jochen Hampe +19 more
TL;DR: On a pathway level, gene expression patterns in livers of mice on the high-fat diet were associated more closely with human fatty liver disease than other models.
Journal ArticleDOI
TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice.
F Wandrer,Stephanie Liebig,Silke Marhenke,Arndt Vogel,Katharina John,Michael P. Manns,Andreas Teufel,Timo Itzel,Thomas Longerich,Olaf Maier,Roman Fischer,Roland E. Kontermann,Klaus Pfizenmaier,Klaus Schulze-Osthoff,Klaus Schulze-Osthoff,Heike Bantel +15 more
TL;DR: The therapeutic effects of a novel antibody, which selectively inhibits TNFR1 while retaining protective TNFR2 signaling in a high-fat diet mouse model of NAFLD, suggest selectiveTNFR1 inhibition as a promising approach forNAFLD treatment.
Journal ArticleDOI
Translating bioinformatics in oncology: guilt-by-profiling analysis and identification of KIF18B and CDCA3 as novel driver genes in carcinogenesis.
Timo Itzel,Peter Scholz,Thorsten Maass,Markus Krupp,Jens U. Marquardt,Susanne Strand,D Becker,Frank Staib,Harald Binder,Stephanie Roessler,Xin Wei Wang,Snorri S. Thorgeirsson,Martina Müller,PR Galle,Andreas Teufel +14 more
TL;DR: The efficacy of large-scale guilt-by-profiling/association strategies in oncology is proved as well as the strong prognostic importance of downstream predictors for HCC and many other tumors indicates the clinical relevance of the findings.
Journal ArticleDOI
Prognostic Cancer Gene Expression Signatures: Current Status and Challenges.
Yuquan Qian,Jimmy Daza,Timo Itzel,Johannes Betge,Johannes Betge,Tianzuo Zhan,Frederik Marmé,Andreas Teufel +7 more
TL;DR: In this article, the current status, and present and future challenges of prognostic gene signatures in three relevant cancer entities: breast cancer, colorectal cancer, and hepatocellular carcinoma.