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Ulrike Holzgrabe
Researcher at University of Würzburg
Publications - 591
Citations - 11158
Ulrike Holzgrabe is an academic researcher from University of Würzburg. The author has contributed to research in topics: Allosteric regulation & Capillary electrophoresis. The author has an hindex of 45, co-authored 566 publications receiving 9806 citations. Previous affiliations of Ulrike Holzgrabe include Jagiellonian University & University of Illinois at Chicago.
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Journal ArticleDOI
Characterization of polydisperse macrogols and macrogol-based excipients via HPLC and charged aerosol detection.
TL;DR: An alternative and supplemental method to characterize macrogol‐based emulsifiers was developed, using a HPLC‐system coupled to a charged aerosol detector (CAD), suitable to separate polymer macrogols from PEG 300 to PEG 3000.
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A Fast and Efficient Track to Allosteric Modulators of Muscarinic Receptors: Microwave-Assisted Syntheses
TL;DR: By using microwave irradiation bisammonium-and bispyridinium-type allosteric modulators of muscarinic receptors can be obtained fast and efficiently.
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Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major
Jua Iwasaki,Don Lorimer,Mirella Vivoli-Vega,Emily A Kibble,Christopher S. Peacock,Jan Abendroth,Stephen J. Mayclin,David M. Dranow,Phillip G. Pierce,David A. Fox,Mary Beth Lewis,Nicole M. Bzdyl,Sofie S. Kristensen,Timothy J. J. Inglis,Charlene M. Kahler,Charles S. Bond,A. Hasenkopf,Florian Seufert,Jens Schmitz,Laura E. Marshall,Andrew E. Scott,Isobel H. Norville,Peter J. Myler,Ulrike Holzgrabe,Nicholas J. Harmer,Mitali Sarkar-Tyson +25 more
TL;DR: Co-crystallography experiments with recombinant B. pseudomallei Mip protein and Mip inhibitors, biochemical analysis and computational modelling were used to predict the efficacy of lead compounds for broad-spectrum activity against other pathogens, indicating that Mip is a novel antivirulence target that can be inhibited using small-molecule compounds that prove to be promising broad- spectrum drug candidates in vitro.
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Variation of the Oxime Function of Bispyridinium-Type Allosteric Modulators of M2-Cholinoceptors.
TL;DR: The conclusion has been drawn that the between distance the terminal ring-system and the positive charge is pivotal for the interaction of the allosteric modulators with the receptor protein.
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Glycerolipid Composition and Advanced Physicochemical Considerations of Sacha Inchi Oil toward Cosmetic Products Formulation
Diana Penagos-Calvete,Valeria Duque,Claudia Marimon,Diana M. Parra,Sandra K. Restrepo-Arango,Oliver Scherf-Clavel,Ulrike Holzgrabe,Guillermo Montoya,Constain H. Salamanca +8 more
TL;DR: In this article, a detailed description of the lipid composition using high-resolution tandem mass spectrometry and thorough physicochemical characterization to find the value of the required hydrophilic-lipophilic balance (HLB) was provided.