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Ulrike Holzgrabe
Researcher at University of Würzburg
Publications - 591
Citations - 11158
Ulrike Holzgrabe is an academic researcher from University of Würzburg. The author has contributed to research in topics: Allosteric regulation & Capillary electrophoresis. The author has an hindex of 45, co-authored 566 publications receiving 9806 citations. Previous affiliations of Ulrike Holzgrabe include Jagiellonian University & University of Illinois at Chicago.
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The contamination of valsartan and other sartans, Part 2: Untargeted screening reveals contamination with amides additionally to known nitrosamine impurities.
Oliver Scherf-Clavel,Martina Kinzig,Axel Besa,André Schreiber,Clemens Bidmon,Mona Abdel-Tawab,Jonas Wohlfart,Fritz Sörgel,Ulrike Holzgrabe +8 more
TL;DR: Generic untargeted approach on sartan containing drug products revealed two new impurities in various sartans drug products: valeramide and N,N-dimethylvaleramide.
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A systematic review of the stability of finished pharmaceutical products and drug substances beyond their labeled expiry dates.
TL;DR: It seems to be reasonable for a large portion of drugs to extend the expiry dates far beyond five years and to discuss the actual shelf‐life with regard to the respective dosage form and the affiliation of the drug class.
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In search of novel agents for therapy of tropical diseases and human immunodeficiency virus.
Tim Goebel,Daniela Ulmer,Holger Projahn,Jessica Kloeckner,Eberhard Heller,Melanie Glaser,Alicia Ponte-Sucre,Sabine Specht,Salem Ramadan Sarite,Achim Hoerauf,Annette Kaiser,Ilona Hauber,Joachim Hauber,Ulrike Holzgrabe +13 more
TL;DR: The targeting of the enzymes of the polyamine pathway may provide novel therapy options and inhibit the deoxyhypusine hydroxylase, which is an important step in the biosynthesis of the eukaryotic initiation factor 5A.
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Pentacyclic triterpenes from Cecropia telenitida with immunomodulatory activity on dendritic cells
Guillermo L. Montoya Peláez,Guillermo L. Montoya Peláez,Jelver Sierra,Fernando Alzate,Ulrike Holzgrabe,José R. Ramírez-Pineda +5 more
TL;DR: Results show that all pentacyclic triterpenes might contribute to the anti-inflammatory activities of C. telenitida, and yarumic acid as well as the four known pentacyClic tritepenes can be exploited as potential immunomodulatory/anti-inflammatory agents.
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Determination of protein binding of gyrase inhibitors by means of continuous ultrafiltration.
TL;DR: In this study, 18 gyrase inhibitors in clinical practice, characterized by a lower extent of protein binding, were subjected to the titration procedure of the continuous ultrafiltration using bovine and human serum albumin (BSA, HSA), and human plasma.