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Ulrike Holzgrabe
Researcher at University of Würzburg
Publications - 591
Citations - 11158
Ulrike Holzgrabe is an academic researcher from University of Würzburg. The author has contributed to research in topics: Allosteric regulation & Capillary electrophoresis. The author has an hindex of 45, co-authored 566 publications receiving 9806 citations. Previous affiliations of Ulrike Holzgrabe include Jagiellonian University & University of Illinois at Chicago.
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Determination of clotrimazole in mice plasma by capillary electrophoresis.
TL;DR: It is shown that with the described capillary zone electrophoresis (CZE) method it is possible to handle small sample volumes of 60 microl, to detect clotrimazole concentrations of 0.3 microg ml(-1) (limit of detection), and to quantify clotrimzole down to concentrations of0.5 microgml(-1), the limit of quantification.
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One-Pot Ugi/Aza-Michael Synthesis of Highly Substituted 2,5-Diketopiperazines with Anti-Proliferative Properties
TL;DR: The obtained diketopiperazines show anti-proliferative effects on activated T cells and represent therefore potential candidates for targeting unwanted T cell-mediated immune responses.
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Impurity profiling of L-methionine by HPLC on a mixed mode column.
TL;DR: A sensitive HPLC method for the determination of impurities in L-methionine was developed and validated using a SIELC(®) Primesep 100 column and found to be precise and accurate.
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Drug Discovery: A Modern Decathlon
TL;DR: This work aims to highlight, from the point of view of German academic pharmaceutical sciences, the contexts in which contributions from academia are particularly reasonable, and four related articles were published in 2012.
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Quantitative structure-property relationship modeling of polar analytes lacking UV chromophores to charged aerosol detector response.
TL;DR: A quantitative structure-property relationship model was built in order to link molecular descriptors and chromatographic parameters as inputs towards CAD responsiveness, showing the possibility of using evaporative chaotropic reagents in CAD response improvement when dealing with highly polar substances that act as kosmotropes.