U
Ulrike Holzgrabe
Researcher at University of Würzburg
Publications - 591
Citations - 11158
Ulrike Holzgrabe is an academic researcher from University of Würzburg. The author has contributed to research in topics: Allosteric regulation & Capillary electrophoresis. The author has an hindex of 45, co-authored 566 publications receiving 9806 citations. Previous affiliations of Ulrike Holzgrabe include Jagiellonian University & University of Illinois at Chicago.
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A new synthetic route to compounds of the AFDX-type with affinity to muscarinic M2-receptor
Ulrike Holzgrabe,Eberhard Heller +1 more
TL;DR: In this paper, the piperidine ring, the benzodiazepine system, the phthalimide moiety and the chains connecting the ring systems were synthesized in a microwave assisted route.
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A New Molecular Mechanism To Engineer Protean Agonism at a G Protein-Coupled Receptor.
Anna De Min,Carlo Matera,Andreas Bock,Janine Holze,Jessica Kloeckner,Mathias Muth,Christian Traenkle,Marco De Amici,Terry P. Kenakin,Ulrike Holzgrabe,Clelia Dallanoce,Evi Kostenis,Klaus Mohr,Ramona Schrage +13 more
TL;DR: This study demonstrates that modulation of the ionic strength in a defined experimental set-up allows for analysis of G protein–coupled receptor activation in the absence and presence of a specific amount of spontaneous receptor activity, and posit that dynamic ligand binding may be the mechanism underlying protean agonism of dualsteric ligands.
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Quinolone Amides as Antitrypanosomal Lead Compounds with In Vivo Activity.
Georg Hiltensperger,Nina Hecht,Marcel Kaiser,Jens-Christoph Rybak,Alexander Hoerst,Nicole Dannenbauer,Klaus Müller-Buschbaum,Heike Bruhn,Harald L. Esch,Leane Lehmann,Lorenz Meinel,Ulrike Holzgrabe +11 more
TL;DR: Spray-dried GHQ168 demonstrated exciting antitrypanosomal efficacy and was statistically significant mean survival times exceeding 32 days (end of the observation period) versus 7 days for theGHQ168 and control treatments, respectively.
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Quantitation of talinolol and other β-blockers by capillary electrophoresis for in vitro drug absorption studies
TL;DR: A capillary zone electrophoresis method is described for the enantioseparation of talinolol using heptakis(2,3‐diacetyl‐6‐sulfo)‐ β‐cyclodextrin (HDAS‐β‐CD) as a chiral selector and was found to be suitable in determination of tal inolol enantiomers in highly diluted samples obtained from in vitro experiments.
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Profiling a gut microbiota-generated catechin metabolite's fate in human blood cells using a metabolomic approach
TL;DR: The present study provides the first evidence that multiple and structurally heterogeneous polyphenol metabolites can be generated in human blood cells and their contribution to the previously determined anti-inflammatory effects of M1 now need to be elucidated.