U
Ulrike Holzgrabe
Researcher at University of Würzburg
Publications - 591
Citations - 11158
Ulrike Holzgrabe is an academic researcher from University of Würzburg. The author has contributed to research in topics: Allosteric regulation & Capillary electrophoresis. The author has an hindex of 45, co-authored 566 publications receiving 9806 citations. Previous affiliations of Ulrike Holzgrabe include Jagiellonian University & University of Illinois at Chicago.
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Structure-activity relationships in a series of bisquaternary bisphthalimidine derivatives modulating the muscarinic M(2)-receptor allosterically.
H.M.Botero Cid,Christian Tränkle,Knut Baumann,Rainer Pick,E Mies-Klomfass,E Kostenis,Klaus Mohr,Ulrike Holzgrabe +7 more
TL;DR: The analysis of the quantitative SAR indicated that a high allosteric potency is related to a certain amount of rigidity as well as polarizibility and the ability to form hydrophobic interactions.
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Design, Synthesis, and Action of Oxotremorine-Related Hybrid-Type Allosteric Modulators of Muscarinic Acetylcholine Receptors
Teresa Disingrini,Mathias Muth,Clelia Dallanoce,Elisabetta Barocelli,Simona Bertoni,Kerstin Kellershohn,Klaus Mohr,Marco De Amici,Ulrike Holzgrabe +8 more
TL;DR: A novel series of muscarinic receptor ligands of the hexamethonio-type was prepared which contained the phthalimidopropane or 1,8-naphthalimido-2,2-dimethylpropane moiety typical for subtype selective allosteric antagonists and, on the other, the acetylenic fragment typical for the nonselective orthosteric mus carinic agonists oxotremorine, oxotremeorine-M
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Transformation of acidic poorly water soluble drugs into ionic liquids
TL;DR: The creation of TBP ionic liquids or solid salts from APIs is a valuable concept addressing dissolution and solubility challenges of poorly water soluble acidic compounds and is suggested that tailor-made counterions may substantially expand the formulation scientist's armamentarium to meet challenges of well water soluble drugs.
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Analysis of the glucosinolate pattern of Arabidopsis thaliana seeds by capillary zone electrophoresis coupled to electrospray ionization-mass spectrometry
Gerhard Bringmann,Inga Kajahn,Christian Neusüß,Matthias Pelzing,Stefanie Laug,Matthias Unger,Ulrike Holzgrabe +6 more
TL;DR: The sensitivity together with mass accuracy and true isotopic pattern of the TOF‐MS allowed identification of a broad series of glucosinolates in Arabidopsis thaliana seeds.
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Allosteric modulators of ligand binding to muscarinic acetylcholine receptors
Ulrike Holzgrabe,Klaus Mohr +1 more
TL;DR: Allosterically acting drugs represent a novel approach for affecting muscarinic receptors and may act as subtype-selective enhancers of acetylcholine binding, to improve cognition or to promote antinociception, for example.