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Wataru Yano
Researcher at University of Tokyo
Publications - 9
Citations - 2829
Wataru Yano is an academic researcher from University of Tokyo. The author has contributed to research in topics: Adiponectin & Insulin resistance. The author has an hindex of 7, co-authored 8 publications receiving 2687 citations.
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Journal ArticleDOI
Disruption of adiponectin causes insulin resistance and neointimal formation.
Naoto Kubota,Yasuo Terauchi,Toshimasa Yamauchi,Tetsuya Kubota,Masao Moroi,Junji Matsui,Kazuhiro Eto,Tokuyuki Yamashita,Junji Kamon,Hidemi Satoh,Wataru Yano,Philippe Froguel,Ryozo Nagai,Satoshi Kimura,Takashi Kadowaki,Tetsuo Noda,Tetsuo Noda +16 more
TL;DR: This study provides the first direct evidence that adiponectin plays a protective role against insulin resistance and atherosclerosis in vivo.
Journal ArticleDOI
Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake
Naoto Kubota,Wataru Yano,Tetsuya Kubota,Tetsuya Kubota,Toshimasa Yamauchi,Shinsuke Itoh,Hiroki Kumagai,Hideki Kozono,Iseki Takamoto,Shiki Okamoto,Tetsuya Shiuchi,Ryo Suzuki,Hidemi Satoh,Atsushi Tsuchida,Masao Moroi,Kaoru Sugi,Tetsuo Noda,Tetsuo Noda,Hiroyuki Ebinuma,Yoichi Ueta,Tatsuya Kondo,Eiichi Araki,Osamu Ezaki,Ryozo Nagai,Kazuyuki Tobe,Yasuo Terauchi,Kohjiro Ueki,Yasuhiko Minokoshi,Takashi Kadowaki +28 more
TL;DR: It is shown that adiponectin stimulates food intake and decreases energy expenditure during fasting through its effects in the central nervous system via its receptor AdipoR1 to stimulate food intake.
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Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways
Naoto Kubota,Yasuo Terauchi,Tetsuya Kubota,Hiroki Kumagai,Shinsuke Itoh,Hidemi Satoh,Wataru Yano,Hitomi Ogata,Kumpei Tokuyama,Iseki Takamoto,Tomoka Mineyama,Michiro Ishikawa,Masao Moroi,Kaoru Sugi,Toshimasa Yamauchi,Kohjiro Ueki,Kazuyuki Tobe,Tetsuo Noda,Tetsuo Noda,Ryozo Nagai,Takashi Kadowaki +20 more
TL;DR: In this article, pioglitazone-induced amelioration of insulin resistance and diabetes in ob/ob mice was attributed to decreased glucose production and increased AMP-activated protein kinase in the liver but not to increased glucose uptake in skeletal muscle.
Journal ArticleDOI
Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
Naoto Kubota,Yasuo Terauchi,Kazuyuki Tobe,Wataru Yano,Ryo Suzuki,Kohjiro Ueki,Iseki Takamoto,Hidemi Satoh,Toshiyuki Maki,Tetsuya Kubota,Masao Moroi,Miki Okada-Iwabu,Osamu Ezaki,Ryozo Nagai,Yoichi Ueta,Takashi Kadowaki,Tetsuo Noda +16 more
TL;DR: It is concluded that, in beta cells and the hypothalamus, Irs2 is crucially involved in the regulation of beta cell mass and leptin sensitivity.
Journal ArticleDOI
Molecular mechanism of moderate insulin resistance in adiponectin-knockout mice.
Wataru Yano,Naoto Kubota,Shinsuke Itoh,Tetsuya Kubota,Tetsuya Kubota,Motoharu Awazawa,Masao Moroi,Kaoru Sugi,Iseki Takamoto,Hitomi Ogata,Kumpei Tokuyama,Tetsuo Noda,Yasuo Terauchi,Kohjiro Ueki,Takashi Kadowaki +14 more
TL;DR: Impaired insulin signaling in the liver to cause hepatic insulin resistance was shown in adipo(-/-) mice, however, no increase in the triglyceride content was observed in either the liver or the skeletal muscle, presumably on account of the increased leptin sensitivity.