U
Ulrike Holzgrabe
Researcher at University of Würzburg
Publications - 591
Citations - 11158
Ulrike Holzgrabe is an academic researcher from University of Würzburg. The author has contributed to research in topics: Allosteric regulation & Capillary electrophoresis. The author has an hindex of 45, co-authored 566 publications receiving 9806 citations. Previous affiliations of Ulrike Holzgrabe include Jagiellonian University & University of Illinois at Chicago.
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Journal ArticleDOI
Population Pharmacokinetic Comparison and Pharmacodynamic Breakpoints of Ceftazidime in Cystic Fibrosis Patients and Healthy Volunteers
Jürgen B. Bulitta,Cornelia B. Landersdorfer,S. Hüttner,George L. Drusano,Martina Kinzig,Ulrike Holzgrabe,U Stephan,Fritz Sörgel +7 more
TL;DR: The population PK and PK/pharmacodynamic breakpoints of ceftazidime in cystic fibrosis patients and healthy volunteers were assessed by Monte Carlo simulations and linear and allometric body size models were considered to scale clearance and volume of distribution.
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Design, synthesis and evaluation of novel 2-(aminoalkyl)-isoindoline-1,3-dione derivatives as dual-binding site acetylcholinesterase inhibitors
Michalina Ignasik,Marek Bajda,Natalia Guzior,Michaela Prinz,Ulrike Holzgrabe,Barbara Malawska +5 more
TL;DR: The most promising selective AChE inhibitors are compounds 10 and 11, with 6–7 methylene chains, which also inhibit Aβ fibril formation, which support the outcome of docking studies which tested compounds targeting both the catalytic active site (CAS) and the peripheral anionic site (PAS) of A ChE.
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Quantitative NMR spectroscopy of biologically active substances and excipients
TL;DR: This review elaborate on the application of qNMR to three important classes of biological substances, namely polysaccharides, amino acids, and lipids, and demonstrate the benefits of this modern tool in contrast to traditional techniques.
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Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with beta-amyloid, acetylcholine, and butyrylcholine esterases.
Vildan Alptüzün,Michaela Prinz,Verena Hörr,Josef Scheiber,Krzysztof Radacki,Adyary Fallarero,Pia Vuorela,Bernd Engels,Holger Braunschweig,Ercin Erciyas,Ulrike Holzgrabe +10 more
TL;DR: New bisphenyl-substituted pyridinylidene hydrazones 5 are appropriate to cross the blood-brain barrier due to their pK(a) values and lipophilicity, and to inhibit both the AChE and BuChE.
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Control of impurities in L-aspartic acid and L-alanine by high-performance liquid chromatography coupled with a corona charged aerosol detector.
TL;DR: The reversed phase ion-pair high-performance liquid chromatography method using charged aerosol detection was developed and fully validated for the pharmaceutical quality control of L-aspartic acid (Asp) and with a slight modification, the method also allows the evaluation of related substances in L-alanine (Ala).